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Hepacam2 HEPACAM family member 2 [ Mus musculus (house mouse) ]

Gene ID: 101202, updated on 5-Mar-2024

Summary

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Official Symbol
Hepacam2provided by MGI
Official Full Name
HEPACAM family member 2provided by MGI
Primary source
MGI:MGI:2141520
See related
Ensembl:ENSMUSG00000044156 AllianceGenome:MGI:2141520
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be involved in centrosome cycle. Predicted to act upstream of or within cell division. Predicted to be located in mitotic spindle and nucleoplasm. Predicted to be active in Golgi apparatus; microtubule cytoskeleton; and midbody. Is expressed in brain and foregut-midgut junction. Orthologous to human HEPACAM2 (HEPACAM family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 18.5), large intestine adult (RPKM 13.0) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Hepacam2 in Genome Data Viewer
Location:
6 A1; 6 1.8 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (3457202..3498319, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (3457089..3498322, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14986 Neighboring gene STARR-positive B cell enhancer ABC_E9269 Neighboring gene predicted gene, 20559 Neighboring gene STARR-seq mESC enhancer starr_14987 Neighboring gene STARR-seq mESC enhancer starr_14988 Neighboring gene STARR-seq mESC enhancer starr_14989 Neighboring gene STARR-positive B cell enhancer mm9_chr6:3349393-3349694 Neighboring gene sterile alpha motif domain containing 9-like Neighboring gene STARR-seq mESC enhancer starr_14990 Neighboring gene STARR-seq mESC enhancer starr_14991 Neighboring gene STARR-positive B cell enhancer ABC_E6412 Neighboring gene STARR-positive B cell enhancer ABC_E9270 Neighboring gene VPS50 EARP/GARPII complex subunit Neighboring gene STARR-seq mESC enhancer starr_14997 Neighboring gene predicted gene, 52885 Neighboring gene STARR-seq mESC enhancer starr_14998 Neighboring gene STARR-seq mESC enhancer starr_14999 Neighboring gene STARR-seq mESC enhancer starr_15001 Neighboring gene STARR-seq mESC enhancer starr_15002 Neighboring gene predicted gene, 53306

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Pancreatic islet and progenitor cell surface markers with cell sorting potential. Hald J, et al. Diabetologia, 2012 Jan. PMID 21947380
  2. Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. Gu Z, et al. PLoS One, 2015. PMID 25826454, Free PMC Article
  3. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
  4. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in centrosome cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in centrosome cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in midbody IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
HEPACAM family member 2
Names
mitotic kinetics regulator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411485.1 → NP_001398414.1  HEPACAM family member 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC022453, AC027655

  2. NM_178899.6 → NP_849230.1  HEPACAM family member 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_849230.1

    Status: VALIDATED

    Source sequence(s)
    AC022453
    Consensus CDS
    CCDS39414.1
    UniProtKB/Swiss-Prot
    Q4VAH7
    Related
    ENSMUSP00000058882.8, ENSMUST00000049985.15
    Conserved Domains (3) summary
    PHA02826
    Location:184 → 322
    PHA02826; IL-1 receptor-like protein; Provisional
    cd00096
    Location:167 → 233
    Ig; Immunoglobulin domain
    cl11960
    Location:36 → 143
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    3457202..3498319 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504960.3 → XP_006505023.1  HEPACAM family member 2 isoform X6

    See identical proteins and their annotated locations for XP_006505023.1

    Conserved Domains (3) summary
    PHA02826
    Location:108 → 246
    PHA02826; IL-1 receptor-like protein; Provisional
    cd00096
    Location:91 → 157
    Ig; Immunoglobulin domain
    cl11960
    Location:30 → 99
    Ig; Immunoglobulin domain

  2. XM_030255044.2 → XP_030110904.1  HEPACAM family member 2 isoform X6

    Conserved Domains (3) summary
    PHA02826
    Location:108 → 246
    PHA02826; IL-1 receptor-like protein; Provisional
    cd00096
    Location:91 → 157
    Ig; Immunoglobulin domain
    cl11960
    Location:30 → 99
    Ig; Immunoglobulin domain

  3. XM_006504958.3 → XP_006505021.1  HEPACAM family member 2 isoform X4

    Conserved Domains (3) summary
    PHA02826
    Location:183 → 321
    PHA02826; IL-1 receptor-like protein; Provisional
    cd00096
    Location:166 → 232
    Ig; Immunoglobulin domain
    cl11960
    Location:35 → 142
    Ig; Immunoglobulin domain

  4. XM_006504957.3 → XP_006505020.1  HEPACAM family member 2 isoform X1

    Related
    ENSMUST00000201276.2
    Conserved Domains (2) summary
    cd00096
    Location:168 → 234
    Ig; Immunoglobulin domain
    cl11960
    Location:37 → 144
    Ig; Immunoglobulin domain

  5. XM_030255043.1 → XP_030110903.1  HEPACAM family member 2 isoform X5

    Conserved Domains (3) summary
    PHA02826
    Location:183 → 321
    PHA02826; IL-1 receptor-like protein; Provisional
    cd00096
    Location:166 → 232
    Ig; Immunoglobulin domain
    cl11960
    Location:35 → 142
    Ig; Immunoglobulin domain

  6. XM_030255042.1 → XP_030110902.1  HEPACAM family member 2 isoform X3

    UniProtKB/Swiss-Prot
    Q4VAH7
    Conserved Domains (3) summary
    PHA02826
    Location:184 → 322
    PHA02826; IL-1 receptor-like protein; Provisional
    cd00096
    Location:167 → 233
    Ig; Immunoglobulin domain
    cl11960
    Location:36 → 143
    Ig; Immunoglobulin domain

  7. XM_030255041.1 → XP_030110901.1  HEPACAM family member 2 isoform X2

    Conserved Domains (2) summary
    cd00096
    Location:168 → 234
    Ig; Immunoglobulin domain
    cl11960
    Location:37 → 144
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4VAH7.1 GenPept UniProtKB/Swiss-Prot:Q4VAH7

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