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SUGP2 SURP and G-patch domain containing 2 [ Homo sapiens (human) ]

Gene ID: 10147, updated on 7-Apr-2024

Summary

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Official Symbol
SUGP2provided by HGNC
Official Full Name
SURP and G-patch domain containing 2provided by HGNC
Primary source
HGNC:HGNC:18641
See related
Ensembl:ENSG00000064607 MIM:607993; AllianceGenome:HGNC:18641
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SFRS14; SRFS14
Summary
This gene encodes a member of the arginine/serine-rich family of splicing factors. The encoded protein functions in mRNA processing. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]
Expression
Broad expression in testis (RPKM 45.5), brain (RPKM 19.3) and 24 other tissues See more
Orthologs
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Genomic context

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See SUGP2 in Genome Data Viewer
Location:
19p13.11
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (18990887..19033844, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (19126690..19169638, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (19101696..19144653, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10426 Neighboring gene homer scaffold protein 3 Neighboring gene HOMER3 antisense RNA 1 Neighboring gene RNA, 7SL, cytoplasmic 70, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:19088899-19089543 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:19100696-19101196 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:19136044-19137243 Neighboring gene NANOG hESC enhancer GRCh37_chr19:19143058-19143559 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:19162565-19163065 Neighboring gene armadillo repeat containing 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14335 Neighboring gene uncharacterized LOC124904655 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10429 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10430 Neighboring gene solute carrier family 25 member 42 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:19198769-19199269 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:19205587-19206086 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:19207400-19208599 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10431 Neighboring gene Sharpr-MPRA regulatory region 5014

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. SF4 and SFRS14, two related putative splicing factors on human chromosome 19p13.11. Sampson ND, et al. Gene, 2003 Feb 13. PMID 12594045
  2. The WTX Tumor Suppressor Interacts with the Transcriptional Corepressor TRIM28. Kim WJ, et al. J Biol Chem, 2015 Jun 5. PMID 25882849, Free PMC Article
  3. Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation. Chen Z, et al. Cell Death Differ, 2022 Oct. PMID 35379950, Free PMC Article
  4. EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis. Béguelin W, et al. Cancer Cell, 2016 Aug 8. PMID 27505670, Free PMC Article
  5. FBXO22 degrades nuclear PTEN to promote tumorigenesis. Ge MK, et al. Nat Commun, 2020 Apr 6. PMID 32249768, Free PMC Article

See all (96) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ21855, DKFZp686M2322, DKFZp779L2418

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
SURP and G-patch domain-containing protein 2
Names
arginine/serine-rich-splicing factor 14
splicing factor, arginine/serine-rich 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017392.5 → NP_001017392.2  SURP and G-patch domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001017392.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the shorter isoform (1). Variants 1-4 encode the same isoform (1).
    Source sequence(s)
    AC004447, AL832488, BG166266, BX647813, DC335817
    Consensus CDS
    CCDS12392.1
    UniProtKB/Swiss-Prot
    C9JI71, O15071, O60369, Q5JPH7, Q8IX01, Q8WUF7
    UniProtKB/TrEMBL
    A8K5G0
    Related
    ENSP00000389380.1, ENST00000452918.7
    Conserved Domains (3) summary
    smart00443
    Location:1009 → 1054
    G_patch; glycine rich nucleic binding domain
    smart00648
    Location:785 → 838
    SWAP; Suppressor-of-White-APricot splicing regulator
    cl02715
    Location:589 → 639
    Surp; Surp module

  2. NM_001321697.2 → NP_001308626.1  SURP and G-patch domain-containing protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC004447, BG166266, DA770920
    Consensus CDS
    CCDS12392.1
    UniProtKB/Swiss-Prot
    C9JI71, O15071, O60369, Q5JPH7, Q8IX01, Q8WUF7
    UniProtKB/TrEMBL
    A8K5G0
    Related
    ENSP00000470915.1, ENST00000594773.5
    Conserved Domains (3) summary
    smart00443
    Location:1009 → 1054
    G_patch; glycine rich nucleic binding domain
    smart00648
    Location:785 → 838
    SWAP; Suppressor-of-White-APricot splicing regulator
    cl02715
    Location:589 → 639
    Surp; Surp module

  3. NM_001321698.1 → NP_001308627.1  SURP and G-patch domain-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC004447, BG166266
    Consensus CDS
    CCDS82322.1
    UniProtKB/TrEMBL
    A8K5G0, M0R2Z9
    Conserved Domains (3) summary
    smart00443
    Location:1023 → 1068
    G_patch; glycine rich nucleic binding domain
    smart00648
    Location:799 → 852
    SWAP; Suppressor-of-White-APricot splicing regulator
    cl02715
    Location:603 → 653
    Surp; Surp module

  4. NM_001321699.1 → NP_001308628.1  SURP and G-patch domain-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC004447, BG166266, DC402794
    Consensus CDS
    CCDS82322.1
    UniProtKB/TrEMBL
    A8K5G0, M0R2Z9
    Conserved Domains (3) summary
    smart00443
    Location:1023 → 1068
    G_patch; glycine rich nucleic binding domain
    smart00648
    Location:799 → 852
    SWAP; Suppressor-of-White-APricot splicing regulator
    cl02715
    Location:603 → 653
    Surp; Surp module

  5. NM_001352071.2 → NP_001339000.1  SURP and G-patch domain-containing protein 2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same isoform (1).
    Source sequence(s)
    AC004447, AL832488, BG166266, BX647813, DA240141
    Consensus CDS
    CCDS12392.1
    UniProtKB/Swiss-Prot
    C9JI71, O15071, O60369, Q5JPH7, Q8IX01, Q8WUF7
    UniProtKB/TrEMBL
    A8K5G0
    Related
    ENSP00000472286.1, ENST00000601879.5
    Conserved Domains (3) summary
    smart00443
    Location:1009 → 1054
    G_patch; glycine rich nucleic binding domain
    smart00648
    Location:785 → 838
    SWAP; Suppressor-of-White-APricot splicing regulator
    cl02715
    Location:589 → 639
    Surp; Surp module

  6. NM_014884.5 → NP_055699.2  SURP and G-patch domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_055699.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1-4 encode the same isoform (1).
    Source sequence(s)
    AF518874, AK291275
    Consensus CDS
    CCDS12392.1
    UniProtKB/Swiss-Prot
    C9JI71, O15071, O60369, Q5JPH7, Q8IX01, Q8WUF7
    UniProtKB/TrEMBL
    A8K5G0
    Related
    ENSP00000337926.5, ENST00000337018.10
    Conserved Domains (3) summary
    smart00443
    Location:1009 → 1054
    G_patch; glycine rich nucleic binding domain
    smart00648
    Location:785 → 838
    SWAP; Suppressor-of-White-APricot splicing regulator
    cl02715
    Location:589 → 639
    Surp; Surp module

RNA

  1. NR_147913.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004447, AF518874, AK291275, BE166620, BG166266, CA422995, CB160925

  2. NR_147914.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AF518874, AK291275, BU730975

  3. NR_147915.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AA505711, AC004447, AF518874, AK291275, BE622050, BG166266, CA422995, DA240141

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    18990887..19033844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438023.1 → XP_047293979.1  SURP and G-patch domain-containing protein 2 isoform X3

  2. XM_024451308.2 → XP_024307076.1  SURP and G-patch domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A8K5G0, M0R2Z9
    Related
    ENSP00000472914.1, ENST00000600377.1
    Conserved Domains (3) summary
    smart00443
    Location:1023 → 1068
    G_patch; glycine rich nucleic binding domain
    smart00648
    Location:799 → 852
    SWAP; Suppressor-of-White-APricot splicing regulator
    cl02715
    Location:603 → 653
    Surp; Surp module

  3. XM_024451307.2 → XP_024307075.1  SURP and G-patch domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A8K5G0
    Conserved Domains (3) summary
    smart00648
    Location:799 → 852
    SWAP; Suppressor-of-White-APricot splicing regulator
    pfam01585
    Location:1026 → 1057
    G-patch; G-patch domain
    cl02715
    Location:603 → 653
    Surp; Surp module

  4. XM_047438022.1 → XP_047293978.1  SURP and G-patch domain-containing protein 2 isoform X3

  5. XM_047438027.1 → XP_047293983.1  SURP and G-patch domain-containing protein 2 isoform X3

  6. XM_047438025.1 → XP_047293981.1  SURP and G-patch domain-containing protein 2 isoform X4

  7. XM_047438026.1 → XP_047293982.1  SURP and G-patch domain-containing protein 2 isoform X5

RNA

  1. XR_430124.5 RNA Sequence

  2. XR_001753576.3 RNA Sequence

  3. XR_007066515.1 RNA Sequence

  4. XR_430122.5 RNA Sequence

  5. XR_002958236.2 RNA Sequence

  6. XR_007066514.1 RNA Sequence

  7. XR_007066517.1 RNA Sequence

  8. XR_007066519.1 RNA Sequence

  9. XR_007066518.1 RNA Sequence

  10. XR_007066512.1 RNA Sequence

  11. XR_007066530.1 RNA Sequence

  12. XR_007066523.1 RNA Sequence

  13. XR_007066526.1 RNA Sequence

  14. XR_007066525.1 RNA Sequence

  15. XR_007066527.1 RNA Sequence

  16. XR_007066524.1 RNA Sequence

  17. XR_007066520.1 RNA Sequence

  18. XR_007066528.1 RNA Sequence

  19. XR_007066529.1 RNA Sequence

  20. XR_007066521.1 RNA Sequence

  21. XR_007066531.1 RNA Sequence

  22. XR_007066513.1 RNA Sequence

  23. XR_007066516.1 RNA Sequence

  24. XR_007066522.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    19126690..19169638 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319490.1 → XP_054175465.1  SURP and G-patch domain-containing protein 2 isoform X3

  2. XM_054319488.1 → XP_054175463.1  SURP and G-patch domain-containing protein 2 isoform X2

  3. XM_054319487.1 → XP_054175462.1  SURP and G-patch domain-containing protein 2 isoform X1

  4. XM_054319489.1 → XP_054175464.1  SURP and G-patch domain-containing protein 2 isoform X3

  5. XM_054319493.1 → XP_054175468.1  SURP and G-patch domain-containing protein 2 isoform X3

  6. XM_054319491.1 → XP_054175466.1  SURP and G-patch domain-containing protein 2 isoform X4

  7. XM_054319492.1 → XP_054175467.1  SURP and G-patch domain-containing protein 2 isoform X5

RNA

  1. XR_008485044.1 RNA Sequence

  2. XR_008485047.1 RNA Sequence

  3. XR_008485042.1 RNA Sequence

  4. XR_008485043.1 RNA Sequence

  5. XR_008485046.1 RNA Sequence

  6. XR_008485041.1 RNA Sequence

  7. XR_008485048.1 RNA Sequence

  8. XR_008485050.1 RNA Sequence

  9. XR_008485049.1 RNA Sequence

  10. XR_008485039.1 RNA Sequence

  11. XR_008485061.1 RNA Sequence

  12. XR_008485054.1 RNA Sequence

  13. XR_008485057.1 RNA Sequence

  14. XR_008485056.1 RNA Sequence

  15. XR_008485058.1 RNA Sequence

  16. XR_008485055.1 RNA Sequence

  17. XR_008485051.1 RNA Sequence

  18. XR_008485059.1 RNA Sequence

  19. XR_008485060.1 RNA Sequence

  20. XR_008485052.1 RNA Sequence

  21. XR_008485062.1 RNA Sequence

  22. XR_008485040.1 RNA Sequence

  23. XR_008485045.1 RNA Sequence

  24. XR_008485053.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IX01.2 GenPept UniProtKB/Swiss-Prot:Q8IX01

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