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Eogt EGF domain specific O-linked N-acetylglucosamine transferase [ Mus musculus (house mouse) ]

Gene ID: 101351, updated on 12-Mar-2024

Summary

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Official Symbol
Eogtprovided by MGI
Official Full Name
EGF domain specific O-linked N-acetylglucosamine transferaseprovided by MGI
Primary source
MGI:MGI:2141669
See related
Ensembl:ENSMUSG00000035245 AllianceGenome:MGI:2141669
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Aer61; A130022J15Rik
Summary
Enables protein N-acetylglucosaminyltransferase activity. Involved in protein O-linked glycosylation. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum lumen. Is expressed in several structures, including blood vessel; central nervous system; limb; lung; and tail unsegmented mesenchyme. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome. Orthologous to human EOGT (EGF domain specific O-linked N-acetylglucosamine transferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 7.7), bladder adult (RPKM 7.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Eogt in Genome Data Viewer
Location:
6 D3; 6 44.88 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (97086977..97128445, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (97110016..97151484, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene TAFA chemokine like family member 1 Neighboring gene STARR-seq mESC enhancer starr_16762 Neighboring gene predicted gene, 26011 Neighboring gene STARR-seq mESC enhancer starr_16763 Neighboring gene STARR-seq mESC enhancer starr_16764 Neighboring gene STARR-seq mESC enhancer starr_16765 Neighboring gene STARR-seq mESC enhancer starr_16766 Neighboring gene TAFA chemokine like family member 4 Neighboring gene STARR-seq mESC enhancer starr_16767 Neighboring gene STARR-seq mESC enhancer starr_16770 Neighboring gene STARR-seq mESC enhancer starr_16771 Neighboring gene STARR-seq mESC enhancer starr_16773 Neighboring gene STARR-seq mESC enhancer starr_16775 Neighboring gene STARR-seq mESC enhancer starr_16776 Neighboring gene STARR-positive B cell enhancer ABC_E2796 Neighboring gene predicted gene, 26175 Neighboring gene TATA element modulatory factor 1 Neighboring gene ubiquitin-like modifier activating enzyme 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. N-Glycans on EGF domain-specific O-GlcNAc transferase (EOGT) facilitate EOGT maturation and peripheral endoplasmic reticulum localization. Alam SMD, et al. J Biol Chem, 2020 Jun 19. PMID 32376684, Free PMC Article
  2. Mutations in EOGT confirm the genetic heterogeneity of autosomal-recessive Adams-Oliver syndrome. Shaheen R, et al. Am J Hum Genet, 2013 Apr 4. PMID 23522784, Free PMC Article
  3. O-linked-N-acetylglucosamine modification of mammalian Notch receptors by an atypical O-GlcNAc transferase Eogt1. Sakaidani Y, et al. Biochem Biophys Res Commun, 2012 Mar 2. PMID 22310717
  4. O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals. Sawaguchi S, et al. Elife, 2017 Apr 11. PMID 28395734, Free PMC Article
  5. Cyclical expression of the Notch/Wnt regulator Nrarp requires modulation by Dll3 in somitogenesis. Sewell W, et al. Dev Biol, 2009 May 15. PMID 19268448, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EOGT enables residual Notch signaling in mouse intestinal cells lacking POFUT1.
    Title: EOGT enables residual Notch signaling in mouse intestinal cells lacking POFUT1.
  2. N-Glycans on EGF domain-specific O-GlcNAc transferase (EOGT) facilitate EOGT maturation and peripheral endoplasmic reticulum localization.
    Title: N-Glycans on EGF domain-specific O-GlcNAc transferase (EOGT) facilitate EOGT maturation and peripheral endoplasmic reticulum localization.
  3. the characterization of A130022J15Rik, a mouse gene homolog of Drosophila Eogt (Eogt 1), was reported.
    Title: O-linked-N-acetylglucosamine modification of mammalian Notch receptors by an atypical O-GlcNAc transferase Eogt1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein O-acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein O-acetylglucosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein O-GlcNAcylation via threonine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum lumen IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
EGF domain-specific O-linked N-acetylglucosamine transferase
Names
EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
extracellular O-linked N-acetylglucosamine transferase
NP_780522.1
XP_036021602.1
XP_036021603.1
XP_036021604.1
XP_036021605.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175313.5 → NP_780522.1  EGF domain-specific O-linked N-acetylglucosamine transferase precursor

    See identical proteins and their annotated locations for NP_780522.1

    Status: VALIDATED

    Source sequence(s)
    AC155727
    Consensus CDS
    CCDS20383.1
    UniProtKB/Swiss-Prot
    Q8BYW9
    Related
    ENSMUSP00000061610.5, ENSMUST00000054344.11
    Conserved Domains (1) summary
    pfam04577
    Location:245 → 469
    DUF563; Protein of unknown function (DUF563)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    97086977..97128445 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165709.1 → XP_036021602.1  EGF domain-specific O-linked N-acetylglucosamine transferase isoform X1

    Conserved Domains (1) summary
    pfam04577
    Location:245 → 473
    DUF563; Protein of unknown function (DUF563)

  2. XM_036165712.1 → XP_036021605.1  EGF domain-specific O-linked N-acetylglucosamine transferase isoform X3

    Conserved Domains (1) summary
    pfam04577
    Location:2 → 228
    DUF563; Protein of unknown function (DUF563)

  3. XM_036165711.1 → XP_036021604.1  EGF domain-specific O-linked N-acetylglucosamine transferase isoform X2

    UniProtKB/Swiss-Prot
    Q8BYW9
    Conserved Domains (1) summary
    pfam04577
    Location:245 → 469
    DUF563; Protein of unknown function (DUF563)

  4. XM_036165710.1 → XP_036021603.1  EGF domain-specific O-linked N-acetylglucosamine transferase isoform X1

    Conserved Domains (1) summary
    pfam04577
    Location:245 → 473
    DUF563; Protein of unknown function (DUF563)

RNA

  1. XR_004942885.1 RNA Sequence

  2. XR_377399.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BYW9.1 GenPept UniProtKB/Swiss-Prot:Q8BYW9

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