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CDK6-AS1 CDK6 antisense RNA 1 [ Homo sapiens (human) ]

Gene ID: 101927497, updated on 10-Oct-2023

Summary

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Official Symbol
CDK6-AS1provided by HGNC
Official Full Name
CDK6 antisense RNA 1provided by HGNC
Primary source
HGNC:HGNC:40141
See related
Ensembl:ENSG00000237819 AllianceGenome:HGNC:40141
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BALR-2
Expression
Biased expression in bone marrow (RPKM 1.0), testis (RPKM 0.3) and 11 other tissues See more
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Genomic context

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Location:
7q21.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (92836483..92917187)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (94078472..94159167)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (92465797..92546501)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268009 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26267 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26268 Neighboring gene cyclin dependent kinase 6 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:92324714-92325913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26269 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26270 Neighboring gene NANOG hESC enhancer GRCh37_chr7:92353193-92353749 Neighboring gene RNA, U6 small nuclear 10, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26272 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:92393426-92394053 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:92397855-92398394 Neighboring gene MPRA-validated peak6637 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26273 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:92438696-92439895 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:92462135-92462635 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18375 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26276 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18376 Neighboring gene CRISPRi-validated cis-regulatory element chr7.3172 Neighboring gene RNA, 7SL, cytoplasmic 7, pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:92651586-92652785 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:92657799-92658383 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:92668331-92668846 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26277 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:92669879-92670393 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr7:92673175-92673906 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26278 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:92737283-92738482 Neighboring gene sterile alpha motif domain containing 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. [The effects of long non-coding RNA AC002454.1 on the biological behaviour of NB4 leukemia cells]. Cao L, et al. Zhonghua Xue Ye Xue Za Zhi, 2019 Oct 14. PMID 31775489, Free PMC Article
  2. Functional role of lncRNA LOC101927497 in N-methyl-N'-nitro-N-nitrosoguanidine-induced malignantly transformed human gastric epithelial cells. Luo Y, et al. Life Sci, 2018 Jan 15. PMID 29223541
  3. LncRNA Expression Discriminates Karyotype and Predicts Survival in B-Lymphoblastic Leukemia. Fernando TR, et al. Mol Cancer Res, 2015 May. PMID 25681502, Free PMC Article
  4. AC002454.1 and CDK6 synergistically promote endometrial cell migration and invasion in endometriosis. Liu J, et al. Reproduction, 2019 Jun. PMID 30884467
  5. Differential gene expression of BCL-2, ZEB2-AS1 and BALR-2 in prostate cancer and benign prostatic hyperplasia. Ahani M, et al. Andrologia, 2022 Apr. PMID 34866225

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Differential gene expression of BCL-2, ZEB2-AS1 and BALR-2 in prostate cancer and benign prostatic hyperplasia.
    Title: Differential gene expression of BCL-2, ZEB2-AS1 and BALR-2 in prostate cancer and benign prostatic hyperplasia.
  2. both AC002454.1 and CDK6 positively regulated the proliferation, migration and invasion ability of eutopic endometrial cells and could promote the transformation of cells from G0/G1 phase to S phase
    Title: AC002454.1 and CDK6 synergistically promote endometrial cell migration and invasion in endometriosis.
  3. AC002454.1 is in leukemia cells
    Title: [The effects of long non-coding RNA AC002454.1 on the biological behaviour of NB4 leukemia cells].
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Other Names

  • B-ALL associated long RNA-2

Clone Names

  • AC002454.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_110086.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    BG213706, BG256720, CB217567

  2. NR_110087.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two internal exons, compared to variant 1.
    Source sequence(s)
    BG213706, BM152701, CB217567
    Related
    ENST00000686356.1

  3. NR_110088.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks three internal exons, compared to variant 1.
    Source sequence(s)
    BG213706, CB217567
    Related
    ENST00000435695.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    92836483..92917187
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    94078472..94159167
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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