NPTN-IT1 NPTN intronic transcript 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NPTN-IT1provided by HGNC
Official Full Name: NPTN intronic transcript 1provided by HGNC
Primary source: HGNC:HGNC:45091
See related: Ensembl:ENSG00000281183 MIM:615176; AllianceGenome:HGNC:45091
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: lncRNA-LET
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Genomic context

Location:: 15q24.1

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (73566938..73569543, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (71384093..71386694, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (73859279..73861884, complement)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The expression of lncRNA LET was reduced in breast cancer tissues and MDA-MB-231 cell line. lncRNA LET expression plays a key role in the proliferation, invasion and migration of breast cancer cells. It is a new type of molecule involved in the development of breast cancer.
Title: LncRNA LET function as a tumor suppressor in breast cancer development.
Overexpression of lncRNA-LET inhibits cell viability, migration and EMT process, and increases apoptosis in KGN cells.
Title: LncRNA-LET inhibits cell viability, migration and EMT while induces apoptosis by up-regulation of TIMP2 in human granulosa-like tumor cell line KGN.
Decreased lncRNA LET expression was detected in burn tissues compared with normal skin.
Title: EZH2-mediated suppression of lncRNA-LET promotes cell apoptosis and inhibits the proliferation of post-burn skin fibroblasts.
lncRNA-LET exhibits an important tumor-suppressive effect on Lung Adenocarcinoma progression by inhibiting EMT and Wnt/beta-catenin pathway, which provides potential therapeutic targets for Lung Adenocarcinoma.
Title: Long Noncoding RNA-LET Suppresses Tumor Growth and EMT in Lung Adenocarcinoma.
The role of lncRNA-LET as a regulator of hypoxia signaling in hepatocellular carcinoma.
Title: Repression of the long noncoding RNA-LET by histone deacetylase 3 contributes to hypoxia-mediated metastasis.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

SHGC-24300 (e-PCR)
- UniSTS:80557

D15S904 (e-PCR)
- UniSTS:1505

Other Names

NPTN intronic transcript 1 (non-protein coding)
long non-coding RNA, low expression in tumor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.