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Dchs2 dachsous cadherin related 2 [ Mus musculus (house mouse) ]

Gene ID: 100534287, updated on 21-Apr-2024

Summary

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Official Symbol
Dchs2provided by MGI
Official Full Name
dachsous cadherin related 2provided by MGI
Primary source
MGI:MGI:2685263
See related
Ensembl:ENSMUSG00000102692 AllianceGenome:MGI:2685263
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm417; Gm6731; EG627094
Summary
Predicted to enable calcium ion binding activity. Acts upstream of or within condensed mesenchymal cell proliferation and nephron development. Predicted to be active in cell-cell junction. Is expressed in brain; pharyngo-tympanic tube; and spinal cord. Orthologous to human DCHS2 (dachsous cadherin-related 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human all
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Genomic context

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Location:
3; 3 E3
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (83032589..83270336)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (83126944..83363029)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08044 Neighboring gene STARR-seq mESC enhancer starr_08045 Neighboring gene STARR-positive B cell enhancer mm9_chr3:82859171-82859472 Neighboring gene pleiotropic regulator 1 Neighboring gene fibrinogen beta chain Neighboring gene predicted gene 10710 Neighboring gene STARR-seq mESC enhancer starr_08046 Neighboring gene STARR-seq mESC enhancer starr_08047 Neighboring gene STARR-seq mESC enhancer starr_08048 Neighboring gene STARR-seq mESC enhancer starr_08049 Neighboring gene STARR-seq mESC enhancer starr_08050 Neighboring gene STARR-seq mESC enhancer starr_08051 Neighboring gene predicted gene, 54183 Neighboring gene RIKEN cDNA 1700028M03 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Planar cell polarity-dependent asymmetric organization of microtubules for polarized positioning of the basal body in node cells. Sai X, et al. Development, 2022 May 1. PMID 35420656
  2. Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila. Rock R, et al. Dev Dyn, 2005 Nov. PMID 16059920
  3. Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development. Mao Y, et al. Development, 2011 Mar. PMID 21303848, Free PMC Article
  4. Stromal Fat4 acts non-autonomously with Dchs1/2 to restrict the nephron progenitor pool. Bagherie-Lachidan M, et al. Development, 2015 Aug 1. PMID 26116661
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within condensed mesenchymal cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within nephron development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protocadherin-23
Names
dachsous 2
protocadherin alpha 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357165.2 → NP_001344094.1  protocadherin-23

    Status: VALIDATED

    Source sequence(s)
    AC107700, AC138394
    Consensus CDS
    CCDS89642.1
    UniProtKB/TrEMBL
    A0A0A6YW72
    Related
    ENSMUSP00000141425.2, ENSMUST00000191829.2
    Conserved Domains (1) summary
    cd11304
    Location:2224 → 2321
    Cadherin_repeat; Cadherin tandem repeat domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    83032589..83270336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162801.1 → XP_036018694.1  protocadherin-23 isoform X1

    Conserved Domains (1) summary
    cd11304
    Location:2224 → 2321
    Cadherin_repeat; Cadherin tandem repeat domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_028362.1: Suppressed sequence

    Description
    NG_028362.1: This RefSeq is suppressed as the gene is not considered to be a pseudogene.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.