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TRIM10 tripartite motif containing 10 [ Homo sapiens (human) ]

Gene ID: 10107, updated on 3-Apr-2024

Summary

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Official Symbol
TRIM10provided by HGNC
Official Full Name
tripartite motif containing 10provided by HGNC
Primary source
HGNC:HGNC:10072
See related
Ensembl:ENSG00000204613 MIM:605701; AllianceGenome:HGNC:10072
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF9; HERF1; RFB30
Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic bodies. Studies in mice suggest that this protein plays a role in terminal differentiation of erythroid cells. Alternate splicing of this gene generates two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Biased expression in bone marrow (RPKM 6.5), kidney (RPKM 1.8) and 6 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
6p22.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (30151943..30164009, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (30016218..30028317, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30119720..30128988, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene tripartite motif containing 40 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:30139523-30140072 Neighboring gene tripartite motif containing 15 Neighboring gene MPRA-validated peak5749 silencer Neighboring gene PAIP1 pseudogene 1 Neighboring gene tripartite motif containing 26 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:30168993-30169678 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:30169679-30170363 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:30175183-30176130 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:30181514-30182402 Neighboring gene tripartite motif containing 26B, pseudogene Neighboring gene HLA complex group 17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Oncogenic gene TRIM10 confers resistance to cisplatin in osteosarcoma cells and activates the NF-κB signaling pathway. Xi X, et al. Cell Biol Int, 2021 Jan. PMID 32997424
  2. Cloning, structural analysis, and mapping of the B30 and B7 multigenic families to the major histocompatibility complex (MHC) and other chromosomal regions. Henry J, et al. Immunogenetics, 1997. PMID 9271628
  3. Isolation of novel non-HLA gene fragments from the hemochromatosis region (6p21.3) by cDNA hybridization selection. Goei VL, et al. Am J Hum Genet, 1994 Feb. PMID 8304341, Free PMC Article
  4. TRIM10 binds to IFN-α/β receptor 1 to negatively regulate type I IFN signal transduction. Guo M, et al. Eur J Immunol, 2021 Jul. PMID 33811647
  5. Molecular cloning of testis-abundant finger Protein/Ring finger protein 23 (RNF23), a novel RING-B box-coiled coil-B30.2 protein on the class I region of the human MHC. Orimo A, et al. Biochem Biophys Res Commun, 2000 Sep 16. PMID 11006080

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRIM10 binds to IFN-alpha/beta receptor 1 to negatively regulate type I IFN signal transduction.
    Title: TRIM10 binds to IFN-α/β receptor 1 to negatively regulate type I IFN signal transduction.
  2. Oncogenic gene TRIM10 confers resistance to cisplatin in osteosarcoma cells and activates the NF-kappaB signaling pathway.
    Title: Oncogenic gene TRIM10 confers resistance to cisplatin in osteosarcoma cells and activates the NF-κB signaling pathway.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common genetic variation and the control of HIV-1 in humans.
EBI GWAS Catalog
Genome-wide association study of proneness to anger.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC141979

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of viral entry into host cell IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
tripartite motif-containing protein 10
Names
B30-RING finger protein
Zn-finger protein
hematopoietic RING finger 1
ring finger protein 9
tripartite motif protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006778.4 → NP_006769.2  tripartite motif-containing protein 10 isoform 1

    See identical proteins and their annotated locations for NP_006769.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1, which has a distinct C-terminus and is 86 aa longer than isoform 2.
    Source sequence(s)
    AL360163, AL669914, BC093926
    Consensus CDS
    CCDS34375.1
    UniProtKB/Swiss-Prot
    A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6
    Related
    ENSP00000397073.2, ENST00000449742.7
    Conserved Domains (4) summary
    smart00336
    Location:94 → 135
    BBOX; B-Box-type zinc finger
    cd15827
    Location:309 → 480
    SPRY_PRY_TRIM10; PRY/SPRY domain of tripartite motif-binding protein 10 (TRIM10) also known as hematopoietic RING finger 1 (HERF1)
    cl17238
    Location:16 → 60
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl23765
    Location:143 → 217
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  2. NM_052828.3 → NP_439893.2  tripartite motif-containing protein 10 isoform 2

    See identical proteins and their annotated locations for NP_439893.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site that results in the introduction of a 539 nt intron between a 3' penultimate and 3' terminal exon, compared to the 3' terminal exon of variant 1. This results in a frameshift and introduction of a novel stop codon. Isoform 2 has a distinct C-terminus and is 86 aa shorter than isoform 1.
    Source sequence(s)
    AL360163, AL669914, BC093926
    Consensus CDS
    CCDS4676.1
    UniProtKB/TrEMBL
    A0A1U9X8M5, A0A1U9X8N7
    Related
    ENSP00000365894.3, ENST00000376704.3
    Conserved Domains (4) summary
    smart00336
    Location:94 → 135
    BBOX; B-Box-type zinc finger
    cd16593
    Location:13 → 61
    RING-HC_TRIM10_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 10 (TRIM10) and similar proteins
    cl02614
    Location:309 → 368
    SPRY; SPRY domain
    cl25407
    Location:143 → 217
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    30151943..30164009 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418051.1 → XP_047274007.1  tripartite motif-containing protein 10 isoform X1

  2. XM_047418052.1 → XP_047274008.1  tripartite motif-containing protein 10 isoform X1

  3. XM_011514221.2 → XP_011512523.1  tripartite motif-containing protein 10 isoform X1

    See identical proteins and their annotated locations for XP_011512523.1

    Conserved Domains (4) summary
    smart00336
    Location:112 → 153
    BBOX; B-Box-type zinc finger
    cd15827
    Location:327 → 498
    SPRY_PRY_TRIM10; PRY/SPRY domain of tripartite motif-binding protein 10 (TRIM10) also known as hematopoietic RING finger 1 (HERF1)
    cl17238
    Location:41 → 78
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl23765
    Location:161 → 235
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  4. XM_011514223.3 → XP_011512525.1  tripartite motif-containing protein 10 isoform X1

    See identical proteins and their annotated locations for XP_011512525.1

    Conserved Domains (4) summary
    smart00336
    Location:112 → 153
    BBOX; B-Box-type zinc finger
    cd15827
    Location:327 → 498
    SPRY_PRY_TRIM10; PRY/SPRY domain of tripartite motif-binding protein 10 (TRIM10) also known as hematopoietic RING finger 1 (HERF1)
    cl17238
    Location:41 → 78
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl23765
    Location:161 → 235
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  5. XM_011514222.3 → XP_011512524.1  tripartite motif-containing protein 10 isoform X1

    See identical proteins and their annotated locations for XP_011512524.1

    Conserved Domains (4) summary
    smart00336
    Location:112 → 153
    BBOX; B-Box-type zinc finger
    cd15827
    Location:327 → 498
    SPRY_PRY_TRIM10; PRY/SPRY domain of tripartite motif-binding protein 10 (TRIM10) also known as hematopoietic RING finger 1 (HERF1)
    cl17238
    Location:41 → 78
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl23765
    Location:161 → 235
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  6. XM_047418053.1 → XP_047274009.1  tripartite motif-containing protein 10 isoform X2

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    1410039..1421508 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328439.1 → XP_054184414.1  tripartite motif-containing protein 10 isoform X3

    UniProtKB/Swiss-Prot
    A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6

  2. XM_054328440.1 → XP_054184415.1  tripartite motif-containing protein 10 isoform X3

    UniProtKB/Swiss-Prot
    A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6

  3. XM_054328441.1 → XP_054184416.1  tripartite motif-containing protein 10 isoform X2

  4. XM_054328442.1 → XP_054184417.1  tripartite motif-containing protein 10 isoform X4

    UniProtKB/TrEMBL
    A0A1U9X8M5

  5. XM_054328438.1 → XP_054184413.1  tripartite motif-containing protein 10 isoform X1

  6. XM_054328437.1 → XP_054184412.1  tripartite motif-containing protein 10 isoform X1

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    1631751..1643791 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329718.1 → XP_054185693.1  tripartite motif-containing protein 10 isoform X3

    UniProtKB/Swiss-Prot
    A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6

  2. XM_054329716.1 → XP_054185691.1  tripartite motif-containing protein 10 isoform X3

    UniProtKB/Swiss-Prot
    A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6

  3. XM_054329717.1 → XP_054185692.1  tripartite motif-containing protein 10 isoform X3

    UniProtKB/Swiss-Prot
    A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

    Range
    1407860..1419329 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330211.1 → XP_054186186.1  tripartite motif-containing protein 10 isoform X3

    UniProtKB/Swiss-Prot
    A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6

  2. XM_054330212.1 → XP_054186187.1  tripartite motif-containing protein 10 isoform X3

    UniProtKB/Swiss-Prot
    A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6

  3. XM_054330213.1 → XP_054186188.1  tripartite motif-containing protein 10 isoform X2

  4. XM_054330214.1 → XP_054186189.1  tripartite motif-containing protein 10 isoform X4

    UniProtKB/TrEMBL
    A0A1U9X8M5

  5. XM_054330210.1 → XP_054186185.1  tripartite motif-containing protein 10 isoform X1

  6. XM_054330209.1 → XP_054186184.1  tripartite motif-containing protein 10 isoform X1

Reference GRCh38.p14 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

    Range
    1462665..1474130 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330506.1 → XP_054186481.1  tripartite motif-containing protein 10 isoform X3

    UniProtKB/Swiss-Prot
    A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6

  2. XM_054330507.1 → XP_054186482.1  tripartite motif-containing protein 10 isoform X3

    UniProtKB/Swiss-Prot
    A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6

  3. XM_054330505.1 → XP_054186480.1  tripartite motif-containing protein 10 isoform X1

  4. XM_054330504.1 → XP_054186479.1  tripartite motif-containing protein 10 isoform X1

  5. XM_054330508.1 → XP_054186483.1  tripartite motif-containing protein 10 isoform X2

Reference GRCh38.p14 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

    Range
    1496018..1508131 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330755.1 → XP_054186730.1  tripartite motif-containing protein 10 isoform X1

  2. XM_054330756.1 → XP_054186731.1  tripartite motif-containing protein 10 isoform X3

    UniProtKB/Swiss-Prot
    A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6

  3. XM_054330754.1 → XP_054186729.1  tripartite motif-containing protein 10 isoform X1

  4. XM_054330757.1 → XP_054186732.1  tripartite motif-containing protein 10 isoform X2

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

    Range
    1407072..1418556 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330985.1 → XP_054186960.1  tripartite motif-containing protein 10 isoform X3

    UniProtKB/Swiss-Prot
    A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6

  2. XM_054330988.1 → XP_054186963.1  tripartite motif-containing protein 10 isoform X4

    UniProtKB/TrEMBL
    A0A1U9X8M5

  3. XM_054330986.1 → XP_054186961.1  tripartite motif-containing protein 10 isoform X3

    UniProtKB/Swiss-Prot
    A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6

  4. XM_054330987.1 → XP_054186962.1  tripartite motif-containing protein 10 isoform X2

Reference GRCh38.p14 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p14 ALT_REF_LOCI_7

    Range
    1450868..1462134 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331268.1 → XP_054187243.1  tripartite motif-containing protein 10 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    30016218..30028317 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054353995.1 → XP_054209970.1  tripartite motif-containing protein 10 isoform X1

  2. XM_054353996.1 → XP_054209971.1  tripartite motif-containing protein 10 isoform X3

    UniProtKB/Swiss-Prot
    A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6

  3. XM_054353997.1 → XP_054209972.1  tripartite motif-containing protein 10 isoform X3

    UniProtKB/Swiss-Prot
    A6NF84, Q5SRJ5, Q5SRK8, Q86Z08, Q96QB6, Q9C023, Q9C024, Q9UDY6

  4. XM_054353999.1 → XP_054209974.1  tripartite motif-containing protein 10 isoform X4

    UniProtKB/TrEMBL
    A0A1U9X8M5

  5. XM_054353994.1 → XP_054209969.1  tripartite motif-containing protein 10 isoform X1

  6. XM_054353993.1 → XP_054209968.1  tripartite motif-containing protein 10 isoform X1

  7. XM_054353998.1 → XP_054209973.1  tripartite motif-containing protein 10 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UDY6.3 GenPept UniProtKB/Swiss-Prot:Q9UDY6

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