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Rab28 RAB28, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 100972, updated on 11-Apr-2024

Summary

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Official Symbol
Rab28provided by MGI
Official Full Name
RAB28, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:1917285
See related
Ensembl:ENSMUSG00000029128 AllianceGenome:MGI:1917285
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2700023P08Rik
Summary
Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Acts upstream of or within toxin transport. Predicted to be located in ciliary basal body and ciliary rootlet. Predicted to be active in endomembrane system. Is expressed in bone; digit mesenchyme; and naris. Used to study cone-rod dystrophy 18. Human ortholog(s) of this gene implicated in cone-rod dystrophy 18. Orthologous to human RAB28 (RAB28, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 18.3), testis adult (RPKM 14.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 B3; 5 22.58 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (41782316..41865535, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (41624973..41708193, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 4754 Neighboring gene STARR-seq mESC enhancer starr_12947 Neighboring gene predicted gene, 35380 Neighboring gene STARR-positive B cell enhancer mm9_chr5:42099330-42099630 Neighboring gene STARR-seq mESC enhancer starr_12949 Neighboring gene polymerase (RNA) III (DNA directed) polypeptide F pseudogene Neighboring gene predicted gene, 46910 Neighboring gene NK3 homeobox 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rab28 is a TBC1D1/TBC1D4 substrate involved in GLUT4 trafficking. Zhou Z, et al. FEBS Lett, 2017 Jan. PMID 27929607
  2. Role of the homeodomain transcription factor Bapx1 in mouse distal stomach development. Verzi MP, et al. Gastroenterology, 2009 May. PMID 19208343, Free PMC Article
  3. Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain. Licatalosi DD, et al. Genes Dev, 2012 Jul 15. PMID 22802532, Free PMC Article
  4. Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport. Fukuda M, et al. J Biol Chem, 2002 Apr 5. PMID 11856727
  5. Extensive molecular differences between anterior- and posterior-half-sclerotomes underlie somite polarity and spinal nerve segmentation. Hughes DS, et al. BMC Dev Biol, 2009 May 22. PMID 19463158, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these findings reveal that RAB28 is required for shedding and phagocytosis of cone OS discs.
    Title: The small GTPase RAB28 is required for phagocytosis of cone outer segments by the murine retinal pigmented epithelium.
  2. Rab28 is a substrate for the GAP domains of both TBC1D1 and TBC1D4 in vitro.
    Title: Rab28 is a TBC1D1/TBC1D4 substrate involved in GLUT4 trafficking.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (6) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC8039

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary rootlet ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ras-related protein Rab-28
NP_001297518.1
NP_001297519.1
NP_001297521.1
NP_081571.1
XP_006503714.1
XP_017176074.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310589.1 → NP_001297518.1  ras-related protein Rab-28 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR compared to variant 1. The encoded isoform (2) has a shorter, distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC102858, AC158920
    Consensus CDS
    CCDS80272.1
    UniProtKB/TrEMBL
    A0A0J9YV85
    Conserved Domains (1) summary
    cd04109
    Location:13 → 220
    Rab28; Rab GTPase family 28 (Rab28)

  2. NM_001310590.1 → NP_001297519.1  ras-related protein Rab-28 isoform 3

    See identical proteins and their annotated locations for NP_001297519.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate splice site in the 3' terminal exon and contains a distinct 3' coding region and 3' UTR compared to variant 1. The encoded isoform (3) has a shorter, distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC102858, AK012286, BY591132
    Consensus CDS
    CCDS80271.1
    UniProtKB/TrEMBL
    Q9CZQ8
    Related
    ENSMUSP00000144440.2, ENSMUST00000202913.2
    Conserved Domains (1) summary
    cl38936
    Location:13 → 193
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. NM_001310592.1 → NP_001297521.1  ras-related protein Rab-28 isoform 4

    See identical proteins and their annotated locations for NP_001297521.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start site compared to variant 1. The encoded isoform (4) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC102858, AK159493, AK161391, BY591132
    UniProtKB/TrEMBL
    Q3TTF7
    Conserved Domains (1) summary
    cl21455
    Location:1 → 144
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. NM_027295.3 → NP_081571.1  ras-related protein Rab-28 isoform 1

    See identical proteins and their annotated locations for NP_081571.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AC102858, AK159493, BB850234, BY591132
    Consensus CDS
    CCDS19258.1
    UniProtKB/Swiss-Prot
    Q99KL7
    UniProtKB/TrEMBL
    Q3TWY9
    Related
    ENSMUSP00000031011.9, ENSMUST00000031011.12
    Conserved Domains (2) summary
    smart00175
    Location:13 → 178
    RAB; Rab subfamily of small GTPases
    cd04109
    Location:13 → 221
    Rab28; Rab GTPase family 28 (Rab28)

RNA

  1. NR_132325.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an internal exon in the 5' region and uses an alternate splice site in the 3' terminal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC102858, AC158920

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    41782316..41865535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320585.3 → XP_017176074.1  ras-related protein Rab-28 isoform X1

    UniProtKB/TrEMBL
    A0A0J9YV85
    Related
    ENSMUSP00000144541.2, ENSMUST00000201422.4
    Conserved Domains (1) summary
    cd04109
    Location:13 → 220
    Rab28; Rab GTPase family 28 (Rab28)

  2. XM_006503651.5 → XP_006503714.1  ras-related protein Rab-28 isoform X2

    Conserved Domains (1) summary
    cd04109
    Location:16 → 213
    Rab28; Rab GTPase family 28 (Rab28)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99KL7.1 GenPept UniProtKB/Swiss-Prot:Q99KL7

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