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ERVK-10 endogenous retrovirus group K member 10 [ Homo sapiens (human) ]

Gene ID: 100616101, updated on 11-Apr-2024

Summary

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Official Symbol
ERVK-10provided by HGNC
Official Full Name
endogenous retrovirus group K member 10provided by HGNC
Primary source
HGNC:HGNC:39004
Gene type
other
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PR; Protease; Proteinase
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Genomic context

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Location:
5q33.3

Bibliography

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Related articles in PubMed

  1. Activation of HERV-K Env protein is essential for tumorigenesis and metastasis of breast cancer cells. Zhou F, et al. Oncotarget, 2016 Dec 20. PMID 27557521, Free PMC Article
  2. Inhibition of human endogenous retrovirus-K10 protease in cell-free and cell-based assays. Kuhelj R, et al. J Biol Chem, 2001 May 18. PMID 11278433
  3. Functional characterization of the protease of human endogenous retrovirus, K10: can it complement HIV-1 protease? Towler EM, et al. Biochemistry, 1998 Dec 8. PMID 9860826
  4. Characterization of human endogenous retrovirus type K virus-like particles generated from recombinant baculoviruses. Tönjes RR, et al. Virology, 1997 Jul 7. PMID 9217052
  5. Characterization of the human endogenous retrovirus K proteinase. Schommer S, et al. J Gen Virol, 1996 Feb. PMID 8627242

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results indicate that human endogenous retrovirus type K (HERV-K10) Env protein plays an important role in tumorigenesis and metastasis of breast cancer (BC).
    Title: Activation of HERV-K Env protein is essential for tumorigenesis and metastasis of breast cancer cells.
  2. Np9 contributes to the regulation of the p53-MDM2 pathway specifically in humans, chimpanzees and gorillas.
    Title: Np9, a cellular protein of retroviral ancestry restricted to human, chimpanzee and gorilla, binds and regulates ubiquitin ligase MDM2.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • Endogenous retrovirus group K member 10 Np9 protein
  • Gag polyprotein
  • Gag-Pro-Pol protein
  • HERV-K10 Np9 protein
  • HERV-K107 Np9 protein
  • HERV-K_5q33.3 provirus Np9 protein
  • HERV-K_5q33.3 provirus ancestral Gag polyprotein
  • HERV-K_5q33.3 provirus ancestral Pol protein
  • HERV-K_5q33.3 provirus ancestral Pro protein

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA stem-loop binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA-DNA hybrid ribonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA integration IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA synthesis involved in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA-templated DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA-templated DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P10265.2 GenPept UniProtKB/Swiss-Prot:P10265
P10266.2 GenPept UniProtKB/Swiss-Prot:P10266
P61580.1 GenPept UniProtKB/Swiss-Prot:P61580
P87889.4 GenPept UniProtKB/Swiss-Prot:P87889

Gene LinkOut

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