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Plekha1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 [ Mus musculus (house mouse) ]

Gene ID: 101476, updated on 18-Apr-2024

Summary

Official Symbol
Plekha1provided by MGI
Official Full Name
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1provided by MGI
Primary source
MGI:MGI:2442213
See related
Ensembl:ENSMUSG00000040268 AllianceGenome:MGI:2442213
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TAPP1; C920009D07Rik
Summary
Predicted to enable PDZ domain binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Acts upstream of or within several processes, including cellular hormone metabolic process; face morphogenesis; and gonad development. Predicted to be located in cytosol; nucleoplasm; and ruffle membrane. Predicted to be active in cytoplasm and membrane. Is expressed in several structures, including ganglia; lung; metanephros; nasal epithelium; and ureter. Orthologous to human PLEKHA1 (pleckstrin homology domain containing A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 32.7), whole brain E14.5 (RPKM 25.8) and 26 other tissues See more
Orthologs
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Genomic context

Location:
7 F3; 7 73.19 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (130462281..130515224)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (130860551..130913494)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene BTB domain containing 16 Neighboring gene STARR-seq mESC enhancer starr_20267 Neighboring gene STARR-positive B cell enhancer ABC_E8213 Neighboring gene predicted gene, 53377 Neighboring gene predicted gene 5602 Neighboring gene STARR-seq mESC enhancer starr_20271 Neighboring gene microRNA 7061 Neighboring gene STARR-seq mESC enhancer starr_20273 Neighboring gene STARR-seq mESC enhancer starr_20276 Neighboring gene HtrA serine peptidase 1 Neighboring gene STARR-seq mESC enhancer starr_20277 Neighboring gene STARR-seq mESC enhancer starr_20278 Neighboring gene deleted in malignant brain tumors 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables PDZ domain binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-3,4-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within Leydig cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within androgen metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of protein localization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within estrogen metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within face morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within female gonad development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within luteinization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within roof of mouth development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ruffle organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
pleckstrin homology domain-containing family A member 1
Names
PH domain-containing family A member 1
TAPP-1
tandem PH domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346515.1NP_001333444.1  pleckstrin homology domain-containing family A member 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC115697
    Consensus CDS
    CCDS85434.1
    UniProtKB/Swiss-Prot
    Q8BK96, Q8BUL6, Q8BXU1, Q8VE13
    Conserved Domains (2) summary
    cd13270
    Location:1117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:185298
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
  2. NM_001357696.1NP_001344625.1  pleckstrin homology domain-containing family A member 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC115697
    Conserved Domains (2) summary
    cd13270
    Location:1117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:185296
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
  3. NM_001382373.1NP_001369302.1  pleckstrin homology domain-containing family A member 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC115697
    Conserved Domains (2) summary
    cd13270
    Location:1117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:185298
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
  4. NM_001382374.1NP_001369303.1  pleckstrin homology domain-containing family A member 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC115697
    UniProtKB/Swiss-Prot
    Q8BK96, Q8BUL6, Q8BXU1, Q8VE13
    Related
    ENSMUSP00000074675.5, ENSMUST00000075181.11
    Conserved Domains (2) summary
    cd13270
    Location:1117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:185298
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
  5. NM_001382375.1NP_001369304.1  pleckstrin homology domain-containing family A member 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC115697
    UniProtKB/TrEMBL
    D3YU01, D6RCU3
    Related
    ENSMUSP00000112777.2, ENSMUST00000120441.8
    Conserved Domains (2) summary
    cd13270
    Location:1117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:185298
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
  6. NM_001382376.1NP_001369305.1  pleckstrin homology domain-containing family A member 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC115697
    Conserved Domains (2) summary
    cd13270
    Location:1117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:185298
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
  7. NM_001382377.1NP_001369306.1  pleckstrin homology domain-containing family A member 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC115697
    UniProtKB/TrEMBL
    D6RCU3
    Conserved Domains (2) summary
    cd13271
    Location:137250
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    cl17171
    Location:175
    PH-like; Pleckstrin homology-like domain
  8. NM_001382378.1NP_001369307.1  pleckstrin homology domain-containing family A member 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC115697
    UniProtKB/TrEMBL
    D3YU01, D6RCU3
    Conserved Domains (2) summary
    cd13270
    Location:1117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:185298
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
  9. NM_001382379.1NP_001369308.1  pleckstrin homology domain-containing family A member 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC115697
    UniProtKB/TrEMBL
    D6RCU3
    Conserved Domains (2) summary
    cd13271
    Location:137250
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    cl17171
    Location:175
    PH-like; Pleckstrin homology-like domain
  10. NM_133942.3NP_598703.1  pleckstrin homology domain-containing family A member 1 isoform 1

    See identical proteins and their annotated locations for NP_598703.1

    Status: VALIDATED

    Source sequence(s)
    AC115697
    Consensus CDS
    CCDS21907.1
    UniProtKB/Swiss-Prot
    Q8BUL6
    Related
    ENSMUSP00000035375.6, ENSMUST00000048180.12
    Conserved Domains (3) summary
    cd13271
    Location:137250
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    pfam00169
    Location:144240
    PH; PH domain
    cl17171
    Location:175
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    130462281..130515224
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321904.2XP_017177393.1  pleckstrin homology domain-containing family A member 1 isoform X1

    Conserved Domains (2) summary
    cd13270
    Location:1117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:185296
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
  2. XM_006507152.2XP_006507215.1  pleckstrin homology domain-containing family A member 1 isoform X7

    UniProtKB/TrEMBL
    D6RCU3
    Conserved Domains (2) summary
    cd13270
    Location:1117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:185296
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
  3. XM_006507140.1XP_006507203.1  pleckstrin homology domain-containing family A member 1 isoform X1

    See identical proteins and their annotated locations for XP_006507203.1

    Conserved Domains (2) summary
    cd13270
    Location:1117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:185296
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
  4. XM_006507145.1XP_006507208.1  pleckstrin homology domain-containing family A member 1 isoform X2

    See identical proteins and their annotated locations for XP_006507208.1

    Conserved Domains (2) summary
    cd13270
    Location:1117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:185298
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
  5. XM_006507150.1XP_006507213.1  pleckstrin homology domain-containing family A member 1 isoform X6

    See identical proteins and their annotated locations for XP_006507213.1

    Conserved Domains (2) summary
    cd13271
    Location:137248
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    cl17171
    Location:175
    PH-like; Pleckstrin homology-like domain
  6. XM_036152519.1XP_036008412.1  pleckstrin homology domain-containing family A member 1 isoform X8

    Conserved Domains (2) summary
    cd13271
    Location:137250
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    cl17171
    Location:175
    PH-like; Pleckstrin homology-like domain
  7. XM_030241937.1XP_030097797.1  pleckstrin homology domain-containing family A member 1 isoform X9

    Conserved Domains (2) summary
    cd13271
    Location:137250
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    cl17171
    Location:175
    PH-like; Pleckstrin homology-like domain
  8. XM_006507151.5XP_006507214.1  pleckstrin homology domain-containing family A member 1 isoform X6

    See identical proteins and their annotated locations for XP_006507214.1

    Conserved Domains (2) summary
    cd13271
    Location:137248
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    cl17171
    Location:175
    PH-like; Pleckstrin homology-like domain
  9. XM_006507141.5XP_006507204.1  pleckstrin homology domain-containing family A member 1 isoform X1

    See identical proteins and their annotated locations for XP_006507204.1

    Conserved Domains (2) summary
    cd13270
    Location:1117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:185296
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
  10. XM_036152518.1XP_036008411.1  pleckstrin homology domain-containing family A member 1 isoform X4

    Conserved Domains (2) summary
    cd13270
    Location:1117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:185298
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
  11. XM_036152520.1XP_036008413.1  pleckstrin homology domain-containing family A member 1 isoform X9

    Conserved Domains (2) summary
    cd13271
    Location:137250
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    cl17171
    Location:175
    PH-like; Pleckstrin homology-like domain
  12. XM_036152517.1XP_036008410.1  pleckstrin homology domain-containing family A member 1 isoform X3

    Conserved Domains (2) summary
    cd13270
    Location:1117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:185296
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
  13. XM_030241935.2XP_030097795.1  pleckstrin homology domain-containing family A member 1 isoform X2

    Conserved Domains (2) summary
    cd13270
    Location:1117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:185298
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
  14. XM_030241936.2XP_030097796.1  pleckstrin homology domain-containing family A member 1 isoform X5

    UniProtKB/Swiss-Prot
    Q8BK96, Q8BUL6, Q8BXU1, Q8VE13
    Conserved Domains (2) summary
    cd13270
    Location:1117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:185298
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
  15. XM_006507143.5XP_006507206.1  pleckstrin homology domain-containing family A member 1 isoform X1

    See identical proteins and their annotated locations for XP_006507206.1

    Conserved Domains (2) summary
    cd13270
    Location:1117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:185296
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
  16. XM_006507142.4XP_006507205.1  pleckstrin homology domain-containing family A member 1 isoform X1

    See identical proteins and their annotated locations for XP_006507205.1

    Conserved Domains (2) summary
    cd13270
    Location:1117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:185296
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
  17. XM_036152521.1XP_036008414.1  pleckstrin homology domain-containing family A member 1 isoform X10

    Conserved Domains (2) summary
    cd13271
    Location:165278
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    cl17171
    Location:4897
    PH-like; Pleckstrin homology-like domain