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Trim68 tripartite motif-containing 68 [ Mus musculus (house mouse) ]

Gene ID: 101700, updated on 5-Mar-2024

Summary

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Official Symbol
Trim68provided by MGI
Official Full Name
tripartite motif-containing 68provided by MGI
Primary source
MGI:MGI:2142077
See related
Ensembl:ENSMUSG00000073968 AllianceGenome:MGI:2142077
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SS-56; Rnf137; F730114J12Rik
Summary
Predicted to enable several functions, including androgen receptor binding activity; enzyme binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including positive regulation of NF-kappaB transcription factor activity; protein ubiquitination; and regulation of signal transduction. Predicted to be located in Golgi apparatus and nucleolus. Predicted to be active in cytosol and nucleoplasm. Is expressed in genitourinary system. Orthologous to human TRIM68 (tripartite motif containing 68). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 23.0), subcutaneous fat pad adult (RPKM 9.9) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Trim68 in Genome Data Viewer
Location:
7 E3; 7 54.8 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (102326786..102336536, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (102677579..102687335, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 51 subfamily H member 1 Neighboring gene olfactory receptor family 52 subfamily J member 2 Neighboring gene olfactory receptor family 51 subfamily D member 1 Neighboring gene olfactory receptor family 51 subfamily E member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TRIM proteins and cancer. Hatakeyama S. Nat Rev Cancer, 2011 Oct 7. PMID 21979307
  2. TRIM68 negatively regulates IFN-β production by degrading TRK fused gene, a novel driver of IFN-β downstream of anti-viral detection systems. Wynne C, et al. PLoS One, 2014. PMID 24999993, Free PMC Article
  3. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
  4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables histone acetyltransferase binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear androgen receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of androgen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of viral entry into host cell IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase TRIM68
Names
RING-type E3 ubiquitin transferase TRIM68
ring finger protein 137
tripartite motif-containing protein 68
NP_001294927.1
NP_932129.2
XP_006507229.1
XP_006507231.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001307998.2 → NP_001294927.1  E3 ubiquitin-protein ligase TRIM68 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC161431, AK089546, AK164544, BY014556
    Consensus CDS
    CCDS85365.1
    UniProtKB/TrEMBL
    A0A1B0GSL9
    Related
    ENSMUSP00000147991.2, ENSMUST00000210855.2
    Conserved Domains (2) summary
    cd00021
    Location:96 → 134
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    pfam15227
    Location:16 → 60
    zf-C3HC4_4; zinc finger of C3HC4-type, RING

  2. NM_198012.4 → NP_932129.2  E3 ubiquitin-protein ligase TRIM68 isoform 1

    See identical proteins and their annotated locations for NP_932129.2

    Status: VALIDATED

    Source sequence(s)
    AC161431, AK089546, AK164544, BY014556, CO424835
    Consensus CDS
    CCDS40052.1
    UniProtKB/Swiss-Prot
    Q8K243
    UniProtKB/TrEMBL
    G3X9I6
    Related
    ENSMUSP00000080813.6, ENSMUST00000082175.7
    Conserved Domains (3) summary
    cd00021
    Location:96 → 134
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    pfam15227
    Location:16 → 60
    zf-C3HC4_4; zinc finger of C3HC4-type, RING
    cd13733
    Location:304 → 479
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    102326786..102336536 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507168.3 → XP_006507231.1  E3 ubiquitin-protein ligase TRIM68 isoform X2

    Conserved Domains (3) summary
    cd16610
    Location:13 → 61
    RING-HC_TRIM68_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 68 (TRIM68) and similar proteins
    pfam02335
    Location:112 → 188
    Cytochrom_C552; Cytochrome c552
    cl00034
    Location:96 → 138
    Bbox_SF; B-box-type zinc finger superfamily

  2. XM_006507166.3 → XP_006507229.1  E3 ubiquitin-protein ligase TRIM68 isoform X1

    UniProtKB/Swiss-Prot
    Q8K243
    Conserved Domains (4) summary
    cd13733
    Location:303 → 478
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
    cd16610
    Location:13 → 61
    RING-HC_TRIM68_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 68 (TRIM68) and similar proteins
    pfam02335
    Location:112 → 188
    Cytochrom_C552; Cytochrome c552
    cl00034
    Location:96 → 138
    Bbox_SF; B-box-type zinc finger superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K243.1 GenPept UniProtKB/Swiss-Prot:Q8K243

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