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MIR5194 microRNA 5194 [ Homo sapiens (human) ]

Gene ID: 100847051, updated on 10-Oct-2023

Summary

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Official Symbol
MIR5194provided by HGNC
Official Full Name
microRNA 5194provided by HGNC
Primary source
HGNC:HGNC:43498
See related
Ensembl:ENSG00000264653 miRBase:MI0018173; AllianceGenome:HGNC:43498
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
mir-5194
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

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Location:
8q24.21
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (130008334..130008453, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (131134811..131134930, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (131020580..131020699, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900265 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:130881998-130882552 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:130882553-130883105 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:130899091-130899604 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:130899605-130900116 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27971 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27972 Neighboring gene CYFIP related Rac1 interactor B Neighboring gene MPRA-validated peak7177 silencer Neighboring gene Sharpr-MPRA regulatory region 603 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19541 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27973 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:130957594-130958094 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:130971367-130971867 Neighboring gene MPRA-validated peak7178 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27974 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27975 Neighboring gene uncharacterized LOC124902025 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27976 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:131005193-131005693 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19542 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19543 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19544 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19545 Neighboring gene RNA, U7 small nuclear 181 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:131054337-131055152 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27979 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:131067248-131067450 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:131081877-131082759 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27980 Neighboring gene RNA, U6 small nuclear 1255, pseudogene Neighboring gene ASAP1 intronic transcript 2 Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. LINC01063 functions as an oncogene in melanoma through regulation of miR-5194-mediated SOX12 expression. Xu J, et al. Melanoma Res, 2022 Aug 1. PMID 35256570
  2. Discovery of new microRNAs by small RNAome deep sequencing in childhood acute lymphoblastic leukemia. Schotte D, et al. Leukemia, 2011 Sep. PMID 21606961
  3. miRBase: integrating microRNA annotation and deep-sequencing data. Kozomara A, et al. Nucleic Acids Res, 2011 Jan. PMID 21037258, Free PMC Article
  4. miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381832, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LINC01063 functions as an oncogene in melanoma through regulation of miR-5194-mediated SOX12 expression.
    Title: LINC01063 functions as an oncogene in melanoma through regulation of miR-5194-mediated SOX12 expression.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Other Names

  • hsa-mir-5194

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_049826.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AC131568
    Related
    ENST00000582634.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    130008334..130008453 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    131134811..131134930 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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