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Tra2a transformer 2 alpha [ Mus musculus (house mouse) ]

Gene ID: 101214, updated on 3-Apr-2024

Summary

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Official Symbol
Tra2aprovided by MGI
Official Full Name
transformer 2 alphaprovided by MGI
Primary source
MGI:MGI:1933972
See related
Ensembl:ENSMUSG00000029817 AllianceGenome:MGI:1933972
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mAWMS1; Tra2alpha; TRA2-alpha; TRA-2 alpha; 1500010G04Rik; G430041M01Rik
Summary
Enables identical protein binding activity. Acts upstream of or within positive regulation of mRNA splicing, via spliceosome. Located in nucleus. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; olfactory epithelium; and retina. Orthologous to human TRA2A (transformer 2 alpha homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 66.1), CNS E14 (RPKM 56.3) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Tra2a in Genome Data Viewer
Location:
6 B2.3; 6 23.84 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (49220855..49241182, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (49243921..49264248, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene insulin-like growth factor 2 mRNA binding protein 3 Neighboring gene STARR-seq mESC enhancer starr_15813 Neighboring gene predicted gene, 18010 Neighboring gene RIKEN cDNA D030074P21 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:49158708-49158891 Neighboring gene STARR-positive B cell enhancer mm9_chr6:49186372-49186673 Neighboring gene STARR-positive B cell enhancer mm9_chr6:49214021-49214322 Neighboring gene STARR-seq mESC enhancer starr_15823 Neighboring gene STARR-seq mESC enhancer starr_15824 Neighboring gene STARR-seq mESC enhancer starr_15825 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1321 Neighboring gene coiled-coil domain containing 126

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tra2alpha promotes RA induced neural differentiation of P19 cells. Chen X, et al. Neurochem Res, 2005 Feb. PMID 15895831
  2. cDNA cloning and mRNA expression of Transformer 2 (Tra 2) in chicken embryo. Yamamoto I, et al. Biochim Biophys Acta, 2002 Dec 12. PMID 12427554
  3. Exonic splicing enhancer-dependent splicing of the gonadotropin-releasing hormone premessenger ribonucleic acid is mediated by tra2alpha, a 40-kilodalton serine/arginine-rich protein. Seong JY, et al. Mol Endocrinol, 2002 Nov. PMID 12403832
  4. Angulin proteins ILDR1 and ILDR2 regulate alternative pre-mRNA splicing through binding to splicing factors TRA2A, TRA2B, or SRSF1. Liu Y, et al. Sci Rep, 2017 Aug 7. PMID 28785060, Free PMC Article
  5. Identification of evolutionarily conserved exons as regulated targets for the splicing activator tra2β in development. Grellscheid S, et al. PLoS Genet, 2011 Dec. PMID 22194695, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. interaction of Tra2alpha with 9G8 and SRp30c appears to be crucial for ESE-dependent GnRH pre-mRNA splicing, allowing efficient generation of mature mRNA in GnRH-producing cells
    Title: Cooperative actions of Tra2alpha with 9G8 and SRp30c in the RNA splicing of the gonadotropin-releasing hormone gene transcript.
  2. exonic splicing enhancer-dependent splicing of GnRH mRNA is mediated by tra2alpha
    Title: Exonic splicing enhancer-dependent splicing of the gonadotropin-releasing hormone premessenger ribonucleic acid is mediated by tra2alpha, a 40-kilodalton serine/arginine-rich protein.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transformer-2 protein homolog alpha
Names
nuclear transformer-2 alpha
transformer 2 alpha homolog
transformer-2 protein homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347209.2 → NP_001334138.1  transformer-2 protein homolog alpha isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC158667
    Consensus CDS
    CCDS85044.1
    UniProtKB/Swiss-Prot
    Q6PFR5
    UniProtKB/TrEMBL
    A0A0N4SVC2
    Related
    ENSMUSP00000145039.2, ENSMUST00000204189.3
    Conserved Domains (1) summary
    cd12363
    Location:116 → 195
    RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

  2. NM_001362188.2 → NP_001349117.1  transformer-2 protein homolog alpha isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC158667
    Conserved Domains (1) summary
    cd12363
    Location:17 → 96
    RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

  3. NM_001406117.1 → NP_001393046.1  transformer-2 protein homolog alpha isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC158667

  4. NM_001406118.1 → NP_001393047.1  transformer-2 protein homolog alpha isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC158667

  5. NM_001406119.1 → NP_001393048.1  transformer-2 protein homolog alpha isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC158667

  6. NM_001406120.1 → NP_001393049.1  transformer-2 protein homolog alpha isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC158667

  7. NM_001406121.1 → NP_001393050.1  transformer-2 protein homolog alpha isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC158667

  8. NM_001406122.1 → NP_001393051.1  transformer-2 protein homolog alpha isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC158667

  9. NM_001406123.1 → NP_001393052.1  transformer-2 protein homolog alpha isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC158667

  10. NM_001406124.1 → NP_001393053.1  transformer-2 protein homolog alpha isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC158667

  11. NM_001406125.1 → NP_001393054.1  transformer-2 protein homolog alpha isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC158667
    Conserved Domains (1) summary
    cd12363
    Location:116 → 195
    RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

  12. NM_001406126.1 → NP_001393055.1  transformer-2 protein homolog alpha isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC158667

  13. NM_001406127.1 → NP_001393056.1  transformer-2 protein homolog alpha isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC158667

  14. NM_001406128.1 → NP_001393057.1  transformer-2 protein homolog alpha isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC158667

  15. NM_001406129.1 → NP_001393058.1  transformer-2 protein homolog alpha isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC158667

  16. NM_001406130.1 → NP_001393059.1  transformer-2 protein homolog alpha isoform 17

    Status: VALIDATED

    Source sequence(s)
    AC158667

  17. NM_001406131.1 → NP_001393060.1  transformer-2 protein homolog alpha isoform 18

    Status: VALIDATED

    Source sequence(s)
    AC158667

  18. NM_001406132.1 → NP_001393061.1  transformer-2 protein homolog alpha isoform 19

    Status: VALIDATED

    Source sequence(s)
    AC158667

  19. NM_001406133.1 → NP_001393062.1  transformer-2 protein homolog alpha isoform 20

    Status: VALIDATED

    Source sequence(s)
    AC158667
    Conserved Domains (1) summary
    cd12363
    Location:116 → 195
    RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

  20. NM_001406134.1 → NP_001393063.1  transformer-2 protein homolog alpha isoform 21

    Status: VALIDATED

    Source sequence(s)
    AC158667

  21. NM_001406135.1 → NP_001393064.1  transformer-2 protein homolog alpha isoform 22

    Status: VALIDATED

    Source sequence(s)
    AC158667

  22. NM_001406136.1 → NP_001393065.1  transformer-2 protein homolog alpha isoform 23

    Status: VALIDATED

    Source sequence(s)
    AC158667

  23. NM_001406137.1 → NP_001393066.1  transformer-2 protein homolog alpha isoform 24

    Status: VALIDATED

    Source sequence(s)
    AC158667

  24. NM_001406138.1 → NP_001393067.1  transformer-2 protein homolog alpha isoform 25

    Status: VALIDATED

    Source sequence(s)
    AC158667

  25. NM_001406139.1 → NP_001393068.1  transformer-2 protein homolog alpha isoform 26

    Status: VALIDATED

    Source sequence(s)
    AC158667

  26. NM_001406140.1 → NP_001393069.1  transformer-2 protein homolog alpha isoform 27

    Status: VALIDATED

    Source sequence(s)
    AC158667

  27. NM_001406141.1 → NP_001393070.1  transformer-2 protein homolog alpha isoform 28

    Status: VALIDATED

    Source sequence(s)
    AC158667

  28. NM_001406142.1 → NP_001393071.1  transformer-2 protein homolog alpha isoform 29

    Status: VALIDATED

    Source sequence(s)
    AC158667

  29. NM_001406143.1 → NP_001393072.1  transformer-2 protein homolog alpha isoform 30

    Status: VALIDATED

    Source sequence(s)
    AC158667

  30. NM_001406144.1 → NP_001393073.1  transformer-2 protein homolog alpha isoform 31

    Status: VALIDATED

    Source sequence(s)
    AC158667

  31. NM_001406145.1 → NP_001393074.1  transformer-2 protein homolog alpha isoform 32

    Status: VALIDATED

    Source sequence(s)
    AC158667

  32. NM_001406146.1 → NP_001393075.1  transformer-2 protein homolog alpha isoform 33

    Status: VALIDATED

    Source sequence(s)
    AC158667

  33. NM_001406147.1 → NP_001393076.1  transformer-2 protein homolog alpha isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC158667

  34. NM_001406149.1 → NP_001393078.1  transformer-2 protein homolog alpha isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC158667

  35. NM_001406150.1 → NP_001393079.1  transformer-2 protein homolog alpha isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC158667

  36. NM_001406151.1 → NP_001393080.1  transformer-2 protein homolog alpha isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC158667

  37. NM_001406152.1 → NP_001393081.1  transformer-2 protein homolog alpha isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC158667

  38. NM_001406153.1 → NP_001393082.1  transformer-2 protein homolog alpha isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC158667

  39. NM_001406154.1 → NP_001393083.1  transformer-2 protein homolog alpha isoform 34

    Status: VALIDATED

    Source sequence(s)
    AC158667

  40. NM_001406155.1 → NP_001393084.1  transformer-2 protein homolog alpha isoform 34

    Status: VALIDATED

    Source sequence(s)
    AC158667

  41. NM_001406156.1 → NP_001393085.1  transformer-2 protein homolog alpha isoform 34

    Status: VALIDATED

    Source sequence(s)
    AC158667

  42. NM_001406157.1 → NP_001393086.1  transformer-2 protein homolog alpha isoform 34

    Status: VALIDATED

    Source sequence(s)
    AC158667

  43. NM_001406158.1 → NP_001393087.1  transformer-2 protein homolog alpha isoform 36

    Status: VALIDATED

    Source sequence(s)
    AC158667

  44. NM_001406159.1 → NP_001393088.1  transformer-2 protein homolog alpha isoform 37

    Status: VALIDATED

    Source sequence(s)
    AC158667

  45. NM_001406160.1 → NP_001393089.1  transformer-2 protein homolog alpha isoform 37

    Status: VALIDATED

    Source sequence(s)
    AC158667

  46. NM_001406161.1 → NP_001393090.1  transformer-2 protein homolog alpha isoform 37

    Status: VALIDATED

    Source sequence(s)
    AC158667

  47. NM_198102.3 → NP_932770.2  transformer-2 protein homolog alpha isoform 1

    See identical proteins and their annotated locations for NP_932770.2

    Status: VALIDATED

    Source sequence(s)
    AC158667
    Consensus CDS
    CCDS39486.1
    UniProtKB/Swiss-Prot
    Q6PFR5
    UniProtKB/TrEMBL
    E9QP00
    Related
    ENSMUSP00000031841.8, ENSMUST00000031841.9
    Conserved Domains (1) summary
    cd12363
    Location:116 → 195
    RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    49220855..49241182 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505243.1 → XP_006505306.1  transformer-2 protein homolog alpha isoform X4

    UniProtKB/Swiss-Prot
    Q6PFR5
    Conserved Domains (1) summary
    cd12363
    Location:145 → 222
    RRM_TRA2; RNA recognition motif in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

  2. XM_036165704.1 → XP_036021597.1  transformer-2 protein homolog alpha isoform X7

    Conserved Domains (1) summary
    cd12363
    Location:17 → 96
    RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PFR5.1 GenPept UniProtKB/Swiss-Prot:Q6PFR5

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