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Snx21 sorting nexin family member 21 [ Mus musculus (house mouse) ]

Gene ID: 101113, updated on 5-Mar-2024

Summary

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Official Symbol
Snx21provided by MGI
Official Full Name
sorting nexin family member 21provided by MGI
Primary source
MGI:MGI:1917729
See related
Ensembl:ENSMUSG00000050373 AllianceGenome:MGI:1917729
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5730407K14Rik
Summary
Enables phosphatidylinositol-3-phosphate binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in protein transport. Located in early endosome membrane. Is expressed in testis. Orthologous to human SNX21 (sorting nexin family member 21). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 51.8), ovary adult (RPKM 18.5) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H3; 2 85.27 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164627535..164635730)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164785759..164793810)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2C Neighboring gene troponin C2, fast Neighboring gene acyl-CoA thioesterase 8 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:164630130-164630494 Neighboring gene zinc finger SWIM-type containing 3 Neighboring gene STARR-seq mESC enhancer starr_06336 Neighboring gene zinc finger SWIM-type containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structure and Membrane Binding Properties of the Endosomal Tetratricopeptide Repeat (TPR) Domain-containing Sorting Nexins SNX20 and SNX21. Clairfeuille T, et al. J Biol Chem, 2015 Jun 5. PMID 25882846, Free PMC Article
  2. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538
  3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3-phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in early endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sorting nexin-21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399716.1 → NP_001386645.1  sorting nexin-21 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL591127
    UniProtKB/TrEMBL
    Q149Q9

  2. NM_133924.4 → NP_598685.2  sorting nexin-21 isoform 1

    See identical proteins and their annotated locations for NP_598685.2

    Status: VALIDATED

    Source sequence(s)
    AL591127
    Consensus CDS
    CCDS38328.1
    UniProtKB/Swiss-Prot
    Q3UR97
    Related
    ENSMUSP00000054137.7, ENSMUST00000056181.7
    Conserved Domains (3) summary
    sd00006
    Location:234 → 258
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:237 → 302
    TPR_12; Tetratricopeptide repeat
    cl02563
    Location:121 → 232
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    164627535..164635730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246444.2 → XP_030102304.1  sorting nexin-21 isoform X1

    Conserved Domains (3) summary
    sd00006
    Location:243 → 267
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:243 → 312
    TPR_12; Tetratricopeptide repeat
    cl02563
    Location:121 → 241
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  2. XM_006498528.5 → XP_006498591.1  sorting nexin-21 isoform X2

    Conserved Domains (3) summary
    sd00006
    Location:237 → 261
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:237 → 306
    TPR_12; Tetratricopeptide repeat
    cl02563
    Location:121 → 235
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  3. XM_006498530.5 → XP_006498593.1  sorting nexin-21 isoform X4

    See identical proteins and their annotated locations for XP_006498593.1

    UniProtKB/TrEMBL
    Q149Q9
    Conserved Domains (2) summary
    pfam13424
    Location:89 → 158
    TPR_12; Tetratricopeptide repeat
    cl02563
    Location:1 → 87
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  4. XM_006498529.5 → XP_006498592.1  sorting nexin-21 isoform X3

    Conserved Domains (2) summary
    pfam13424
    Location:107 → 176
    TPR_12; Tetratricopeptide repeat
    cl02563
    Location:7 → 105
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  5. XM_006498533.5 → XP_006498596.1  sorting nexin-21 isoform X4

    See identical proteins and their annotated locations for XP_006498596.1

    UniProtKB/TrEMBL
    Q149Q9
    Conserved Domains (2) summary
    pfam13424
    Location:89 → 158
    TPR_12; Tetratricopeptide repeat
    cl02563
    Location:1 → 87
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  6. XM_030246455.1 → XP_030102315.1  sorting nexin-21 isoform X4

    UniProtKB/TrEMBL
    Q149Q9
    Conserved Domains (2) summary
    pfam13424
    Location:89 → 158
    TPR_12; Tetratricopeptide repeat
    cl02563
    Location:1 → 87
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  7. XM_006498532.2 → XP_006498595.1  sorting nexin-21 isoform X4

    See identical proteins and their annotated locations for XP_006498595.1

    UniProtKB/TrEMBL
    Q149Q9
    Conserved Domains (2) summary
    pfam13424
    Location:89 → 158
    TPR_12; Tetratricopeptide repeat
    cl02563
    Location:1 → 87
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

RNA

  1. XR_003949535.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UR97.1 GenPept UniProtKB/Swiss-Prot:Q3UR97

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