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TCP11X2 t-complex 11 family, X-linked 2 [ Homo sapiens (human) ]

Gene ID: 100996648, updated on 8-Mar-2024

Summary

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Official Symbol
TCP11X2provided by HGNC
Official Full Name
t-complex 11 family, X-linked 2provided by HGNC
Primary source
HGNC:HGNC:48335
See related
Ensembl:ENSG00000215029 AllianceGenome:HGNC:48335
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be involved in protein kinase A signaling and regulation of sperm capacitation. Predicted to be active in acrosomal vesicle and sperm flagellum. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 1.7), lung (RPKM 0.3) and 2 other tissues See more
Orthologs
all
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Genomic context

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See TCP11X2 in Genome Data Viewer
Location:
Xq22.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (102460315..102471812, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (100904811..100916320, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (101715236..101726732, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 14 pseudogene Neighboring gene nuclear RNA export factor 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20918 Neighboring gene nuclear RNA export factor 2B Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:101726202-101726702 Neighboring gene thymosin beta 15A Neighboring gene forkhead box N3 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation. Jun L, et al. Curr Biol, 2001 Sep 18. PMID 11566096
  2. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Potential readthrough

Included gene: NXF2B

Homology

Clone Names

  • FLJ32823, FLJ35991, FLJ97841, DKFZp434B1612, DKFZp686N2036

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in protein kinase A signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of sperm capacitation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in acrosomal vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in sperm flagellum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
T-complex protein 11-like X-linked protein 2
Names
T-complex protein 11 X-linked protein 2
T-complex protein 11 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277423.2 → NP_001264352.1  T-complex protein 11-like X-linked protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001264352.1

    Status: VALIDATED

    Source sequence(s)
    AC235565
    Conserved Domains (1) summary
    pfam05794
    Location:1 → 388
    Tcp11; T-complex protein 11

  2. NM_001405027.1 → NP_001391956.1  T-complex protein 11-like X-linked protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC235565
    UniProtKB/Swiss-Prot
    A0A2R8YGI6, Q5H9J9
    Related
    ENSP00000496057.1, ENST00000642911.3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    102460315..102471812 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    100904811..100916320 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5H9J9.2 GenPept UniProtKB/Swiss-Prot:Q5H9J9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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