LINC00365 long intergenic non-protein coding RNA 365 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LINC00365provided by HGNC
Official Full Name: long intergenic non-protein coding RNA 365provided by HGNC
Primary source: HGNC:HGNC:42687
See related: Ensembl:ENSG00000224511 AllianceGenome:HGNC:42687
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression: Biased expression in stomach (RPKM 4.6), gall bladder (RPKM 0.3) and 1 other tissue See more
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 13q12.3

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	13	NC_000013.11 (30103178..30108875, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	13	NC_060937.1 (29325703..29331400, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	13	NC_000013.10 (30677315..30683012, complement)

Chromosome 13 - NC_000013.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LINC00365 functions as a tumor suppressor by inhibiting HIF-1alpha-mediated glucose metabolism reprogramming in breast cancer.
Title: LINC00365 functions as a tumor suppressor by inhibiting HIF-1α-mediated glucose metabolism reprogramming in breast cancer.
LINC00365 promotes colorectal cancer cell progression through the Wnt/beta-catenin signaling pathway.
Title: LINC00365 promotes colorectal cancer cell progression through the Wnt/β-catenin signaling pathway.
A competing endogenous RNA network composed of 70 miRNAs, nine mRNAs, and LINC00365 was constructed. Eight of nine mRNAs were validated upregulated in The Cancer Genome Atlas data set. Our results suggested that LINC00365 was an oncogene in Colorectal cancer (CRC) and it could regulate the expression of several mRNAs through sponging miRNAs.
Title: Construction and analysis of dysregulated lncRNA-associated ceRNA network in colorectal cancer.

Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.