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Itfg2 integrin alpha FG-GAP repeat containing 2 [ Mus musculus (house mouse) ]

Gene ID: 101142, updated on 5-Mar-2024

Summary

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Official Symbol
Itfg2provided by MGI
Official Full Name
integrin alpha FG-GAP repeat containing 2provided by MGI
Primary source
MGI:MGI:1915450
See related
Ensembl:ENSMUSG00000001518 AllianceGenome:MGI:1915450
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2700050P07Rik
Summary
Acts upstream of or within germinal center B cell differentiation. Located in cytosol and nucleoplasm. Orthologous to human ITFG2 (integrin alpha FG-GAP repeat containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 9.9), limb E14.5 (RPKM 8.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 F3; 6 62.99 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (128386407..128401873, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (128409047..128424927, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RAD9-HUS1-RAD1 interacting nuclear orphan 1 Neighboring gene forkhead box M1 Neighboring gene STARR-positive B cell enhancer ABC_E8833 Neighboring gene testis expressed 52 Neighboring gene STARR-positive B cell enhancer ABC_E4868 Neighboring gene nuclear receptor interacting protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E4869 Neighboring gene FK506 binding protein 4 Neighboring gene predicted gene 10069 Neighboring gene STAM binding protein, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Integrin-α FG-GAP repeat-containing protein 2 is critical for normal B cell differentiation and controls disease development in a lupus model. Al-Shami A, et al. J Immunol, 2013 Oct 1. PMID 23997217
  2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results identify Itfg2 as a novel contributor to B cell differentiation and a negative regulator of the autoimmune response during lupus.
    Title: Integrin-α FG-GAP repeat-containing protein 2 is critical for normal B cell differentiation and controls disease development in a lupus model.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cellular response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within germinal center B cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
part_of KICSTOR complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of KICSTOR complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
KICSTOR complex protein ITFG2
Names
integrin-alpha FG-GAP repeat-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133927.1 → NP_598688.1  KICSTOR complex protein ITFG2

    See identical proteins and their annotated locations for NP_598688.1

    Status: PROVISIONAL

    Source sequence(s)
    BC014833
    Consensus CDS
    CCDS20572.1
    UniProtKB/Swiss-Prot
    Q3UYJ5, Q8R148, Q91WI7
    Related
    ENSMUSP00000001559.9, ENSMUST00000001559.11
    Conserved Domains (2) summary
    pfam15907
    Location:49 → 382
    Itfg2; Integrin-alpha FG-GAP repeat-containing protein 2
    cl24051
    Location:22 → 53
    BBS2_Mid; Ciliary BBSome complex subunit 2, middle region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    128386407..128401873 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91WI7.1 GenPept UniProtKB/Swiss-Prot:Q91WI7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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