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Dcun1d4 defective in cullin neddylation 1 domain containing 4 [ Mus musculus (house mouse) ]

Gene ID: 100737, updated on 5-Mar-2024

Summary

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Official Symbol
Dcun1d4provided by MGI
Official Full Name
defective in cullin neddylation 1 domain containing 4provided by MGI
Primary source
MGI:MGI:2140972
See related
Ensembl:ENSMUSG00000051674 AllianceGenome:MGI:2140972
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DCNL4
Summary
Predicted to enable cullin family protein binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin-like protein binding activity. Predicted to be involved in positive regulation of protein neddylation; positive regulation of ubiquitin-protein transferase activity; and protein neddylation. Predicted to be located in nucleus. Predicted to be part of ubiquitin ligase complex. Is expressed in early conceptus; genitourinary system; nervous system; and neural retina. Orthologous to human DCUN1D4 (defective in cullin neddylation 1 domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 6.2), cortex adult (RPKM 5.5) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 C3.3; 5 38.85 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (73638353..73718137)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (73481010..73560794)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene cell wall biogenesis 43 C-terminal homolog Neighboring gene STARR-seq mESC enhancer starr_13387 Neighboring gene STARR-positive B cell enhancer ABC_E153 Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene leucine rich repeat containing 66 Neighboring gene sarcoglycan, beta (dystrophin-associated glycoprotein)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
  2. The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease. Willnow T, et al. Organogenesis, 2005 Apr. PMID 19521566, Free PMC Article
  3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  5. A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Thompson CL, et al. Neuron, 2014 Jul 16. PMID 24952961, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC117952

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cullin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cullin family protein binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-like protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of protein neddylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein neddylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DCN1-like protein 4
Names
DCN1, defective in cullin neddylation 1, domain containing 4
DCUN1 domain-containing protein 4
defective in cullin neddylation protein 1-like protein 4
squamous cell carcinoma-related oncogene 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190733.2 → NP_001177662.1  DCN1-like protein 4 isoform C

    See identical proteins and their annotated locations for NP_001177662.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (C) differs in the 5' UTR, lacks a portion of the 5' coding region and an in-frame exon in the 3' coding region, and initiates translation at an alternate start codon, compared to variant A. The encoded isoform (C) has a distinct N-terminus and is shorter than isoform A.
    Source sequence(s)
    AC134551, AC140429
    Consensus CDS
    CCDS57350.1
    UniProtKB/TrEMBL
    B7ZMU0
    Related
    ENSMUSP00000109187.2, ENSMUST00000113558.8
    Conserved Domains (1) summary
    pfam03556
    Location:175 → 251
    Cullin_binding; Cullin binding

  2. NM_001190734.2 → NP_001177663.1  DCN1-like protein 4 isoform A

    See identical proteins and their annotated locations for NP_001177663.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (A) encodes the longest isoform (A).
    Source sequence(s)
    AC134551, AC140429
    Consensus CDS
    CCDS57349.1
    UniProtKB/TrEMBL
    Q8C5X2
    Related
    ENSMUSP00000084427.6, ENSMUST00000087181.12
    Conserved Domains (1) summary
    pfam03556
    Location:189 → 300
    Cullin_binding; Cullin binding

  3. NM_001425798.1 → NP_001412727.1  DCN1-like protein 4 isoform D

    Status: VALIDATED

    Source sequence(s)
    AC134551, AC140429

  4. NM_001425799.1 → NP_001412728.1  DCN1-like protein 4 isoform E

    Status: VALIDATED

    Source sequence(s)
    AC134551, AC140429

  5. NM_001425800.1 → NP_001412729.1  DCN1-like protein 4 isoform E

    Status: VALIDATED

    Source sequence(s)
    AC134551, AC140429

  6. NM_178896.6 → NP_849227.1  DCN1-like protein 4 isoform B

    See identical proteins and their annotated locations for NP_849227.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (B) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant A. The encoded isoform (B) has a distinct N-terminus and is shorter than isoform A.
    Source sequence(s)
    AC134551, AC140429
    Consensus CDS
    CCDS19342.1
    UniProtKB/Swiss-Prot
    Q2YDW5, Q8CCA0
    Related
    ENSMUSP00000067616.6, ENSMUST00000063882.12
    Conserved Domains (1) summary
    pfam03556
    Location:175 → 286
    Cullin_binding; Cullin binding

RNA

  1. NR_153313.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (D) differs in the 5' end and lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC134551, AC140429

  2. NR_189590.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC134551, AC140429

  3. NR_189591.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC134551, AC140429

  4. NR_189592.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC134551, AC140429

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    73638353..73718137
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503631.3 → XP_006503694.1  DCN1-like protein 4 isoform X2

    See identical proteins and their annotated locations for XP_006503694.1

    Conserved Domains (1) summary
    pfam03556
    Location:115 → 225
    Cullin_binding; Cullin binding

  2. XM_030254025.1 → XP_030109885.1  DCN1-like protein 4 isoform X2

    Conserved Domains (1) summary
    pfam03556
    Location:115 → 225
    Cullin_binding; Cullin binding

  3. XM_006503636.4 → XP_006503699.1  DCN1-like protein 4 isoform X2

    See identical proteins and their annotated locations for XP_006503699.1

    Conserved Domains (1) summary
    pfam03556
    Location:115 → 225
    Cullin_binding; Cullin binding

  4. XM_017320580.3 → XP_017176069.1  DCN1-like protein 4 isoform X3

    Conserved Domains (1) summary
    pfam03556
    Location:94 → 204
    Cullin_binding; Cullin binding

  5. XM_036164695.1 → XP_036020588.1  DCN1-like protein 4 isoform X2

    Conserved Domains (1) summary
    pfam03556
    Location:115 → 225
    Cullin_binding; Cullin binding

  6. XM_006503628.5 → XP_006503691.1  DCN1-like protein 4 isoform X2

    See identical proteins and their annotated locations for XP_006503691.1

    Conserved Domains (1) summary
    pfam03556
    Location:115 → 225
    Cullin_binding; Cullin binding

  7. XM_006503630.5 → XP_006503693.1  DCN1-like protein 4 isoform X2

    See identical proteins and their annotated locations for XP_006503693.1

    Conserved Domains (1) summary
    pfam03556
    Location:115 → 225
    Cullin_binding; Cullin binding

  8. XM_036164694.1 → XP_036020587.1  DCN1-like protein 4 isoform X2

    Conserved Domains (1) summary
    pfam03556
    Location:115 → 225
    Cullin_binding; Cullin binding

  9. XM_006503637.5 → XP_006503700.1  DCN1-like protein 4 isoform X2

    See identical proteins and their annotated locations for XP_006503700.1

    Conserved Domains (1) summary
    pfam03556
    Location:115 → 225
    Cullin_binding; Cullin binding

RNA

  1. XR_376792.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CCA0.1 GenPept UniProtKB/Swiss-Prot:Q8CCA0

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