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MIR5680 microRNA 5680 [ Homo sapiens (human) ]

Gene ID: 100847001, updated on 10-Oct-2023

Summary

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Official Symbol
MIR5680provided by HGNC
Official Full Name
microRNA 5680provided by HGNC
Primary source
HGNC:HGNC:43492
See related
Ensembl:ENSG00000266756 miRBase:MI0019280; AllianceGenome:HGNC:43492
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

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Location:
8q22.3
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (102125432..102125515)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (103137660..103137743)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene neurocalcin delta Neighboring gene uncharacterized LOC104054148 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27740 Neighboring gene uncharacterized LOC124901997 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr8:103078318-103078896 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_100837 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27741 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27742 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27743 Neighboring gene NANOG hESC enhancer GRCh37_chr8:103124713-103125214 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19434 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19435 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:103144879-103145380 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:103145381-103145880 Neighboring gene ATP synthase subunit ATP5MJ, mitochondrial-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27744 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:103203063-103203680 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27745 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27746 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:103240735-103241235 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:103243938-103244157 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:103248510-103249709 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27747 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19436 Neighboring gene ribonucleotide reductase regulatory TP53 inducible subunit M2B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MicroRNAs associated with metastatic prostate cancer. Watahiki A, et al. PLoS One, 2011. PMID 21980368, Free PMC Article
  2. miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381832, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Other Names

  • hsa-mir-5680

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_049859.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AP001328
    Related
    ENST00000577577.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    102125432..102125515
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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