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ZNF559-ZNF177 ZNF559-ZNF177 readthrough [ Homo sapiens (human) ]

Gene ID: 100529215, updated on 11-Apr-2024

Summary

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Official Symbol
ZNF559-ZNF177provided by HGNC
Official Full Name
ZNF559-ZNF177 readthroughprovided by HGNC
Primary source
HGNC:HGNC:42964
See related
Ensembl:ENSG00000270011 AllianceGenome:HGNC:42964
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This locus represents naturally occurring read-through transcription between the neighboring zinc finger protein 559 (ZNF559) and zinc finger protein 177 (ZNF177) genes on chromosome 19. Alternative splicing results in multiple transcript variants, which encode the ZNF177 protein due to either leaky scanning by ribosomes, or absence of the ZNF559 start codon. [provided by RefSeq, Jan 2011]
Expression
Broad expression in testis (RPKM 5.0), ovary (RPKM 3.1) and 22 other tissues See more
Orthologs
all
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Genomic context

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Location:
19p13.2
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (9324179..9382617)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (9450390..9508854)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (9434855..9493293)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 7 subfamily H member 1 pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr19:9406829-9407424 Neighboring gene zinc finger protein 699 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10037 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13927 Neighboring gene Sharpr-MPRA regulatory region 15409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13928 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10038 Neighboring gene zinc finger protein 559 Neighboring gene UBXN2A pseudogene 1 Neighboring gene zinc finger protein 177 Neighboring gene uncharacterized LOC112268250 Neighboring gene zinc finger protein 266 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13929

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Repetitive elements in the 5' untranslated region of a human zinc-finger gene modulate transcription and translation efficiency. Landry JR, et al. Genomics, 2001 Aug. PMID 11549323
  2. Transcripts from a novel human KRAB zinc finger gene contain spliced Alu and endogenous retroviral segments. Baban S, et al. Genomics, 1996 May 1. PMID 8661005
  3. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. Prakash T, et al. PLoS One, 2010 Oct 12. PMID 20967262, Free PMC Article
  4. Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. Bastos-Amador P, et al. J Proteomics, 2012 Jun 27. PMID 22516433
  5. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Yin Y, et al. Science, 2017 May 5. PMID 28473536, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in blood microparticle HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 177

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172650.3 → NP_001166121.1  zinc finger protein 177 isoform b

    See identical proteins and their annotated locations for NP_001166121.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains alternate exon structure in the 5' UTR, uses an alternate splice site that causes a frameshift in the 3' coding region, and lacks a segment of the 3' UTR, compared to variant 4. The resulting isoform (b) has a distinct and longer C-terminus, compared to isoform c. A non-read-through variant of the downstream ZNF177 gene, as represented by GeneID:7730, also encodes isoform b.
    Source sequence(s)
    AC011451, BC034489
    UniProtKB/Swiss-Prot
    Q13360
    Related
    ENSP00000445323.1, ENST00000541595.6
    Conserved Domains (4) summary
    smart00349
    Location:14 → 70
    KRAB; krueppel associated box
    COG5048
    Location:87 → 282
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:126 → 146
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:279 → 303
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001202425.1 → NP_001189354.1  zinc finger protein 177 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longer transcript but encodes the shorter isoform (c).
    Source sequence(s)
    AC011451, BC034489, U37251
    UniProtKB/TrEMBL
    V9H066
    Related
    ENSP00000413568.2, ENST00000446085.8
    Conserved Domains (2) summary
    smart00349
    Location:14 → 70
    KRAB; krueppel associated box
    pfam01352
    Location:14 → 53
    KRAB; KRAB box

  3. NM_001384659.1 → NP_001371588.1  zinc finger protein 177 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC011451
    UniProtKB/Swiss-Prot
    B4DY57, E9PDG0, I3L0I4, Q13360, Q96ER2
    Conserved Domains (4) summary
    smart00349
    Location:14 → 70
    KRAB; krueppel associated box
    COG5048
    Location:212 → 442
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:286 → 306
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:439 → 463
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    9324179..9382617
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    9450390..9508854
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13360.4 GenPept UniProtKB/Swiss-Prot:Q13360

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