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LSINCT5 long stress-induced non-coding transcript 5 [ Homo sapiens (human) ]

Gene ID: 101234261, updated on 10-Oct-2023

Summary

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Official Symbol
LSINCT5provided by HGNC
Official Full Name
long stress-induced non-coding transcript 5provided by HGNC
Primary source
HGNC:HGNC:37824
See related
Ensembl:ENSG00000281560 MIM:615764; AllianceGenome:HGNC:37824
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
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Genomic context

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Location:
5p15.33
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (2712591..2715237)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (2627590..2630236)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (2712705..2715351)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100506858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:2353718-2354218 Neighboring gene NANOG hESC enhancer GRCh37_chr5:2359276-2359777 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:2393157-2394356 Neighboring gene uncharacterized LOC124901167 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_84195 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_84199 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:2591788-2592348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:2592349-2592909 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:2635417-2636236 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:2640855-2641373 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:2655710-2656909 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:2658151-2659350 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:2663143-2663330 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:2696278-2696794 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:2697069-2698268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:2709931-2710432 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:2747930-2748875 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:2748876-2749820 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:2751906-2752830 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:2756718-2757670 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:2757671-2758621 Neighboring gene IRX2 divergent transcript Neighboring gene iroquois homeobox 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. LSINCT5: A Novel lncRNA in Cancers. Qiu X, et al. Curr Med Chem, 2023. PMID 36734894
  2. LncRNA LSINCT5 drives proliferation and migration of oral squamous cell carcinoma through the miRNA-185-5p/ZNF703 axis. Wang X, et al. J BUON, 2021 Jan-Feb. PMID 33721442
  3. Effect of long non-coding RNA long stress-induced noncoding transcript 5 on erlotinib resistance to lung cancer cells and the underlying mechanisms. Chen Y, et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2020 Aug 28. PMID 33053528
  4. Long noncoding RNA LSINCT5 is upregulated and promotes the progression of esophageal squamous cell carcinoma. Jing L, et al. Eur Rev Med Pharmacol Sci, 2019 Jun. PMID 31298370
  5. LSINCT5 predicts unfavorable prognosis and exerts oncogenic function in osteosarcoma. He W, et al. Biosci Rep, 2019 May 31. PMID 30967495, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LSINCT5: A Novel lncRNA in Cancers.
    Title: LSINCT5: A Novel lncRNA in Cancers.
  2. LncRNA LSINCT5/miR-222 regulates myocardial ischemiareperfusion injury through PI3K/AKT pathway.
    Title: LncRNA LSINCT5/miR-222 regulates myocardial ischemia‑reperfusion injury through PI3K/AKT pathway.
  3. LncRNA LSINCT5 drives proliferation and migration of oral squamous cell carcinoma through the miRNA-185-5p/ZNF703 axis.
    Title: LncRNA LSINCT5 drives proliferation and migration of oral squamous cell carcinoma through the miRNA-185-5p/ZNF703 axis.
  4. Effect of long non-coding RNA long stress-induced noncoding transcript 5 on erlotinib resistance to lung cancer cells and the underlying mechanisms.", trans "RNA5.
    Title: Effect of long non-coding RNA long stress-induced noncoding transcript 5 on erlotinib resistance to lung cancer cells and the underlying mechanisms.
  5. Long noncoding RNA LSINCT5 is upregulated and promotes the progression of esophageal squamous cell carcinoma.
    Title: Long noncoding RNA LSINCT5 is upregulated and promotes the progression of esophageal squamous cell carcinoma.
  6. study suggests that LSINCT5 exerts oncogenic function in osteosarcoma cells, and may be a potential predictor for clinical outcome in osteosarcoma patients.
    Title: LSINCT5 predicts unfavorable prognosis and exerts oncogenic function in osteosarcoma.
  7. Down-regulation of LSINCT5 represses glioma cells growth and metastasis in vitro likely through targeting miR-451 and thereby inhibiting Rac1-regulated PI3K/AKT, Wnt/beta-catenin and NF-kappaB pathways
    Title: Knockdown of lncRNA LSINCT5 suppresses growth and metastasis of human glioma cells via up-regulating miR-451.
  8. LSINCT5 may possibly contribute to non-small cell lung cancer tumorigenesis by stabilizing the oncogenic factor of HMGA2.
    Title: The long non-coding RNA LSINCT5 promotes malignancy in non-small cell lung cancer by stabilizing HMGA2.
  9. The expression levels of LSINCT5 was related to the body mass index in women.
    Title: Expression levels of breast cancer-related GAS5 and LSINCT5 lncRNAs in cancer-free breast tissue: Molecular associations with age at menarche and obesity.
  10. LSINCT5 interacted with EZH2 to suppress the expression of APC, a negative regulator of the Wnt/beta-catenin pathway.
    Title: Long noncoding RNA LSINCT5 acts as an oncogene via increasing EZH2-induced inhibition of APC expression in osteosarcoma.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Genotypes

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_145480.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    GU228577
    Related
    ENST00000626215.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    2712591..2715237
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    2627590..2630236
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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