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ADAMTS9-AS2 ADAMTS9 antisense RNA 2 [ Homo sapiens (human) ]

Gene ID: 100507098, updated on 19-Feb-2024

Summary

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Official Symbol
ADAMTS9-AS2provided by HGNC
Official Full Name
ADAMTS9 antisense RNA 2provided by HGNC
Primary source
HGNC:HGNC:42435
See related
Ensembl:ENSG00000241684 AllianceGenome:HGNC:42435
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in ovary (RPKM 6.7), endometrium (RPKM 4.3) and 18 other tissues See more
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Genomic context

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Location:
3p14.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (64684870..65011468)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (64728534..65055119)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (64670546..64997143)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 739, pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:64526487-64527686 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 9 Neighboring gene ADAMTS9 antisense RNA 1 Neighboring gene NANOG hESC enhancer GRCh37_chr3:64582623-64583210 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:64627975-64628476 Neighboring gene NANOG hESC enhancer GRCh37_chr3:64663850-64664351 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:64670743-64671244 Neighboring gene uncharacterized LOC105377124 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:64930462-64931334 Neighboring gene MPRA-validated peak4685 silencer Neighboring gene uncharacterized LOC124909390 Neighboring gene MPRA-validated peak4686 silencer Neighboring gene uncharacterized LOC107986017

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A review on the role of ADAMTS9-AS2 in different disorders. Ghafouri-Fard S, et al. Pathol Res Pract, 2023 Mar. PMID 36746036
  2. ADAMTS9-AS2 Promotes Angiogenesis of Brain Microvascular Endothelial Cells Through Regulating miR-185-5p/IGFBP-2 Axis in Ischemic Stroke. Feng N, et al. Mol Neurobiol, 2022 Apr. PMID 35098480
  3. The diagnostic significance of circulating lncRNA ADAMTS9-AS2 tumor biomarker in non-small cell lung cancer among the Egyptian population. Abdul-Maksoud RS, et al. J Gene Med, 2021 Dec. PMID 34312940
  4. ADAMTS9-AS2: A Functional Long Non-coding RNA in Tumorigenesis. Xu W, et al. Curr Pharm Des, 2021. PMID 33823762
  5. Exosome-derived long non-coding RNA ADAMTS9-AS2 suppresses progression of oral submucous fibrosis via AKT signalling pathway. Zhou S, et al. J Cell Mol Med, 2021 Feb. PMID 33345447, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA ADAMTS9-AS2 regulates periodontal ligament cell migration under mechanical compression via ADAMTS9/fibronectin.
    Title: LncRNA ADAMTS9-AS2 regulates periodontal ligament cell migration under mechanical compression via ADAMTS9/fibronectin.
  2. A review on the role of ADAMTS9-AS2 in different disorders.
    Title: A review on the role of ADAMTS9-AS2 in different disorders.
  3. ADAMTS9-AS2 Promotes Angiogenesis of Brain Microvascular Endothelial Cells Through Regulating miR-185-5p/IGFBP-2 Axis in Ischemic Stroke.
    Title: ADAMTS9-AS2 Promotes Angiogenesis of Brain Microvascular Endothelial Cells Through Regulating miR-185-5p/IGFBP-2 Axis in Ischemic Stroke.
  4. The diagnostic significance of circulating lncRNA ADAMTS9-AS2 tumor biomarker in non-small cell lung cancer among the Egyptian population.
    Title: The diagnostic significance of circulating lncRNA ADAMTS9-AS2 tumor biomarker in non-small cell lung cancer among the Egyptian population.
  5. Long-Chain Noncoding RNA ADAMTS9-AS2 Regulates Proliferation, Migration, and Apoptosis in Bladder Cancer Cells Through Regulating miR-182-5p.
    Title: Long-Chain Noncoding RNA ADAMTS9-AS2 Regulates Proliferation, Migration, and Apoptosis in Bladder Cancer Cells Through Regulating miR-182-5p.
  6. ADAMTS9-AS2: A Functional Long Non-coding RNA in Tumorigenesis.
    Title: ADAMTS9-AS2: A Functional Long Non-coding RNA in Tumorigenesis.
  7. ADAMTS9-AS2 and CADM2 expression and association with the prognosis in esophageal squamous cell carcinoma.
    Title: ADAMTS9-AS2 and CADM2 expression and association with the prognosis in esophageal squamous cell carcinoma.
  8. Exosome-derived long non-coding RNA ADAMTS9-AS2 suppresses progression of oral submucous fibrosis via AKT signalling pathway.
    Title: Exosome-derived long non-coding RNA ADAMTS9-AS2 suppresses progression of oral submucous fibrosis via AKT signalling pathway.
  9. LncRNA ADAMTS9-AS2 suppresses the proliferation of gastric cancer cells and the tumorigenicity of cancer stem cells through regulating SPOP.
    Title: LncRNA ADAMTS9-AS2 suppresses the proliferation of gastric cancer cells and the tumorigenicity of cancer stem cells through regulating SPOP.
  10. LncRNA ADAMTS9-AS2 inhibits gastric cancer (GC) development and sensitizes chemoresistant GC cells to cisplatin by regulating miR-223-3p/NLRP3 axis.
    Title: LncRNA ADAMTS9-AS2 inhibits gastric cancer (GC) development and sensitizes chemoresistant GC cells to cisplatin by regulating miR-223-3p/NLRP3 axis.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
EBI GWAS Catalog
Genome-wide association analysis of age-at-onset in Alzheimer's disease.
EBI GWAS Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
EBI GWAS Catalog
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
EBI GWAS Catalog
Seven new loci associated with age-related macular degeneration.
EBI GWAS Catalog
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.
EBI GWAS Catalog
White matter integrity as an intermediate phenotype: exploratory genome-wide association analysis in individuals at high risk of bipolar disorder.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • ADAMTS9 antisense RNA 2 (non-protein coding)

Clone Names

  • DKFZp667E0523

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_038264.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC121766, AC132007, AL832788, BC040632, DA927615
    Related
    ENST00000481312.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    64684870..65011468
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    64728534..65055119
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases