U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CASC18 cancer susceptibility 18 [ Homo sapiens (human) ]

Gene ID: 101929110, updated on 10-Oct-2023

Summary

Go to the top of the page Help
Official Symbol
CASC18provided by HGNC
Official Full Name
cancer susceptibility 18provided by HGNC
Primary source
HGNC:HGNC:49463
See related
Ensembl:ENSG00000257859 AllianceGenome:HGNC:49463
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Low expression observed in reference dataset See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
12q23.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (105704203..105744063)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (105667013..105706864)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (106097981..106137841)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369958 Neighboring gene Sharpr-MPRA regulatory region 9585 Neighboring gene uncharacterized LOC124903006 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:105955477-105956256 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:106022357-106023010 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:106091383-106092582 Neighboring gene uncharacterized LOC105369959 Neighboring gene uncharacterized LOC107984435 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:106133756-106134367 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:106134368-106134978 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:106138325-106138868 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:106170114-106170679 Neighboring gene uncharacterized LOC105369960 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6943 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6944 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:106254933-106255434 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:106289604-106290350 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:106290351-106291097 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:106291098-106291844 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:106328523-106329722 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:106348645-106349844 Neighboring gene ST13, Hsp70 interacting protein pseudogene 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Introduction of novel splice variants for CASC18 gene and its relation to the neural differentiation. Mehravar M, et al. Gene, 2017 Mar 1. PMID 27956168
  2. Association of CASC18/miR-20a-3p/TGFB2 ceRNA axis with occult lymph node metastasis in tongue squamous cell carcinoma. Zhou B, et al. Mol Med, 2021 Aug 6. PMID 34362313, Free PMC Article
  3. APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study. Ramanan VK, et al. Mol Psychiatry, 2014 Mar. PMID 23419831, Free PMC Article
  4. RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation. Wu SF, et al. Proc Natl Acad Sci U S A, 2020 Jun 23. PMID 32513696, Free PMC Article
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Association of CASC18/miR-20a-3p/TGFB2 ceRNA axis with occult lymph node metastasis in tongue squamous cell carcinoma.
    Title: Association of CASC18/miR-20a-3p/TGFB2 ceRNA axis with occult lymph node metastasis in tongue squamous cell carcinoma.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Other Names

  • cancer susceptibility 18 (non-protein coding)
  • cancer susceptibility candidate 18 (non-protein coding)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_110108.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate exons compared to variant 1.
    Source sequence(s)
    AB849958
    Related
    ENST00000548557.1

  2. NR_110109.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AB849958, AB849961

  3. NR_110110.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate first exon and lacks two alternate exons compared to variant 1.
    Source sequence(s)
    AB849963

  4. NR_110111.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate first exon and lacks three alternate exons compared to variant 1.
    Source sequence(s)
    AC079851, AC084356

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    105704203..105744063
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    105667013..105706864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases