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Ints4 integrator complex subunit 4 [ Mus musculus (house mouse) ]

Gene ID: 101861, updated on 5-Mar-2024

Summary

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Official Symbol
Ints4provided by MGI
Official Full Name
integrator complex subunit 4provided by MGI
Primary source
MGI:MGI:1917164
See related
Ensembl:ENSMUSG00000025133 AllianceGenome:MGI:1917164
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610034N24Rik
Summary
Predicted to be involved in snRNA processing. Predicted to be located in nucleolus. Predicted to be part of integrator complex. Is expressed in axial musculature; medulla oblongata basal plate; olfactory cortex marginal layer; submandibular gland primordium; and telencephalon ventricular layer. Orthologous to human INTS4 (integrator complex subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 15.6), ovary adult (RPKM 14.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ints4 in Genome Data Viewer
Location:
7 E1; 7 53.52 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (97130158..97190605)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (97480951..97541398)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_19596 Neighboring gene predicted gene, 32945 Neighboring gene potassium channel tetramerisation domain containing 14 Neighboring gene STARR-positive B cell enhancer ABC_E4950 Neighboring gene predicted gene, 24412 Neighboring gene adipogenesis associated Mth938 domain containing Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta, pseudogene 1 Neighboring gene remodeling and spacing factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal. Gagliardi A, et al. EMBO J, 2013 Aug 14. PMID 23892456, Free PMC Article
  2. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  3. Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. St-Denis N, et al. Cell Rep, 2016 Nov 22. PMID 27880917
  4. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
  5. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in snRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snRNA processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrator complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
integrator complex subunit 4
Names
int4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358012.1 → NP_001344941.1  integrator complex subunit 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC149605
    Conserved Domains (2) summary
    sd00044
    Location:367 → 394
    HEAT; HEAT repeat [structural motif]
    cl26317
    Location:371 → 452
    Adaptin_N; Adaptin N terminal region

  2. NM_027256.2 → NP_081532.1  integrator complex subunit 4 isoform 1

    See identical proteins and their annotated locations for NP_081532.1

    Status: VALIDATED

    Source sequence(s)
    AC149605, AK011676, AW493223, CA450656, CF724981, CX218921, CX565861
    Consensus CDS
    CCDS21460.1
    UniProtKB/Swiss-Prot
    Q3TQQ4, Q8C2H1, Q8CIM8, Q91YV5, Q9CSY4
    Related
    ENSMUSP00000026126.9, ENSMUST00000026126.10
    Conserved Domains (2) summary
    COG1413
    Location:52 → 257
    HEAT; HEAT repeat [General function prediction only]
    sd00044
    Location:200 → 222
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    97130158..97190605
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030241963.1 → XP_030097823.1  integrator complex subunit 4 isoform X2

    Conserved Domains (2) summary
    sd00044
    Location:366 → 393
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:370 → 451
    Adaptin_N; Adaptin N terminal region

  2. XM_006507179.4 → XP_006507242.1  integrator complex subunit 4 isoform X1

    See identical proteins and their annotated locations for XP_006507242.1

    Conserved Domains (3) summary
    COG1413
    Location:51 → 256
    HEAT; HEAT repeat [General function prediction only]
    sd00044
    Location:199 → 221
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:379 → 460
    Adaptin_N; Adaptin N terminal region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CIM8.1 GenPept UniProtKB/Swiss-Prot:Q8CIM8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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