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Rubie RNA upstream of Bmp4 expressed in inner ear [ Mus musculus (house mouse) ]

Gene ID: 100873094, updated on 21-Apr-2024

Summary

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Official Symbol
Rubieprovided by MGI
Official Full Name
RNA upstream of Bmp4 expressed in inner earprovided by MGI
Primary source
MGI:MGI:5568573
See related
Ensembl:ENSMUSG00000085123 AllianceGenome:MGI:5568573
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1584; Gm15219
Summary
This gene represents a non-coding RNA. It is located upstream of the Bmp4 gene (GeneID:12159), and is involved in regulating Bmp4 expression in the inner ear. The gene mutation results in vestibular malformation in mice. [provided by RefSeq, Mar 2012]
Expression
Biased expression in testis adult (RPKM 1.2), CNS E11.5 (RPKM 0.2) and 8 other tissues See more
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Genomic context

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Location:
14 C1; 14 24.11 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (46805788..46813308, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (46568331..46575851, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34756 Neighboring gene RIKEN cDNA E130120K24 gene Neighboring gene RIKEN cDNA 4933425B07 gene Neighboring gene VISTA enhancer mm387 Neighboring gene ubiquitin family domain containing 1 pseudogene Neighboring gene predicted gene, 41146

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mutation of Rubie, a novel long non-coding RNA located upstream of Bmp4, causes vestibular malformation in mice. Roberts KA, et al. PLoS One, 2012. PMID 22253730, Free PMC Article
  2. Minimal in vivo requirements for developmentally regulated cardiac long intergenic non-coding RNAs. George MR, et al. Development, 2019 Dec 9. PMID 31784461, Free PMC Article
  3. Global discovery of erythroid long noncoding RNAs reveals novel regulators of red cell maturation. Alvarez-Dominguez JR, et al. Blood, 2014 Jan 23. PMID 24200680, Free PMC Article
  4. Widespread and dynamic translational control of red blood cell development. Alvarez-Dominguez JR, et al. Blood, 2017 Feb 2. PMID 27899360, Free PMC Article
  5. The Vertebrate Genome Annotation browser 10 years on. Harrow JL, et al. Nucleic Acids Res, 2014 Jan. PMID 24316575, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of equilibrioception IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within semicircular canal development IMP
Inferred from Mutant Phenotype
more info
 PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_046459.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC103579, CT009556
    Related
    ENSMUST00000151828.3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    46805788..46813308 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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