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Ttll3 tubulin tyrosine ligase-like family, member 3 [ Mus musculus (house mouse) ]

Gene ID: 101100, updated on 5-Mar-2024

Summary

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Official Symbol
Ttll3provided by MGI
Official Full Name
tubulin tyrosine ligase-like family, member 3provided by MGI
Primary source
MGI:MGI:2141418
See related
Ensembl:ENSMUSG00000030276 AllianceGenome:MGI:2141418
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4833441J24Rik
Summary
Enables protein-glycine ligase activity, initiating. Involved in flagellated sperm motility and protein polyglycylation. Acts upstream of or within cilium assembly. Located in axoneme; microtubule cytoskeleton; and sperm flagellum. Is expressed in midbrain ventricular layer and pons ventricular layer. Orthologous to human TTLL3 (tubulin tyrosine ligase like 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 32.1), thymus adult (RPKM 12.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 E3; 6 52.76 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (113366221..113391553)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (113389260..113414592)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene chaperonin containing Tcp1, subunit 3 (gamma) pseudogene Neighboring gene transcriptional adaptor 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:113327864-113328099 Neighboring gene actin related protein 2/3 complex, subunit 4 Neighboring gene STARR-positive B cell enhancer ABC_E1706 Neighboring gene RNA pseudouridylate synthase domain containing 3 Neighboring gene cell death-inducing DFFA-like effector c Neighboring gene predicted gene, 52871

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility. Gadadhar S, et al. Science, 2021 Jan 8. PMID 33414192, Free PMC Article
  2. Alterations in the balance of tubulin glycylation and glutamylation in photoreceptors leads to retinal degeneration. Bosch Grau M, et al. J Cell Sci, 2017 Mar 1. PMID 28104815
  3. Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon. Rocha C, et al. EMBO J, 2014 Oct 1. PMID 25180231, Free PMC Article
  4. Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia. Bosch Grau M, et al. J Cell Biol, 2013 Aug 5. PMID 23897886, Free PMC Article
  5. Asialoglycoprotein Receptor 1 Functions as a Tumor Suppressor in Liver Cancer via Inhibition of STAT3. Zhu X, et al. Cancer Res, 2022 Nov 2. PMID 36043912

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility.
    Title: Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility.
  2. Decreased levels of TTLL3 expression are linked to the development of colorectal carcinomas.
    Title: Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon.
  3. The TTLL3 was required for stability and maintenance of ependymal cilia, whereas the polyglutamylase TTLL6 was necessary for coordinated beating behavior.
    Title: Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (7)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-glycine ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-glycine ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-glycine ligase activity, initiating IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-glycine ligase activity, initiating IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-glycine ligase activity, initiating IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cilium assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cilium movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein polyglycylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein polyglycylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axoneme IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tubulin monoglycylase TTLL3
Names
TTL domain protein
tubulin--tyrosine ligase-like protein 3
NP_001136204.1
NP_598684.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142732.1 → NP_001136204.1  tubulin monoglycylase TTLL3 isoform 2

    See identical proteins and their annotated locations for NP_001136204.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant has an alternate 5' exon and lacks multiple 3' exons but has an alternate 3' end sequence, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus and a shorter and different C-terminus, as compared to isoform 1.
    Source sequence(s)
    AK029462, AM690746, CF916454
    Consensus CDS
    CCDS85118.1
    UniProtKB/Swiss-Prot
    A4Q9E5
    Related
    ENSMUSP00000145049.2, ENSMUST00000204026.3

  2. NM_133923.7 → NP_598684.4  tubulin monoglycylase TTLL3 isoform 1

    See identical proteins and their annotated locations for NP_598684.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AA285487, AC153910, AK080321, AM690746
    Consensus CDS
    CCDS39593.2
    UniProtKB/Swiss-Prot
    A4Q9E5, Q8BV51, Q8C0Y7, Q8VDS2
    UniProtKB/TrEMBL
    H7BX03
    Related
    ENSMUSP00000032414.5, ENSMUST00000032414.11
    Conserved Domains (1) summary
    pfam03133
    Location:423 → 698
    TTL; Tubulin-tyrosine ligase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    113366221..113391553
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4Q9E5.1 GenPept UniProtKB/Swiss-Prot:A4Q9E5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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