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Tent2 terminal nucleotidyltransferase 2 [ Mus musculus (house mouse) ]

Gene ID: 100715, updated on 11-Apr-2024

Summary

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Official Symbol
Tent2provided by MGI
Official Full Name
terminal nucleotidyltransferase 2provided by MGI
Primary source
MGI:MGI:2140950
See related
Ensembl:ENSMUSG00000042167 AllianceGenome:MGI:2140950
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gld2; GLD-2; Papd4; 8030446C20Rik
Summary
Predicted to enable 5'-3' RNA polymerase activity and polynucleotide adenylyltransferase activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Located in nucleus. Is expressed in embryo. Orthologous to human TENT2 (terminal nucleotidyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 18.2), placenta adult (RPKM 16.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tent2 in Genome Data Viewer
Location:
13 C3; 13 47.81 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (93282363..93330662, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (93145855..93192435, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene cardiomyopathy associated 5 Neighboring gene RIKEN cDNA A630019I02 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:93864100-93864343 Neighboring gene predicted gene 4814 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:93864596-93864798 Neighboring gene STARR-seq mESC enhancer starr_35275 Neighboring gene STARR-seq mESC enhancer starr_35276 Neighboring gene STARR-seq mESC enhancer starr_35278 Neighboring gene predicted gene, 41020 Neighboring gene STARR-seq mESC enhancer starr_35279 Neighboring gene STARR-seq mESC enhancer starr_35280 Neighboring gene STARR-positive B cell enhancer mm9_chr13:94013261-94013562 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Gld2-catalyzed 3' monoadenylation of miRNAs in the hippocampus has no detectable effect on their stability or on animal behavior. Mansur F, et al. RNA, 2016 Oct. PMID 27495319, Free PMC Article
  2. Selective stabilization of mammalian microRNAs by 3' adenylation mediated by the cytoplasmic poly(A) polymerase GLD-2. Katoh T, et al. Genes Dev, 2009 Feb 15. PMID 19240131, Free PMC Article
  3. Possible role of mouse poly(A) polymerase mGLD-2 during oocyte maturation. Nakanishi T, et al. Dev Biol, 2006 Jan 1. PMID 16325797
  4. Noncanonical cytoplasmic poly(A) polymerases regulate RNA levels, alternative RNA processing, and synaptic plasticity but not hippocampal-dependent behaviours. Mansur F, et al. RNA Biol, 2021 Jul. PMID 32954964, Free PMC Article
  5. Musashi protein-directed translational activation of target mRNAs is mediated by the poly(A) polymerase, germ line development defective-2. Cragle C, et al. J Biol Chem, 2014 May 16. PMID 24644291, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Noncanonical cytoplasmic poly(A) polymerases regulate RNA levels, alternative RNA processing, and synaptic plasticity but not hippocampal-dependent behaviours.
    Title: Noncanonical cytoplasmic poly(A) polymerases regulate RNA levels, alternative RNA processing, and synaptic plasticity but not hippocampal-dependent behaviours.
  2. In Gld2 knockout mice there are detectable alterations in specific miRNA monoadenylation in the hippocampus, but no detectable effect on miRNA stability and no overt change in animal behavior.
    Title: Gld2-catalyzed 3' monoadenylation of miRNAs in the hippocampus has no detectable effect on their stability or on animal behavior.
  3. poly(A) polymerase Gld2, deadenylase PARN, and translation inhibitory factor neuroguidin (Ngd) are components of a dendritic CPEB-associated polyadenylation apparatus
    Title: Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex.
  4. We found an association of mGLD-2 with cytoplasmic polyadenylation components, CPEB and CPSF described in Xenopus oocytes
    Title: Disruption of mouse poly(A) polymerase mGLD-2 does not alter polyadenylation status in oocytes and somatic cells.
  5. mGLD-2 may act in the ooplasm on the progression of metaphase I to metaphase II during oocyte maturation.
    Title: Possible role of mouse poly(A) polymerase mGLD-2 during oocyte maturation.
  6. identified GLD-2, which is a regulatory cytoplasmic poly(A) polymerase, as responsible for the 3'-terminal adenylation of miR-122 after unwinding of the miR-122/miR-122* duplex
    Title: Selective stabilization of mammalian microRNAs by 3' adenylation mediated by the cytoplasmic poly(A) polymerase GLD-2.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A) RNA polymerase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA polyadenylation at postsynapse ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in histone mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of miRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in postsynaptic modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of translation at postsynapse ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in perforant pathway to dendrate granule cell synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
poly(A) RNA polymerase GLD2
Names
PAP associated domain containing 4
PAP-associated domain-containing protein 4
cytoplasmic poly(A) polymerase
NP_001348465.1
NP_001348466.1
NP_598666.1
XP_006517573.1
XP_030102937.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361536.1 → NP_001348465.1  poly(A) RNA polymerase GLD2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC120347, AC121991, AC130217
    Consensus CDS
    CCDS88498.1
    Related
    ENSMUSP00000153703.2, ENSMUST00000225868.2
    Conserved Domains (1) summary
    COG5260
    Location:121 → 464
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  2. NM_001361537.1 → NP_001348466.1  poly(A) RNA polymerase GLD2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC120347, AC121991, AC130217
    Consensus CDS
    CCDS26686.1
    UniProtKB/Swiss-Prot
    A4F5H0, Q8CCH5, Q91YI6
    Conserved Domains (1) summary
    COG5260
    Location:121 → 468
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  3. NM_133905.3 → NP_598666.1  poly(A) RNA polymerase GLD2 isoform 1

    See identical proteins and their annotated locations for NP_598666.1

    Status: VALIDATED

    Source sequence(s)
    AC120347, AC121991, AC130217
    Consensus CDS
    CCDS26686.1
    UniProtKB/Swiss-Prot
    A4F5H0, Q8CCH5, Q91YI6
    Related
    ENSMUSP00000048124.6, ENSMUST00000048702.7
    Conserved Domains (1) summary
    COG5260
    Location:121 → 468
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

RNA

  1. NR_154997.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC120347, AC121991, AC130217

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    93282363..93330662 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247077.2 → XP_030102937.1  poly(A) RNA polymerase GLD2 isoform X2

    Conserved Domains (1) summary
    COG5260
    Location:121 → 464
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  2. XM_006517510.5 → XP_006517573.1  poly(A) RNA polymerase GLD2 isoform X1

    See identical proteins and their annotated locations for XP_006517573.1

    UniProtKB/Swiss-Prot
    A4F5H0, Q8CCH5, Q91YI6
    Conserved Domains (1) summary
    COG5260
    Location:121 → 468
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

RNA

  1. XR_004937923.1 RNA Sequence

  2. XR_001780738.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91YI6.1 GenPept UniProtKB/Swiss-Prot:Q91YI6

Gene LinkOut

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