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Vrk3 vaccinia related kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 101568, updated on 9-May-2024

Summary

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Official Symbol
Vrk3provided by MGI
Official Full Name
vaccinia related kinase 3provided by MGI
Primary source
MGI:MGI:2182465
See related
Ensembl:ENSMUSG00000002205 AllianceGenome:MGI:2182465
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables protein phosphatase binding activity. Acts upstream of or within negative regulation of ERK1 and ERK2 cascade and positive regulation of phosphoprotein phosphatase activity. Located in nucleus. Is expressed in several structures, including dorsal mesogastrium; hemolymphoid system; liver; metanephros; and yolk sac. Used to study autism spectrum disorder. Orthologous to human VRK3 (VRK serine/threonine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 35.9), large intestine adult (RPKM 18.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 B3; 7 28.9 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44398049..44426939)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44748629..44777515)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18813 Neighboring gene IZUMO family member 2 Neighboring gene zinc finger protein 473 Neighboring gene STARR-positive B cell enhancer ABC_E2823 Neighboring gene STARR-seq mESC enhancer starr_18814 Neighboring gene STARR-seq mESC enhancer starr_18815 Neighboring gene predicted gene, 29791 Neighboring gene STARR-seq mESC enhancer starr_18816 Neighboring gene STARR-positive B cell enhancer ABC_E1086 Neighboring gene activating transcription factor 5 Neighboring gene interleukin 4 induced 1B Neighboring gene nucleoporin 62

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Effect of tumour progression on the androgenic regulation of the androgen receptor, TRPM-2 and YPT1 genes in the Shionogi carcinoma. Rennie PS, et al. J Steroid Biochem Mol Biol, 1994 Jul. PMID 8049130
  2. Autism-like behavior caused by deletion of vaccinia-related kinase 3 is improved by TrkB stimulation. Kang MS, et al. J Exp Med, 2017 Oct 2. PMID 28899869, Free PMC Article
  3. Vaccinia-related kinase 3 (VRK3) sets the circadian period and amplitude by affecting the subcellular localization of clock proteins in mammalian cells. Park N, et al. Biochem Biophys Res Commun, 2017 May 27. PMID 28412365
  4. Presumed pseudokinase VRK3 functions as a BAF kinase. Park CH, et al. Biochim Biophys Acta, 2015 Jul. PMID 25899223
  5. Expression of the VRK (vaccinia-related kinase) gene family of p53 regulators in murine hematopoietic development. Vega FM, et al. FEBS Lett, 2003 Jun 5. PMID 12782311

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Stress-induced nuclear translocation of CDK5 suppresses neuronal death by downregulating ERK activation via VRK3 phosphorylation
    Title: Stress-induced nuclear translocation of CDK5 suppresses neuronal death by downregulating ERK activation via VRK3 phosphorylation.
  2. Finally, downregulation of hvrk3 using siRNA reduced the amplitude and lengthened the period of the cellular bioluminescence rhythm. Taken together, these data suggest that VRK3 plays a role in setting the amplitude and period length of circadian rhythms in mammalian cells.
    Title: Vaccinia-related kinase 3 (VRK3) sets the circadian period and amplitude by affecting the subcellular localization of clock proteins in mammalian cells.
  3. These data suggest that VRK3-mediated phosphorylation of BAF may facilitate DNA replication or gene expression by facilitating the dissociation of nuclear envelope proteins and chromatin during interphase.
    Title: Presumed pseudokinase VRK3 functions as a BAF kinase.
  4. various other rodent adult tissues and embryos possess a common signaling mechanism which is involved in an indirect regulation of ERK activity by VRK3-mediated vaccinia H1-related (VHR) phosphatase activity
    Title: VRK3-mediated inactivation of ERK signaling in adult and embryonic rodent tissues.
  5. VRK genes play a role during embryonic development of hematopoiesis
    Title: Expression of the VRK (vaccinia-related kinase) gene family of p53 regulators in murine hematopoietic development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of phosphoprotein phosphatase activity IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in skeletal muscle tissue development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase VRK3
Names
inactive serine/threonine-protein kinase VRK3
serine/threonine-protein pseudokinase VRK3
NP_001406082.1
NP_001406083.1
NP_001406084.1
NP_001406085.1
NP_001406086.1
NP_001406087.1
NP_001406088.1
NP_001406089.1
NP_598706.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419153.1 → NP_001406082.1  serine/threonine-protein kinase VRK3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC150895, AC158231

  2. NM_001419154.1 → NP_001406083.1  serine/threonine-protein kinase VRK3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC150895

  3. NM_001419155.1 → NP_001406084.1  serine/threonine-protein kinase VRK3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC150895
    Related
    ENSMUST00000136069.9

  4. NM_001419156.1 → NP_001406085.1  serine/threonine-protein kinase VRK3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC150895
    Related
    ENSMUST00000135783.2

  5. NM_001419157.1 → NP_001406086.1  serine/threonine-protein kinase VRK3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC150895, AC158231
    UniProtKB/Swiss-Prot
    Q8K3G5, Q921W6
    UniProtKB/TrEMBL
    Q3TAR6

  6. NM_001419158.1 → NP_001406087.1  serine/threonine-protein kinase VRK3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC150895, AC158231
    UniProtKB/Swiss-Prot
    Q8K3G5, Q921W6
    UniProtKB/TrEMBL
    Q3TAR6

  7. NM_001419159.1 → NP_001406088.1  serine/threonine-protein kinase VRK3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC150895, AC158231
    UniProtKB/Swiss-Prot
    Q8K3G5, Q921W6
    UniProtKB/TrEMBL
    Q3TAR6

  8. NM_001419160.1 → NP_001406089.1  serine/threonine-protein kinase VRK3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC150895

  9. NM_133945.2 → NP_598706.1  serine/threonine-protein kinase VRK3 isoform 1

    See identical proteins and their annotated locations for NP_598706.1

    Status: VALIDATED

    Source sequence(s)
    AC150895, AC158231
    Consensus CDS
    CCDS21214.1
    UniProtKB/Swiss-Prot
    Q8K3G5, Q921W6
    UniProtKB/TrEMBL
    Q3TAR6
    Related
    ENSMUSP00000002275.9, ENSMUST00000002275.15
    Conserved Domains (2) summary
    pfam13240
    Location:4 → 26
    zinc_ribbon_2; zinc-ribbon domain
    cl21453
    Location:134 → 436
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. NR_185025.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC150895, AC158231
    Related
    ENSMUST00000147952.9

  2. NR_185026.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC150895, AC158231

  3. NR_185027.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC150895, AC158231

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44398049..44426939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K3G5.2 GenPept UniProtKB/Swiss-Prot:Q8K3G5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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