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Unc45a unc-45 myosin chaperone A [ Mus musculus (house mouse) ]

Gene ID: 101869, updated on 21-Apr-2024

Summary

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Official Symbol
Unc45aprovided by MGI
Official Full Name
unc-45 myosin chaperone Aprovided by MGI
Primary source
MGI:MGI:2142246
See related
Ensembl:ENSMUSG00000030533 AllianceGenome:MGI:2142246
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables Hsp90 protein binding activity. Acts upstream of or within chaperone-mediated protein folding. Predicted to be located in Golgi apparatus; cytosol; and nuclear speck. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and retina. Orthologous to human UNC45A (unc-45 myosin chaperone A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 26.2), colon adult (RPKM 23.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 D2; 7 45.65 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (79975040..79990748, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80325292..80341000, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2826 Neighboring gene vacuolar protein sorting 33B Neighboring gene STARR-positive B cell enhancer ABC_E2827 Neighboring gene RCC1 domain containing 1 Neighboring gene protein regulator of cytokinesis 1 Neighboring gene STARR-positive B cell enhancer ABC_E2828 Neighboring gene STARR-positive B cell enhancer ABC_E6566 Neighboring gene HD domain containing 3 Neighboring gene high mobility group box 2 pseudogene Neighboring gene mannosidase 2, alpha 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. UNC-45A Is Highly Expressed in the Proliferative Cells of the Mouse Genital Tract and in the Microtubule-Rich Areas of the Mouse Nervous System. Clemente V, et al. Cells, 2021 Jun 26. PMID 34206743, Free PMC Article
  2. A new type-II membrane protein in erythropoietic organs enhances erythropoiesis. Yanai N, et al. Leukemia, 1997 Apr. PMID 9209433
  3. The ATPase mechanism of myosin 15, the molecular motor mutated in DFNB3 human deafness. Jiang F, et al. J Biol Chem, 2021 Jan-Jun. PMID 33372036, Free PMC Article
  4. Unc45 activates Hsp90-dependent folding of the myosin motor domain. Liu L, et al. J Biol Chem, 2008 May 9. PMID 18326487, Free PMC Article
  5. Two mammalian UNC-45 isoforms are related to distinct cytoskeletal and muscle-specific functions. Price MG, et al. J Cell Sci, 2002 Nov 1. PMID 12356907

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UNC-45A Is Highly Expressed in the Proliferative Cells of the Mouse Genital Tract and in the Microtubule-Rich Areas of the Mouse Nervous System.
    Title: UNC-45A Is Highly Expressed in the Proliferative Cells of the Mouse Genital Tract and in the Microtubule-Rich Areas of the Mouse Nervous System.
  2. The ATPase mechanism of myosin 15, the molecular motor mutated in DFNB3 human deafness.
    Title: The ATPase mechanism of myosin 15, the molecular motor mutated in DFNB3 human deafness.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Hsp90 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Hsp90 protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in chaperone-mediated protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chaperone-mediated protein folding IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within muscle organ development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein unc-45 homolog A
Names
SMAP-1
UNC-45A
smooth muscle cell associated protein-1
stromal membrane-associated protein 1
unc-45 homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133952.2 → NP_598713.2  protein unc-45 homolog A

    See identical proteins and their annotated locations for NP_598713.2

    Status: VALIDATED

    Source sequence(s)
    AK166809, BB842393, CJ323134
    Consensus CDS
    CCDS21395.1
    UniProtKB/Swiss-Prot
    Q3TKV6, Q8BFT3, Q8C157, Q99KD5
    UniProtKB/TrEMBL
    A0A5K1VVS7
    Related
    ENSMUSP00000032748.9, ENSMUST00000032748.15
    Conserved Domains (3) summary
    TIGR00990
    Location:7 → 115
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:21 → 49
    TPR; TPR repeat [structural motif]
    pfam11701
    Location:361 → 505
    UNC45-central; Myosin-binding striated muscle assembly central

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    79975040..79990748 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250775.1 → XP_011249077.1  protein unc-45 homolog A isoform X2

    UniProtKB/TrEMBL
    A0A5K1VVS7
    Related
    ENSMUSP00000102991.3, ENSMUST00000107368.9
    Conserved Domains (3) summary
    TIGR00990
    Location:6 → 100
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:6 → 34
    TPR; TPR repeat [structural motif]
    pfam11701
    Location:346 → 490
    UNC45-central; Myosin-binding striated muscle assembly central

  2. XM_006540542.2 → XP_006540605.1  protein unc-45 homolog A isoform X3

    Conserved Domains (1) summary
    pfam11701
    Location:216 → 360
    UNC45-central; Myosin-binding striated muscle assembly central

  3. XM_011250774.1 → XP_011249076.1  protein unc-45 homolog A isoform X1

    See identical proteins and their annotated locations for XP_011249076.1

    UniProtKB/Swiss-Prot
    Q3TKV6, Q8BFT3, Q8C157, Q99KD5
    UniProtKB/TrEMBL
    A0A5K1VVS7
    Conserved Domains (3) summary
    TIGR00990
    Location:7 → 115
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:21 → 49
    TPR; TPR repeat [structural motif]
    pfam11701
    Location:361 → 505
    UNC45-central; Myosin-binding striated muscle assembly central

  4. XM_017321917.1 → XP_017177406.1  protein unc-45 homolog A isoform X3

    Conserved Domains (1) summary
    pfam11701
    Location:216 → 360
    UNC45-central; Myosin-binding striated muscle assembly central
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99KD5.2 GenPept UniProtKB/Swiss-Prot:Q99KD5

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