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EPIST esophagus epithelial intergenic associated transcript [ Homo sapiens (human) ]

Gene ID: 101927953, updated on 10-Oct-2023

Summary

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Official Symbol
EPISTprovided by HGNC
Official Full Name
esophagus epithelial intergenic associated transcriptprovided by HGNC
Primary source
HGNC:HGNC:49679
See related
Ensembl:ENSG00000249082 AllianceGenome:HGNC:49679
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C5orf66-AS1
Expression
Biased expression in salivary gland (RPKM 1.5), esophagus (RPKM 0.8) and 7 other tissues See more
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Genomic context

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Location:
5q31.1
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (135038831..135040047, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (135565846..135567062, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (134374521..134375737, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr5:134312555-134313067 Neighboring gene cation channel sperm associated 3 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:134325851-134326415 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:134360625-134361824 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134362037-134362626 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:134362736-134363421 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134364793-134365477 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:134367424-134367631 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:134368802-134369434 Neighboring gene PITX1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134384389-134384989 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134386169-134386753 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23167 Neighboring gene paired like homeodomain 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134401324-134402015 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134403398-134404087 Neighboring gene uncharacterized LOC124901072 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134470142-134471024 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134471025-134471907 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:134509397-134509555 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134549501-134550001 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134563187-134563687 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:134565392-134565953 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23168 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23169 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:134574510-134575316 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:134582317-134583516 Neighboring gene long intergenic non-protein coding RNA 2900

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Aberrant methylation-mediated silencing of lncRNA CTC-276P9.1 is associated with malignant progression of esophageal squamous cell carcinoma. Guo W, et al. Clin Exp Metastasis, 2018 Feb. PMID 29524086
  2. Transcriptome profiling of esophageal squamous cell carcinoma reveals a long noncoding RNA acting as a tumor suppressor. Wei G, et al. Oncotarget, 2015 Jul 10. PMID 26158411, Free PMC Article
  3. Long non-coding RNA C5orf66-AS1 promotes cell proliferation in cervical cancer by targeting miR-637/RING1 axis. Rui X, et al. Cell Death Dis, 2018 Dec 5. PMID 30518760, Free PMC Article
  4. Long non-coding RNA C5orf66-AS1 is downregulated in pituitary null cell adenomas and is associated with their invasiveness. Yu G, et al. Oncol Rep, 2017 Aug. PMID 28656268, Free PMC Article
  5. Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes. Choy KW, et al. Physiol Genomics, 2006 Mar 13. PMID 16368877

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA C5orf66-AS1, as a competitive endogenous RNA, regulated the effect of RING1 on the proliferation, apoptosis and cell cycle of cervical cancer cells through adsorbing miR-637.
    Title: Long non-coding RNA C5orf66-AS1 promotes cell proliferation in cervical cancer by targeting miR-637/RING1 axis.
  2. Low C5orf66-AS1 expression is associated with pituitary null cell adenomas.
    Title: Long non-coding RNA C5orf66-AS1 is downregulated in pituitary null cell adenomas and is associated with their invasiveness.
  3. our analysis of the Esophageal Squamous Cell Carcinoma transcriptome identified the potential tumor suppressing lncRNA Epist
    Title: Transcriptome profiling of esophageal squamous cell carcinoma reveals a long noncoding RNA acting as a tumor suppressor.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Other Names

  • C5orf66 antisense RNA 1
  • esophagus epithelial intergenic specific transcript

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_105049.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AC008406, BE785577, BY798674
    Related
    ENST00000507035.2

  2. NR_105050.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' exon, resulting in a shorter transcript, compared to variant 1.
    Source sequence(s)
    AC008406

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    135038831..135040047 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    135565846..135567062 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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