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Trrap transformation/transcription domain-associated protein [ Mus musculus (house mouse) ]

Gene ID: 100683, updated on 5-Mar-2024

Summary

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Official Symbol
Trrapprovided by MGI
Official Full Name
transformation/transcription domain-associated proteinprovided by MGI
Primary source
MGI:MGI:2153272
See related
Ensembl:ENSMUSG00000045482 AllianceGenome:MGI:2153272
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables transcription coactivator activity. Acts upstream of or within regulation of transcription, DNA-templated. Part of transcription regulator complex. Is expressed in several structures, including cranial ganglion; submandibular gland primordium; testis; tooth; and vibrissa. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 75. Orthologous to human TRRAP (transformation/transcription domain associated protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 24.1), thymus adult (RPKM 17.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Trrap in Genome Data Viewer
Location:
5 G2; 5 84.77 cM
Exon count:
75
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (144704547..144796588)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (144767737..144859778)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 130 Neighboring gene STARR-seq mESC enhancer starr_14819 Neighboring gene predicted gene, 38739 Neighboring gene predicted gene, 23995 Neighboring gene SMAD specific E3 ubiquitin protein ligase 1 Neighboring gene microRNA 7039 Neighboring gene predicted gene, 33821

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of histone acetyltransferase cofactor transformation/transcription domain-associated protein impairs liver regeneration after toxic injury. Shukla V, et al. Hepatology, 2011 Mar. PMID 21319192
  2. Histone acetyltransferase cofactor Trrap is essential for maintaining the hematopoietic stem/progenitor cell pool. Loizou JI, et al. J Immunol, 2009 Nov 15. PMID 19880447
  3. Genome-wide analysis of gene expression regulated by the HAT cofactor Trrap in conditional knockout cells. Herceg Z, et al. Nucleic Acids Res, 2003 Dec 1. PMID 14627834, Free PMC Article
  4. HAT cofactor TRRAP modulates microtubule dynamics via SP1 signaling to prevent neurodegeneration. Tapias A, et al. Elife, 2021 Feb 17. PMID 33594975, Free PMC Article
  5. Tissue-specific inactivation of HAT cofactor TRRAP reveals its essential role in B cells. Leduc C, et al. Cell Cycle, 2014. PMID 24675885, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRRAP deficiency impairs B-cell development but does not directly affect class switch recombination (CSR. Instead, cells induced to proliferate undergo apoptosis. Our findings demonstrate a central and general role of TRRAP in cell proliferation.
    Title: Tissue-specific inactivation of HAT cofactor TRRAP reveals its essential role in B cells.
  2. this study has identified a critical role for Trrap in the mechanism that maintains hematopoietic stem cells and hematopoietic system, and underscores the importance of Trrap and histone modifications in tissue homeostasis.
    Title: Histone acetyltransferase cofactor Trrap is essential for maintaining the hematopoietic stem/progenitor cell pool.
  3. Fe65 and its interaction with APP play an important role in the response to DNA damage by assisting the recruitment
    Title: Fe65 is required for Tip60-directed histone H4 acetylation at DNA strand breaks.
  4. expression profiles of Trrap-responsive genes, using cDNA microarray in mitotic cells
    Title: Genome-wide analysis of gene expression regulated by the HAT cofactor Trrap in conditional knockout cells.
  5. HAT cofactor Trrap and Tip60 HAT bind to the chromatin surrounding sites of DNA double-strand breaks (DSBs). Cells may use the same basic mechanism involving HAT complexes to regulate distinct cellular processes, such as transcription and DNA repair.
    Title: Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks.
  6. Data show that the loss of Trrap leads to chromosome missegregation, mitotic exit failure and compromised mitotic checkpoints, which are caused by defective Trrap-mediated transcription of the mitotic checkpoint proteins Mad1 and Mad2.
    Title: HAT cofactor Trrap regulates the mitotic checkpoint by modulation of Mad1 and Mad2 expression.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mitotic cell cycle checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA repair NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of RNA splicing NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of apoptotic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of double-strand break repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
part_of NuA4 histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of SAGA complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SAGA complex ISO
Inferred from Sequence Orthology
more info
  
part_of SAGA complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of Swr1 complex ISO
Inferred from Sequence Orthology
more info
  
part_of histone acetyltransferase complex TAS
Traceable Author Statement
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFTC complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFTC complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transformation/transcription domain-associated protein
Names
tra1 homolog
transactivation/transformation-domain associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081362.2 → NP_001074831.1  transformation/transcription domain-associated protein

    Status: VALIDATED

    Source sequence(s)
    AC113295, AC131728
    Consensus CDS
    CCDS39379.1
    UniProtKB/TrEMBL
    E9PZA7, E9QLK7
    Related
    ENSMUSP00000098035.4, ENSMUST00000100467.10
    Conserved Domains (3) summary
    COG5032
    Location:2526 → 3847
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:3484 → 3771
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:2842 → 3174
    FAT; FAT domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    144704547..144796588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504782.3 → XP_006504845.1  transformation/transcription domain-associated protein isoform X1

    See identical proteins and their annotated locations for XP_006504845.1

    UniProtKB/TrEMBL
    A0A1D5RLL4
    Conserved Domains (3) summary
    COG5032
    Location:2552 → 3911
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:3522 → 3835
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:2868 → 3211
    FAT; FAT domain

  2. XM_030254015.1 → XP_030109875.1  transformation/transcription domain-associated protein isoform X3

    UniProtKB/TrEMBL
    E9PWT1
    Conserved Domains (3) summary
    COG5032
    Location:2551 → 3910
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:3521 → 3834
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:2867 → 3210
    FAT; FAT domain

  3. XM_006504781.3 → XP_006504844.1  transformation/transcription domain-associated protein isoform X1

    See identical proteins and their annotated locations for XP_006504844.1

    UniProtKB/TrEMBL
    A0A1D5RLL4
    Conserved Domains (3) summary
    COG5032
    Location:2552 → 3911
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:3522 → 3835
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:2868 → 3211
    FAT; FAT domain

  4. XM_006504789.3 → XP_006504852.1  transformation/transcription domain-associated protein isoform X10

    UniProtKB/TrEMBL
    A0A1D5RLL4
    Conserved Domains (3) summary
    COG5032
    Location:2552 → 3885
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:3522 → 3809
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:2868 → 3211
    FAT; FAT domain

  5. XM_006504787.3 → XP_006504850.1  transformation/transcription domain-associated protein isoform X7

    UniProtKB/TrEMBL
    A0A1D5RLL4
    Conserved Domains (3) summary
    COG5032
    Location:2552 → 3893
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:3504 → 3817
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:2868 → 3211
    FAT; FAT domain

  6. XM_006504784.3 → XP_006504847.1  transformation/transcription domain-associated protein isoform X2

    UniProtKB/TrEMBL
    A0A1D5RLL4
    Conserved Domains (3) summary
    COG5032
    Location:2552 → 3910
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:3521 → 3834
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:2868 → 3211
    FAT; FAT domain

  7. XM_006504790.3 → XP_006504853.1  transformation/transcription domain-associated protein isoform X11

    UniProtKB/TrEMBL
    A0A1D5RLL4
    Conserved Domains (2) summary
    COG5032
    Location:2552 → 3884
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:3521 → 3808
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein

  8. XM_030254018.1 → XP_030109878.1  transformation/transcription domain-associated protein isoform X8

    UniProtKB/TrEMBL
    A0A1D5RLL4
    Conserved Domains (3) summary
    COG5032
    Location:2552 → 3892
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:3503 → 3816
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:2868 → 3211
    FAT; FAT domain

  9. XM_006504793.3 → XP_006504856.1  transformation/transcription domain-associated protein isoform X15

    UniProtKB/TrEMBL
    A0A1D5RLL4
    Related
    ENSMUSP00000148419.2, ENSMUST00000213013.2
    Conserved Domains (2) summary
    COG5032
    Location:2552 → 3866
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:3503 → 3790
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein

  10. XM_006504786.3 → XP_006504849.1  transformation/transcription domain-associated protein isoform X4

    UniProtKB/TrEMBL
    A0A1D5RLL4
    Conserved Domains (3) summary
    COG5032
    Location:2552 → 3900
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:3511 → 3824
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:2868 → 3200
    FAT; FAT domain

  11. XM_017320576.2 → XP_017176065.1  transformation/transcription domain-associated protein isoform X13

    UniProtKB/TrEMBL
    A0A1D5RLL4
    Conserved Domains (3) summary
    COG5032
    Location:2552 → 3874
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:3511 → 3798
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:2868 → 3200
    FAT; FAT domain

  12. XM_017320575.2 → XP_017176064.1  transformation/transcription domain-associated protein isoform X5

    UniProtKB/TrEMBL
    A0A1D5RLL4
    Conserved Domains (3) summary
    COG5032
    Location:2552 → 3899
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:3510 → 3823
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:2868 → 3200
    FAT; FAT domain

  13. XM_036164690.1 → XP_036020583.1  transformation/transcription domain-associated protein isoform X12

    UniProtKB/TrEMBL
    A0A1D5RLL4
    Conserved Domains (3) summary
    COG5032
    Location:2552 → 3881
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:3492 → 3805
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:2858 → 3200
    FAT; FAT domain

  14. XM_017320577.2 → XP_017176066.1  transformation/transcription domain-associated protein isoform X16

    UniProtKB/TrEMBL
    A0A1D5RLL4
    Conserved Domains (3) summary
    COG5032
    Location:2552 → 3855
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:3492 → 3779
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:2868 → 3200
    FAT; FAT domain

  15. XM_011240999.3 → XP_011239301.1  transformation/transcription domain-associated protein isoform X6

    UniProtKB/TrEMBL
    A0A1D5RLL4
    Conserved Domains (3) summary
    COG5032
    Location:2534 → 3893
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:3504 → 3817
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:2850 → 3193
    FAT; FAT domain

  16. XM_006504788.3 → XP_006504851.1  transformation/transcription domain-associated protein isoform X9

    UniProtKB/TrEMBL
    E9PZA7
    Conserved Domains (3) summary
    COG5032
    Location:2527 → 3886
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:3497 → 3810
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:2843 → 3186
    FAT; FAT domain

  17. XM_006504795.3 → XP_006504858.1  transformation/transcription domain-associated protein isoform X19

    UniProtKB/TrEMBL
    E9PZA7
    Conserved Domains (3) summary
    COG5032
    Location:2527 → 3830
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:3467 → 3754
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:2843 → 3175
    FAT; FAT domain

  18. XM_006504785.3 → XP_006504848.1  transformation/transcription domain-associated protein isoform X3

    UniProtKB/TrEMBL
    E9PWT1
    Conserved Domains (3) summary
    COG5032
    Location:2551 → 3910
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:3521 → 3834
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:2867 → 3210
    FAT; FAT domain

  19. XM_006504792.4 → XP_006504855.1  transformation/transcription domain-associated protein isoform X14

    UniProtKB/TrEMBL
    A0A1D5RLL4
    Related
    ENSMUSP00000122021.2, ENSMUST00000132925.2
    Conserved Domains (3) summary
    COG5032
    Location:2552 → 3873
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:3510 → 3797
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:2868 → 3200
    FAT; FAT domain

  20. XM_006504794.4 → XP_006504857.1  transformation/transcription domain-associated protein isoform X17

    UniProtKB/TrEMBL
    E9PZA7
    Conserved Domains (3) summary
    COG5032
    Location:2527 → 3848
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:3485 → 3772
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:2843 → 3175
    FAT; FAT domain

  21. XM_017320578.3 → XP_017176067.1  transformation/transcription domain-associated protein isoform X18

    UniProtKB/TrEMBL
    E9PZA7, E9QLK7
    Conserved Domains (3) summary
    COG5032
    Location:2526 → 3847
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:3484 → 3771
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:2842 → 3174
    FAT; FAT domain

  22. XM_006504783.4 → XP_006504846.1  transformation/transcription domain-associated protein isoform X1

    See identical proteins and their annotated locations for XP_006504846.1

    UniProtKB/TrEMBL
    A0A1D5RLL4
    Conserved Domains (3) summary
    COG5032
    Location:2552 → 3911
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:3522 → 3835
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:2868 → 3211
    FAT; FAT domain

  23. XM_030254016.1 → XP_030109876.1  transformation/transcription domain-associated protein isoform X3

    UniProtKB/TrEMBL
    E9PWT1
    Conserved Domains (3) summary
    COG5032
    Location:2551 → 3910
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:3521 → 3834
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:2867 → 3210
    FAT; FAT domain

RNA

  1. XR_377190.4 RNA Sequence

  2. XR_377189.4 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_133901.2: Suppressed sequence

    Description
    NM_133901.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80YV3.2 GenPept UniProtKB/Swiss-Prot:Q80YV3

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