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Klk9 kallikrein related-peptidase 9 [ Mus musculus (house mouse) ]

Gene ID: 101533, updated on 5-Mar-2024

Summary

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Official Symbol
Klk9provided by MGI
Official Full Name
kallikrein related-peptidase 9provided by MGI
Primary source
MGI:MGI:1921082
See related
Ensembl:ENSMUSG00000047884 AllianceGenome:MGI:1921082
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1200016C12Rik
Summary
Predicted to be active in secretory granule. Orthologous to human KLK9 (kallikrein related peptidase 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in stomach adult (RPKM 11.6) and lung adult (RPKM 2.5) See more
Orthologs
human all
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Genomic context

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Location:
7 B3; 7 28.26 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (43441048..43446182)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (43791625..43796758)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene kallikrein related-peptidase 11 Neighboring gene kallikrein related-peptidase 10 Neighboring gene kallikrein related-peptidase 8 Neighboring gene kallikrein related-peptidase 7 (chymotryptic, stratum corneum)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Differences in Kallikrein-related peptidase mRNA sequences and KLK6 enzyme activity between mouse strains. Murakami K, et al. Protein Pept Lett, 2014. PMID 25666037
  2. Human tissue kallikreins: physiologic roles and applications in cancer. Borgoño CA, et al. Mol Cancer Res, 2004 May. PMID 15192120
  3. Organization and evolution of the glandular kallikrein locus in Mus musculus. Olsson AY, et al. Biochem Biophys Res Commun, 2002 Nov 29. PMID 12437987
  4. Taxon-specific evolution of glandular kallikrein genes and identification of a progenitor of prostate-specific antigen. Olsson AY, et al. Genomics, 2004 Jul. PMID 15203212
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Clone Names

  • MGC130095, MGC130096

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kallikrein-9
Names
kallikrein 9
kallikrein-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028660.3 → NP_082936.2  kallikrein-9 precursor

    See identical proteins and their annotated locations for NP_082936.2

    Status: VALIDATED

    Source sequence(s)
    AI414707, AI536290, BC109326, BX520246
    Consensus CDS
    CCDS39937.1
    UniProtKB/TrEMBL
    A0A0B6VSQ8, Q32M27
    Related
    ENSMUSP00000005891.6, ENSMUST00000005891.7
    Conserved Domains (1) summary
    cd00190
    Location:24 → 247
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    43441048..43446182
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540537.4 → XP_006540600.1  kallikrein-9 isoform X1

    See identical proteins and their annotated locations for XP_006540600.1

    UniProtKB/TrEMBL
    A0A0B6VSQ8, Q32M27
    Conserved Domains (1) summary
    cd00190
    Location:24 → 247
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. XM_030241942.2 → XP_030097802.1  kallikrein-9 isoform X2

    Conserved Domains (1) summary
    smart00020
    Location:16 → 156
    Tryp_SPc; Trypsin-like serine protease
Nucleotide Protein Strain
Heading Accession and Version

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