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LY75-CD302 LY75-CD302 readthrough [ Homo sapiens (human) ]

Gene ID: 100526664, updated on 8-Mar-2024

Summary

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Official Symbol
LY75-CD302provided by HGNC
Official Full Name
LY75-CD302 readthroughprovided by HGNC
Primary source
HGNC:HGNC:38828
See related
Ensembl:ENSG00000248672 AllianceGenome:HGNC:38828
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LY75; CD205; Ly-75; CLEC13B; DEC-205; gp200-MR6
Summary
This locus represents naturally occurring read-through transcription between the neighboring lymphocyte antigen 75 (LY75) and CD302 molecule (CD302) genes. Alternative splicing results in multiple transcript variants encoding fusion products that share sequence identity with each individual gene product. [provided by RefSeq, Nov 2010]
Expression
Ubiquitous expression in liver (RPKM 22.9), lung (RPKM 17.6) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
2q24.2
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (159768628..159904756, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (160225996..160363008, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (160625139..160761267, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene bromodomain adjacent to zinc finger domain 2B Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:160472595-160473121 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:160480245-160480746 Neighboring gene BAZ2B antisense RNA 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:160568592-160569258 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12044 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:160594100-160595092 Neighboring gene RPS3A pseudogene 13 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_53909 Neighboring gene membrane associated ring-CH-type finger 7 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_53950 Neighboring gene uncharacterized LOC124906083 Neighboring gene CD302 molecule Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16688 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16689 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16690 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12045 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16691 Neighboring gene lymphocyte antigen 75 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16692 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16693 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16694 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16695 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:160761228-160761469 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12047 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16696 Neighboring gene phospholipase A2 receptor 1 Neighboring gene uncharacterized LOC105373717 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:160911725-160912406 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16697 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:160982362-160982960 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:161037195-161037767 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:161037768-161038339 Neighboring gene integrin subunit beta 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1. Kato M, et al. J Biol Chem, 2003 Sep 5. PMID 12824192
  2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. Prakash T, et al. PLoS One, 2010 Oct 12. PMID 20967262, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Readthrough LY75-CD302

Included genes: LY75, CD302

Homology

General protein information

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Preferred Names
LY75-CD302 fusion protein
Names
C-type lectin domain family 13 member B
DEC-205/DCL-1 fusion
Lymphocyte antigen 75

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198759.1 → NP_001185688.1  LY75-CD302 fusion protein isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, also known as V34-2) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC009961, AC093873, AY184222
    UniProtKB/Swiss-Prot
    O60449
    Related
    ENSP00000423463.1, ENST00000504764.5
    Conserved Domains (5) summary
    smart00059
    Location:162 → 209
    FN2; Fibronectin type 2 domain
    cd00037
    Location:1115 → 1222
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    smart00034
    Location:361 → 486
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    smart00458
    Location:38 → 112
    RICIN; Ricin-type beta-trefoil
    cd00161
    Location:40 → 125
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

  2. NM_001198760.1 → NP_001185689.1  LY75-CD302 fusion protein isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2, also known as V33-2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC009961, AC093873, AY314006
    UniProtKB/Swiss-Prot
    O60449
    Related
    ENSP00000421035.1, ENST00000505052.1
    Conserved Domains (5) summary
    smart00059
    Location:162 → 209
    FN2; Fibronectin type 2 domain
    cd00037
    Location:1115 → 1222
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    smart00034
    Location:361 → 486
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    smart00458
    Location:38 → 112
    RICIN; Ricin-type beta-trefoil
    cd00161
    Location:40 → 125
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    159768628..159904756 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    160225996..160363008 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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