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Fbxl14 F-box and leucine-rich repeat protein 14 [ Mus musculus (house mouse) ]

Gene ID: 101358, updated on 5-Mar-2024

Summary

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Official Symbol
Fbxl14provided by MGI
Official Full Name
F-box and leucine-rich repeat protein 14provided by MGI
Primary source
MGI:MGI:2141676
See related
Ensembl:ENSMUSG00000030019 AllianceGenome:MGI:2141676
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fbx14l
Summary
Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human FBXL14 (F-box and leucine rich repeat protein 14). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human all
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Genomic context

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Location:
6 F1; 6 56.86 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (119456629..119460847)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (119479668..119483886)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene adiponectin receptor 2 Neighboring gene STARR-positive B cell enhancer ABC_E9099 Neighboring gene STARR-seq mESC enhancer starr_17147 Neighboring gene STARR-seq mESC enhancer starr_17149 Neighboring gene wingless-type MMTV integration site family, member 5B Neighboring gene predicted gene, 40397 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:119472087-119472240 Neighboring gene predicted gene, 30690 Neighboring gene predicted gene, 52875

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The E3 ubiquitin ligase SCF(FBXL14) complex stimulates neuronal differentiation by targeting the Notch signaling factor HES1 for proteolysis. Chen F, et al. J Biol Chem, 2017 Dec 8. PMID 29070679, Free PMC Article
  2. The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation. Viñas-Castells R, et al. J Biol Chem, 2010 Feb 5. PMID 19955572, Free PMC Article
  3. A conserved F-box gene with unusual transcript localization. Das T, et al. Dev Genes Evol, 2002 Apr. PMID 11976951
  4. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, et al. Genes Dev, 2004 Nov 1. PMID 15520277, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results suggest that SCF(FBXL14) promotes neuronal differentiation by targeting HES1 for ubiquitin-dependent proteolysis and that the C-terminal WRPW motif in HES1 is required for this process
    Title: The E3 ubiquitin ligase SCF(FBXL14) complex stimulates neuronal differentiation by targeting the Notch signaling factor HES1 for proteolysis.
  2. Data show that Twist1 small interfering RNA prevents hypoxia-induced Fbxl14 down-regulation and SNAIL1 stabilization.
    Title: The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
F-box/LRR-repeat protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133940.3 → NP_598701.2  F-box/LRR-repeat protein 14

    See identical proteins and their annotated locations for NP_598701.2

    Status: VALIDATED

    Source sequence(s)
    AC126607
    Consensus CDS
    CCDS20475.1
    UniProtKB/Swiss-Prot
    Q3U2Q9, Q8BID8, Q8R5H7, Q8VDT7, Q922N5
    Related
    ENSMUSP00000032094.6, ENSMUST00000032094.7
    Conserved Domains (3) summary
    cd09293
    Location:228 → 395
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:145 → 170
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:5 → 46
    F-box-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    119456629..119460847
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BID8.1 GenPept UniProtKB/Swiss-Prot:Q8BID8

Gene LinkOut

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