Fer1l5 fer-1 like family member 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fer1l5provided by MGI
Official Full Name: fer-1 like family member 5provided by MGI
Primary source: MGI:MGI:3616091
See related: Ensembl:ENSMUSG00000037432 AllianceGenome:MGI:3616091
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4930533C12Rik
Summary: Predicted to enable calcium ion binding activity and calcium-dependent phospholipid binding activity. Predicted to be involved in several processes, including myeloid cell activation involved in immune response; negative regulation of phagocytosis; and plasma membrane organization. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in T-tubule and cytoplasmic vesicle. Orthologous to human FER1L5 (fer-1 like family member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 20.5) and thymus adult (RPKM 1.0) See more
Orthologs: human all
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Genomic context

Location:: 1 B; 1 15.26 cM

Exon count:: 47

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (36411264..36461191)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (36372183..36422110)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Testis-enriched ferlin, FER1L5, is required for Ca[2+]-activated acrosome reaction and male fertility.
Title: Testis-enriched ferlin, FER1L5, is required for Ca(2+)-activated acrosome reaction and male fertility.
The characterization of Fer1L5 and its interaction with EHD1 and EHD2 underscores the complex requirement of ferlin proteins and mediators of endocytic recycling for membrane trafficking events during myotube formation
Title: Endocytic recycling proteins EHD1 and EHD2 interact with fer-1-like-5 (Fer1L5) and mediate myoblast fusion.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in T-tubule organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in macrophage activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in monocyte activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of phagocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in plasma membrane repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in T-tubule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fer-1-like protein 5

Names: fer-1-like 5 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001277076.2 → NP_001264005.1 fer-1-like protein 5

See identical proteins and their annotated locations for NP_001264005.1

Status: VALIDATED

Source sequence(s)

AC132456

Consensus CDS

CCDS78562.1

UniProtKB/Swiss-Prot

M1J7P7, P0DM40

Related

ENSMUSP00000142130.2, ENSMUST00000179162.7

Conserved Domains (10) summary

cd04011
Location:164 → 271

C2B_Ferlin; C2 domain second repeat in Ferlin

cd04017
Location:1077 → 1212

C2D_Ferlin; C2 domain fourth repeat in Ferlin

cd04037
Location:1487 → 1610

C2E_Ferlin; C2 domain fifth repeat in Ferlin

cd08374
Location:1722 → 1854

C2F_Ferlin; C2 domain sixth repeat in Ferlin

smart00693
Location:781 → 836

DysFN; Dysferlin domain, N-terminal region

pfam08150
Location:692 → 763

FerB; FerB (NUC096) domain

pfam08151
Location:276 → 297

FerI; FerI (NUC094) domain

pfam08165
Location:615 → 650

FerA; FerA (NUC095) domain

pfam16165
Location:1870 → 1984

Ferlin_C; Ferlin C-terminus

cl14603
Location:5 → 134

C2; C2 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

36411264..36461191

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163502.1 → XP_036019395.1 fer-1-like protein 5 isoform X1

Conserved Domains (8) summary

cd04011
Location:164 → 271

C2B_Ferlin; C2 domain second repeat in Ferlin

cd04017
Location:1077 → 1212

C2D_Ferlin; C2 domain fourth repeat in Ferlin

cd04037
Location:1447 → 1570

C2E_Ferlin; C2 domain fifth repeat in Ferlin

smart00693
Location:781 → 836

DysFN; Dysferlin domain, N-terminal region

pfam08150
Location:691 → 763

FerB; FerB (NUC096) domain

pfam08151
Location:276 → 297

FerI; FerI (NUC094) domain

pfam08165
Location:615 → 650

FerA; FerA (NUC095) domain

cl14603
Location:5 → 134

C2; C2 domain
XM_030253122.1 → XP_030108982.1 fer-1-like protein 5 isoform X2

Conserved Domains (8) summary

cd04011
Location:164 → 271

C2B_Ferlin; C2 domain second repeat in Ferlin

cd04017
Location:1034 → 1169

C2D_Ferlin; C2 domain fourth repeat in Ferlin

cd04037
Location:1444 → 1567

C2E_Ferlin; C2 domain fifth repeat in Ferlin

smart00693
Location:743 → 793

DysFN; Dysferlin domain, N-terminal region

pfam08150
Location:692 → 743

FerB; FerB (NUC096) domain

pfam08151
Location:276 → 297

FerI; FerI (NUC094) domain

pfam08165
Location:615 → 650

FerA; FerA (NUC095) domain

cl14603
Location:5 → 134

C2; C2 domain
XM_006495604.2 → XP_006495667.1 fer-1-like protein 5 isoform X4

Conserved Domains (7) summary

cd04011
Location:164 → 271

C2B_Ferlin; C2 domain second repeat in Ferlin

cd04017
Location:1077 → 1212

C2D_Ferlin; C2 domain fourth repeat in Ferlin

smart00693
Location:781 → 836

DysFN; Dysferlin domain, N-terminal region

pfam08150
Location:692 → 763

FerB; FerB (NUC096) domain

pfam08151
Location:276 → 297

FerI; FerI (NUC094) domain

pfam08165
Location:615 → 650

FerA; FerA (NUC095) domain

cl14603
Location:5 → 134

C2; C2 domain
XM_006495602.2 → XP_006495665.1 fer-1-like protein 5 isoform X3

Conserved Domains (7) summary

cd04011
Location:164 → 271

C2B_Ferlin; C2 domain second repeat in Ferlin

cd04017
Location:1077 → 1212

C2D_Ferlin; C2 domain fourth repeat in Ferlin

smart00693
Location:781 → 836

DysFN; Dysferlin domain, N-terminal region

pfam08150
Location:692 → 763

FerB; FerB (NUC096) domain

pfam08151
Location:276 → 297

FerI; FerI (NUC094) domain

pfam08165
Location:615 → 650

FerA; FerA (NUC095) domain

cl14603
Location:5 → 134

C2; C2 domain
XM_006495605.3 → XP_006495668.1 fer-1-like protein 5 isoform X5

Conserved Domains (6) summary

cd04011
Location:164 → 271

C2B_Ferlin; C2 domain second repeat in Ferlin

smart00693
Location:781 → 836

DysFN; Dysferlin domain, N-terminal region

pfam08150
Location:692 → 763

FerB; FerB (NUC096) domain

pfam08151
Location:276 → 297

FerI; FerI (NUC094) domain

pfam08165
Location:615 → 650

FerA; FerA (NUC095) domain

cl14603
Location:5 → 134

C2; C2 domain
XM_030253213.1 → XP_030109073.1 fer-1-like protein 5 isoform X6

Conserved Domains (5) summary

cd04017
Location:494 → 629

C2D_Ferlin; C2 domain fourth repeat in Ferlin

cd04037
Location:904 → 1027

C2E_Ferlin; C2 domain fifth repeat in Ferlin

smart00693
Location:198 → 253

DysFN; Dysferlin domain, N-terminal region

pfam08150
Location:109 → 180

FerB; FerB (NUC096) domain

pfam08165
Location:32 → 67

FerA; FerA (NUC095) domain
XM_030253230.1 → XP_030109090.1 fer-1-like protein 5 isoform X6

Conserved Domains (5) summary

cd04017
Location:494 → 629

C2D_Ferlin; C2 domain fourth repeat in Ferlin

cd04037
Location:904 → 1027

C2E_Ferlin; C2 domain fifth repeat in Ferlin

smart00693
Location:198 → 253

DysFN; Dysferlin domain, N-terminal region

pfam08150
Location:109 → 180

FerB; FerB (NUC096) domain

pfam08165
Location:32 → 67

FerA; FerA (NUC095) domain

RNA

XR_004941790.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NG_028631.1: Suppressed sequence

Description

NG_028631.1: This RefSeq was permanently suppressed because it is now thought that this pseudogene is transcribed.