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Rrp8 ribosomal RNA processing 8 [ Mus musculus (house mouse) ]

Gene ID: 101867, updated on 11-Apr-2024

Summary

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Official Symbol
Rrp8provided by MGI
Official Full Name
ribosomal RNA processing 8provided by MGI
Primary source
MGI:MGI:1914251
See related
Ensembl:ENSMUSG00000030888 AllianceGenome:MGI:1914251
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NML; 1500003O22Rik; 2900001K19Rik
Summary
Predicted to enable methylated histone binding activity. Predicted to be involved in several processes, including cellular response to glucose starvation; intrinsic apoptotic signaling pathway by p53 class mediator; and regulation of gene expression. Predicted to act upstream of or within chromatin organization; methylation; and rRNA processing. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be part of chromatin silencing complex. Predicted to be active in nucleolus and rDNA heterochromatin. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human RRP8 (ribosomal RNA processing 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 12.5), bladder adult (RPKM 9.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rrp8 in Genome Data Viewer
Location:
7 E3; 7 55.97 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (105380937..105386592, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (105731730..105737385, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene translocase of inner mitochondrial membrane 10B Neighboring gene predicted gene, 22504 Neighboring gene dynein heavy chain domain 1 Neighboring gene mitochondrial ribosomal protein S36, pseudogene 2 Neighboring gene STARR-positive B cell enhancer mm9_chr7:112892770-112893071 Neighboring gene STARR-positive B cell enhancer mm9_chr7:112900636-112900937 Neighboring gene integrin linked kinase Neighboring gene TATA-box binding protein associated factor 10 Neighboring gene tripeptidyl peptidase I

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hepatic rRNA transcription regulates high-fat-diet-induced obesity. Oie S, et al. Cell Rep, 2014 May 8. PMID 24746822
  2. Nucleomethylin deficiency impairs embryonic erythropoiesis. Murakami S, et al. J Biochem, 2018 May 1. PMID 29244083
  3. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
  4. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to glucose starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in energy homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in rDNA heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rDNA heterochromatin formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within rRNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_negative_effect regulation of G1 to G0 transition ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by glucose IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by glucose ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of chromatin silencing complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromatin silencing complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of eNoSc complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of rDNA heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of rDNA heterochromatin ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ribosomal RNA-processing protein 8
Names
cerebral protein 1 homolog
nucleomethylin protein
ribosomal RNA processing 8, methyltransferase, homolog
NP_080173.1
NP_598712.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025897.2 → NP_080173.1  ribosomal RNA-processing protein 8 isoform 2

    See identical proteins and their annotated locations for NP_080173.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate exon in the 5' UTR and 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC121823, AK005138, AV460242
    Consensus CDS
    CCDS21658.1
    UniProtKB/Swiss-Prot
    Q3T9X9, Q3TDD7, Q3U3A5, Q8BHW3, Q9DB85
    UniProtKB/TrEMBL
    Q3U4B0
    Related
    ENSMUSP00000033179.7, ENSMUST00000033179.14
    Conserved Domains (1) summary
    pfam05148
    Location:243 → 457
    Methyltransf_8; Hypothetical methyltransferase

  2. NM_133951.1 → NP_598712.1  ribosomal RNA-processing protein 8 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC121823
    Consensus CDS
    CCDS57576.1
    UniProtKB/TrEMBL
    E9PVA2, Q3U4B0
    Related
    ENSMUSP00000095752.5, ENSMUST00000098148.6
    Conserved Domains (1) summary
    pfam05148
    Location:289 → 503
    Methyltransf_8; Hypothetical methyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    105380937..105386592 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_378204.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DB85.1 GenPept UniProtKB/Swiss-Prot:Q9DB85

Gene LinkOut

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