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Mapre3 microtubule-associated protein, RP/EB family, member 3 [ Mus musculus (house mouse) ]

Gene ID: 100732, updated on 5-Mar-2024

Summary

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Official Symbol
Mapre3provided by MGI
Official Full Name
microtubule-associated protein, RP/EB family, member 3provided by MGI
Primary source
MGI:MGI:2140967
See related
Ensembl:ENSMUSG00000029166 AllianceGenome:MGI:2140967
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EB2; EB3; RP3; EBF3
Summary
Enables microtubule plus-end binding activity. Involved in positive regulation of cyclin-dependent protein serine/threonine kinase activity and positive regulation of transcription, DNA-templated. Acts upstream of or within positive regulation of microtubule plus-end binding activity. Located in cytoplasm; microtubule plus-end; and midbody. Colocalizes with microtubule. Orthologous to human MAPRE3 (microtubule associated protein RP/EB family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 61.2), frontal lobe adult (RPKM 48.7) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Mapre3 in Genome Data Viewer
Location:
5 B1; 5 16.9 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (30972075..31023447)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (30814606..30866106)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene autophagy-related 3 pseudogene Neighboring gene dihydropyrimidinase-like 5 Neighboring gene STARR-seq mESC enhancer starr_12761 Neighboring gene predicted gene, 46907 Neighboring gene STARR-positive B cell enhancer ABC_E10311 Neighboring gene STARR-seq mESC enhancer starr_12763 Neighboring gene transmembrane protein 214 Neighboring gene nuclear encoded tRNA tyrosine 9 (anticodon GTA) Neighboring gene predicted gene, 35795 Neighboring gene ATP/GTP binding protein-like 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cytoskeleton Protein EB3 Contributes to Dendritic Spines Enlargement and Enhances Their Resilience to Toxic Effects of Beta-Amyloid. Pchitskaya E, et al. Int J Mol Sci, 2022 Feb 18. PMID 35216391, Free PMC Article
  2. Stim2-Eb3 Association and Morphology of Dendritic Spines in Hippocampal Neurons. Pchitskaya E, et al. Sci Rep, 2017 Dec 15. PMID 29247211, Free PMC Article
  3. EB3 regulates microtubule dynamics at the cell cortex and is required for myoblast elongation and fusion. Straube A, et al. Curr Biol, 2007 Aug 7. PMID 17658256, Free PMC Article
  4. Microtubule-Associated Protein EB3 Regulates IP3 Receptor Clustering and Ca(2+) Signaling in Endothelial Cells. Geyer M, et al. Cell Rep, 2015 Jul 7. PMID 26119739, Free PMC Article
  5. Tau regulates the localization and function of End-binding proteins 1 and 3 in developing neuronal cells. Sayas CL, et al. J Neurochem, 2015 Jun. PMID 25761518

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cytoskeleton Protein EB3 Contributes to Dendritic Spines Enlargement and Enhances Their Resilience to Toxic Effects of Beta-Amyloid.
    Title: Cytoskeleton Protein EB3 Contributes to Dendritic Spines Enlargement and Enhances Their Resilience to Toxic Effects of Beta-Amyloid.
  2. The authors propose that EB3 is involved in regulation of dendritic spines morphology, in part due to its association with STIM2, and that modulation of EB3 expression is a potential way to overcome synaptic loss during Alzheimer's disease.
    Title: Stim2-Eb3 Association and Morphology of Dendritic Spines in Hippocampal Neurons.
  3. EB3 binds to IP3 receptors, promotes IP3R clustering and Ca2+ signals in endothelial cells.
    Title: Microtubule-Associated Protein EB3 Regulates IP3 Receptor Clustering and Ca(2+) Signaling in Endothelial Cells.
  4. We describe here a novel function for tau as a direct regulator of End binding (EB) proteins in differentiating neuronal cells
    Title: Tau regulates the localization and function of End-binding proteins 1 and 3 in developing neuronal cells.
  5. MAP1B interacts directly with EB1 and EB3 (EBs), two core 'microtubule plus-end tracking proteins' ( TIPs), and sequesters them in the cytosol of developing neuronal cells.
    Title: MAP1B regulates microtubule dynamics by sequestering EB1/3 in the cytosol of developing neuronal cells.
  6. DDA3 is a novel microtubule-associated protein that binds to EB3, and results implicate DDA3 and EB3 in the beta-catenin-mediated growth signaling.
    Title: p53 downstream target DDA3 is a novel microtubule-associated protein that interacts with end-binding protein EB3 and activates beta-catenin pathway.
  7. Two +TIPs, CLIP-170 and end-binding protein 3 (EB3), turn over rapidly on MT ends. Diffusion of CLIP-170 and EB3 appears to be rate limiting for their binding to MT plus ends.
    Title: Dynamic behavior of GFP-CLIP-170 reveals fast protein turnover on microtubule plus ends.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule plus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule plus-end binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of microtubule plus-end binding IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of microtubule polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule plus-end IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule plus-end IDA
Inferred from Direct Assay
more info
 PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitotic spindle astral microtubule end ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
microtubule-associated protein RP/EB family member 3
Names
EB1 protein family member 3
end-binding protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310516.2 → NP_001297445.1  microtubule-associated protein RP/EB family member 3 isoform 2

    See identical proteins and their annotated locations for NP_001297445.1

    Status: VALIDATED

    Source sequence(s)
    AC109606, AC109611
    Consensus CDS
    CCDS80240.1
    UniProtKB/TrEMBL
    D3Z6G3
    Conserved Domains (1) summary
    COG5217
    Location:16 → 264
    BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]

  2. NM_001425743.1 → NP_001412672.1  microtubule-associated protein RP/EB family member 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC109606, AC109611
    UniProtKB/Swiss-Prot
    Q61167, Q6PER3
    UniProtKB/TrEMBL
    Q2UZW7

  3. NM_001425744.1 → NP_001412673.1  microtubule-associated protein RP/EB family member 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC109606, AC109611
    UniProtKB/TrEMBL
    D3Z6G3

  4. NM_133350.3 → NP_579928.1  microtubule-associated protein RP/EB family member 3 isoform 1

    See identical proteins and their annotated locations for NP_579928.1

    Status: VALIDATED

    Source sequence(s)
    AC109606, AC109611
    Consensus CDS
    CCDS19163.1
    UniProtKB/Swiss-Prot
    Q61167, Q6PER3
    UniProtKB/TrEMBL
    Q2UZW7
    Related
    ENSMUSP00000031058.9, ENSMUST00000031058.15
    Conserved Domains (1) summary
    COG5217
    Location:16 → 279
    BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]

RNA

  1. NR_189585.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC109606, AC109611

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    30972075..31023447
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254024.2 → XP_030109884.1  microtubule-associated protein RP/EB family member 3 isoform X2

    UniProtKB/TrEMBL
    D3Z6G3
    Conserved Domains (1) summary
    COG5217
    Location:16 → 264
    BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]

  2. XM_030254022.2 → XP_030109882.1  microtubule-associated protein RP/EB family member 3 isoform X1

    UniProtKB/Swiss-Prot
    Q61167, Q6PER3
    UniProtKB/TrEMBL
    Q2UZW7
    Conserved Domains (1) summary
    COG5217
    Location:16 → 279
    BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]

RNA

  1. XR_003955568.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PER3.1 GenPept UniProtKB/Swiss-Prot:Q6PER3

Gene LinkOut

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