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PANTR1 POU3F3 adjacent non-coding transcript 1 [ Homo sapiens (human) ]

Gene ID: 100506421, updated on 8-Mar-2024

Summary

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Official Symbol
PANTR1provided by HGNC
Official Full Name
POU3F3 adjacent non-coding transcript 1provided by HGNC
Primary source
HGNC:HGNC:49513
See related
Ensembl:ENSG00000233639 MIM:618169; AllianceGenome:HGNC:49513
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LINC01158; linc-Brn1a; linc-POU3F3
Summary
Predicted to act upstream of or within regulation of gene expression. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 2.2) and kidney (RPKM 1.6) See more
Orthologs
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Genomic context

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Location:
2q12.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (104805425..104853183, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (105265303..105314364, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (105421883..105469641, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:105362448-105363647 Neighboring gene long intergenic non-protein coding RNA 1114 Neighboring gene high mobility group box 3 pseudogene 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:105460844-105461368 Neighboring gene VISTA enhancer hs1553 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11835 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:105470177-105470766 Neighboring gene uncharacterized LOC124908045 Neighboring gene POU class 3 homeobox 3 Neighboring gene long intergenic non-protein coding RNA 1159

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Linc-POU3F3 is overexpressed in hepatocellular carcinoma and regulates cell proliferation, migration and invasion. Li Y, et al. Biomed Pharmacother, 2018 Sep. PMID 29906746
  2. Understanding the Role of lncRNAs in Nervous System Development. Clark BS, et al. Adv Exp Med Biol, 2017. PMID 28815543, Free PMC Article
  3. Glioma cells promote angiogenesis through the release of exosomes containing long non-coding RNA POU3F3. Lang HL, et al. Eur Rev Med Pharmacol Sci, 2017 Mar. PMID 28338200
  4. LncRNA POU3F3 Promotes Cancer Cell Proliferation, Migration, and Invasion in Renal Cell Carcinoma by Downregulating LncRNA GAS5. Zhang L, et al. Kidney Blood Press Res, 2021. PMID 34352801
  5. Long noncoding RNA POU3F3 enhances cancer cell proliferation, migration and invasion in non-small cell lung cancer (adenocarcinoma) by downregulating microRNA-30d-5p. Zeng Q, et al. BMC Pulm Med, 2020 Jul 2. PMID 32615948, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA POU3F3 Promotes Cancer Cell Proliferation, Migration, and Invasion in Renal Cell Carcinoma by Downregulating LncRNA GAS5.
    Title: LncRNA POU3F3 Promotes Cancer Cell Proliferation, Migration, and Invasion in Renal Cell Carcinoma by Downregulating LncRNA GAS5.
  2. lncRNA PANTR1 Upregulates BCL2A1 Expression to Promote Tumorigenesis and Warburg Effect of Hepatocellular Carcinoma through Restraining miR-587.
    Title: lncRNA PANTR1 Upregulates BCL2A1 Expression to Promote Tumorigenesis and Warburg Effect of Hepatocellular Carcinoma through Restraining miR-587.
  3. Long noncoding RNA POU3F3 enhances cancer cell proliferation, migration and invasion in non-small cell lung cancer (adenocarcinoma) by downregulating microRNA-30d-5p.
    Title: Long noncoding RNA POU3F3 enhances cancer cell proliferation, migration and invasion in non-small cell lung cancer (adenocarcinoma) by downregulating microRNA-30d-5p.
  4. LncRNA POU3F3 overexpression led to down-regulated TGF-beta1 expression, while exogenous TGF-b1 and TGF-b1 inhibitor treatment did not significantly change the expression level of lncRNA POU3F3. Therefore, lncRNA POU3F3 may promote cancer cell migration and invasion in nasopharyngeal carcinoma by up-regulating TGF-b1
    Title: LncRNA POU3F3 promotes cancer cell migration and invasion in nasopharyngeal carcinoma by up-regulating TGF-β1.
  5. Our study supports the first evidence that linc-POU3F3 plays an oncogenic role in hepatocellular carcinoma.
    Title: Linc-POU3F3 is overexpressed in hepatocellular carcinoma and regulates cell proliferation, migration and invasion.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Other Names

  • long intergenic non-protein coding RNA 1158

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_037883.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AC018730, AK096498, BF700938
    Related
    ENST00000443988.7

  2. NR_131233.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' terminal exon, uses an alternate splice site at an internal exon, and has a shorter 3' terminal exon, resulting in a shorter transcript than variant 1.
    Source sequence(s)
    AC018730, CK004193
    Related
    ENST00000447876.5

  3. NR_131234.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site at an internal exon and has a shorter 3' terminal exon, resulting in a shorter transcript than variant 1.
    Source sequence(s)
    AC018730, AL036798, BF700938
    Related
    ENST00000413121.7

  4. NR_131235.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site at an internal exon and has a shorter 3' terminal exon, resulting in a shorter transcript than variant 1.
    Source sequence(s)
    AC018730, AI879178, BF700938
    Related
    ENST00000454729.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    104805425..104853183 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    105265303..105314364 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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