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HELLPAR HELLP associated long non-coding RNA [ Homo sapiens (human) ]

Gene ID: 101101692, updated on 28-Aug-2022

Summary

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Official Symbol
HELLPARprovided by HGNC
Official Full Name
HELLP associated long non-coding RNAprovided by HGNC
Primary source
HGNC:HGNC:43984
See related
MIM:614985; AllianceGenome:HGNC:43984
Gene type
ncRNA
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
lncHELLP; LINC-HELLP
Annotation information
not in current annotation release
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Genomic context

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Location:
12q23.2

Bibliography

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Related articles in PubMed

  1. Mutations within the LINC-HELLP non-coding RNA differentially bind ribosomal and RNA splicing complexes and negatively affect trophoblast differentiation. van Dijk M, et al. Hum Mol Genet, 2015 Oct 1. PMID 26173455
  2. HELLP babies link a novel lincRNA to the trophoblast cell cycle. van Dijk M, et al. J Clin Invest, 2012 Nov. PMID 23093777, Free PMC Article
  3. Anticancer function of microRNA-30e is mediated by negative regulation of HELLPAR, a noncoding macroRNA, and genes involved in ubiquitination and cell cycle progression in prostate cancer. Ganapathy K, et al. Mol Oncol, 2022 Aug. PMID 35612714, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Anticancer function of microRNA-30e is mediated by negative regulation of HELLPAR, a noncoding macroRNA, and genes involved in ubiquitination and cell cycle progression in prostate cancer.
    Title: Anticancer function of microRNA-30e is mediated by negative regulation of HELLPAR, a noncoding macroRNA, and genes involved in ubiquitination and cell cycle progression in prostate cancer.
  2. Data show that LINC-HELLP transcript levels are significantly upregulated in plasma of women in their first trimester of pregnancy but not in patients later developing pregnancy complications, indicative of its functional significance in vivo.
    Title: Mutations within the LINC-HELLP non-coding RNA differentially bind ribosomal and RNA splicing complexes and negatively affect trophoblast differentiation.
Submit: New GeneRIF Correction

General gene information

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Other Names

  • long intergenic non-protein coding RNA associated with HELLP syndrome
Nucleotide Protein
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