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CHURC1-FNTB CHURC1-FNTB readthrough [ Homo sapiens (human) ]

Gene ID: 100529261, updated on 8-Mar-2024

Summary

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Official Symbol
CHURC1-FNTBprovided by HGNC
Official Full Name
CHURC1-FNTB readthroughprovided by HGNC
Primary source
HGNC:HGNC:42960
See related
Ensembl:ENSG00000125954 AllianceGenome:HGNC:42960
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FNTB; FTase-beta
Summary
This locus represents naturally occurring read-through transcription between the neighboring CHURC1 (churchill domain containing 1) and FNTB (farnesyltransferase, CAAX box, beta) on chromosome 14. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Feb 2011]
Expression
Ubiquitous expression in testis (RPKM 10.7), brain (RPKM 10.1) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
14q23.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (64914361..65062655)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (59119229..59267513)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (65381079..65529373)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370534 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8537 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8538 Neighboring gene ribonuclease P RNA component H1, 2 pseudogene Neighboring gene MPRA-validated peak2167 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8539 Neighboring gene churchill domain containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:65421611-65422488 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:65426829-65427347 Neighboring gene glutathione peroxidase 2 Neighboring gene RAB15, member RAS oncogene family Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5845 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:65441391-65442168 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:65448241-65448742 Neighboring gene uncharacterized LOC107984655 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8540 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:65471811-65473010 Neighboring gene farnesyltransferase, CAAX box, subunit beta Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5846 Neighboring gene MYC associated factor X Neighboring gene microRNA 4706 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:65544121-65545096 Neighboring gene uncharacterized LOC100506321 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:65568306-65568806 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5847 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8541 Neighboring gene RNA, U2 small nuclear 14, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. Ganesh SK, et al. Nat Genet, 2009 Nov. PMID 19862010, Free PMC Article
  2. Genome-wide association study identifies loci affecting blood copper, selenium and zinc. Evans DM, et al. Hum Mol Genet, 2013 Oct 1. PMID 23720494, Free PMC Article
  3. Seventy-five genetic loci influencing the human red blood cell. van der Harst P, et al. Nature, 2012 Dec 20. PMID 23222517, Free PMC Article
  4. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. Prakash T, et al. PLoS One, 2010 Oct 12. PMID 20967262, Free PMC Article
  5. Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer. Vichas A, et al. Nat Commun, 2021 Aug 9. PMID 34373451, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
EBI GWAS Catalog
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.
EBI GWAS Catalog
Seventy-five genetic loci influencing the human red blood cell.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ58825, FLJ59570

General protein information

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Preferred Names
CHURC1-FNTB protein
Names
CAAX farnesyltransferase subunit beta
Protein farnesyltransferase subunit beta
Ras proteins prenyltransferase subunit beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001202558.2 → NP_001189487.1  CHURC1-FNTB protein isoform 2

    See identical proteins and their annotated locations for NP_001189487.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region and uses a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK303739, AL135745, AL139022
    UniProtKB/TrEMBL
    Q86TX8
    Conserved Domains (2) summary
    PLN02710
    Location:4 → 373
    PLN02710; farnesyltranstransferase subunit beta
    cd02893
    Location:29 → 327
    FTase; Protein farnesyltransferase (FTase)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). FTases are a subgroup of PTase family of lipid-modifying enzymes. PTases catalyze the ...

  2. NM_001202559.1 → NP_001189488.1  CHURC1-FNTB protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK296850, AL135745, AL139022
    UniProtKB/TrEMBL
    B4DL54, H0YHI0
    Related
    ENSP00000447121.2, ENST00000549987.1
    Conserved Domains (3) summary
    PLN02710
    Location:109 → 480
    PLN02710; farnesyltranstransferase subunit beta
    cd02893
    Location:136 → 434
    FTase; Protein farnesyltransferase (FTase)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). FTases are a subgroup of PTase family of lipid-modifying enzymes. PTases catalyze the ...
    pfam06573
    Location:28 → 109
    Churchill; Churchill protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    64914361..65062655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    59119229..59267513
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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