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ZHX1-C8orf76 ZHX1-C8orf76 readthrough [ Homo sapiens (human) ]

Gene ID: 100533106, updated on 8-Mar-2024

Summary

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Official Symbol
ZHX1-C8orf76provided by HGNC
Official Full Name
ZHX1-C8orf76 readthroughprovided by HGNC
Primary source
HGNC:HGNC:42975
See related
Ensembl:ENSG00000259305 AllianceGenome:HGNC:42975
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This locus represents naturally occurring read-through transcription between the neighboring zinc fingers and homeoboxes 1 (ZHX1) and chromosome 8 open reading frame 76 (C8orf76) genes. The read-through transcript encodes a protein that shares sequence identity with the downstream gene, but it has a distinct N-terminus encoded by exon structure from the upstream gene. [provided by RefSeq, Feb 2011]
Expression
Ubiquitous expression in fat (RPKM 7.0), colon (RPKM 6.8) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
8q24.13
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (123226191..123274286, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (124357328..124405423, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (124238431..124286526, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 83 member A Neighboring gene FAM83A antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:124219477-124220229 Neighboring gene microRNA 4663 Neighboring gene chromosome 8 open reading frame 76 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:124253403-124253903 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27870 Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene 5 Neighboring gene tRNA-Phe (anticodon GAA) 12-1 Neighboring gene small nucleolar RNA U13 Neighboring gene RNA, U6 small nuclear 628, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr8:124285783-124286150 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19496 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19497 Neighboring gene zinc fingers and homeoboxes 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27871 Neighboring gene hydroxysteroid 17-beta dehydrogenase 4 pseudogene Neighboring gene Sharpr-MPRA regulatory region 1385 Neighboring gene ATPase family AAA domain containing 2 Neighboring gene RNA, U6 small nuclear 875, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. Prakash T, et al. PLoS One, 2010 Oct 12. PMID 20967262, Free PMC Article
  2. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. Suzuki Y, et al. Genome Res, 2004 Sep. PMID 15342556, Free PMC Article
  3. Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. Haenig C, et al. Cell Rep, 2020 Aug 18. PMID 32814053
  4. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC9784

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
zinc fingers and homeoboxes protein 1, isoform 2
Names
ZHX1-C8orf76 readthrough transcript protein
zinc fingers and homeoboxes protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204180.2 → NP_001191109.1  zinc fingers and homeoboxes protein 1, isoform 2

    See identical proteins and their annotated locations for NP_001191109.1

    Status: VALIDATED

    Source sequence(s)
    AC018992, BC012379, BP340117
    UniProtKB/Swiss-Prot
    Q96EF9
    Related
    ENSP00000349593.4, ENST00000357082.8
    Conserved Domains (2) summary
    sd00006
    Location:98 → 127
    TPR; TPR repeat [structural motif]
    cl26178
    Location:32 → 167
    pgaA; outer membrane protein PgaA; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    123226191..123274286 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    124357328..124405423 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96EF9.1 GenPept UniProtKB/Swiss-Prot:Q96EF9

Gene LinkOut

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