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LINC01503 long intergenic non-protein coding RNA 1503 [ Homo sapiens (human) ]

Gene ID: 100506119, updated on 19-Feb-2024

Summary

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Official Symbol
LINC01503provided by HGNC
Official Full Name
long intergenic non-protein coding RNA 1503provided by HGNC
Primary source
HGNC:HGNC:51184
See related
Ensembl:ENSG00000233901 AllianceGenome:HGNC:51184
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in urinary bladder (RPKM 4.9), skin (RPKM 4.5) and 21 other tissues See more
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Genomic context

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Location:
9q34.11
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (129336923..129347477)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (141539091..141549647)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (132099202..132109756)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987133 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_106889 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29110 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20371 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29111 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:132083677-132084245 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:132084246-132084813 Neighboring gene long intergenic non-protein coding RNA 2913 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:132086855-132087356 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:132096285-132097484 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:132098075-132098878 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:132098879-132099682 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:132114579-132115380 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:132115381-132116180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:132120510-132121045 Neighboring gene uncharacterized LOC107987038 Neighboring gene RNA, 7SL, cytoplasmic 159, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Long Noncoding RNA LINC01503 Silencing Suppresses KLK4 Expression to Impede Pancreatic Cancer Development as miR-1321 Sponge. An B, et al. Biomed Res Int, 2023. PMID 36785666, Free PMC Article
  2. C-MYC-induced upregulation of LINC01503 promotes progression of non-small cell lung cancer. Zhang ML, et al. Eur Rev Med Pharmacol Sci, 2020 Nov. PMID 33215429
  3. LINC01503/miR-342-3p facilitates malignancy in non-small-cell lung cancer cells via regulating LASP1. Shen Q, et al. Respir Res, 2020 Sep 16. PMID 32938459, Free PMC Article
  4. LncRNA LINC01503 aggravates the progression of cervical cancer through sponging miR-342-3p to mediate FXYD3 expression. Peng X, et al. Biosci Rep, 2020 Jun 26. PMID 32432654, Free PMC Article
  5. Long Non-coding RNA LINC01503 Promotes Gastric Cancer Cell Proliferation and Invasion by Regulating Wnt Signaling. Ding J, et al. Dig Dis Sci, 2021 Feb. PMID 32207034

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Roles, underlying mechanisms and clinical significances of LINC01503 in human cancers.
    Title: Roles, underlying mechanisms and clinical significances of LINC01503 in human cancers.
  2. The transcript ENST00000444125 of lncRNA LINC01503 promotes cancer stem cell properties of glioblastoma cells via reducing FBXW1 mediated GLI2 degradation.
    Title: The transcript ENST00000444125 of lncRNA LINC01503 promotes cancer stem cell properties of glioblastoma cells via reducing FBXW1 mediated GLI2 degradation.
  3. LINC01503/miR-342-3p facilitates malignancy in non-small-cell lung cancer cells via regulating LASP1.
    Title: LINC01503/miR-342-3p facilitates malignancy in non-small-cell lung cancer cells via regulating LASP1.
  4. C-MYC-induced upregulation of LINC01503 promotes progression of non-small cell lung cancer.
    Title: C-MYC-induced upregulation of LINC01503 promotes progression of non-small cell lung cancer.
  5. Long Non-coding RNA LINC01503 Promotes Gastric Cancer Cell Proliferation and Invasion by Regulating Wnt Signaling.
    Title: Long Non-coding RNA LINC01503 Promotes Gastric Cancer Cell Proliferation and Invasion by Regulating Wnt Signaling.
  6. LncRNA LINC01503 aggravates the progression of cervical cancer through sponging miR-342-3p to mediate FXYD3 expression.
    Title: LncRNA LINC01503 aggravates the progression of cervical cancer through sponging miR-342-3p to mediate FXYD3 expression.
  7. EGR1-mediated linc01503 promotes cell cycle progression and tumorigenesis in gastric cancer.
    Title: EGR1-mediated linc01503 promotes cell cycle progression and tumorigenesis in gastric cancer.
  8. AR-induced long non-coding RNA LINC01503 facilitates proliferation and metastasis via the SFPQ-FOSL1 axis in nasopharyngeal carcinoma.
    Title: AR-induced long non-coding RNA LINC01503 facilitates proliferation and metastasis via the SFPQ-FOSL1 axis in nasopharyngeal carcinoma.
  9. LINC01503 promotes cell proliferation, invasion and EMT process in cholangio-carcinoma.
    Title: LINC01503 promotes cell proliferation, invasion and EMT process in cholangio-carcinoma.
  10. findings suggested that LINC01503 conferred oncogenic function in glioma and may be a new prognostic biomarker and novel therapeutic strategy for this malignancy
    Title: Long non-coding RNA LINC01503 predicts worse prognosis in glioma and promotes tumorigenesis and progression through activation of Wnt/β-catenin signaling.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Other Names

  • hCG2021613
  • lnc-PPP2R4-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_120685.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    BF432137, DA958985
    Related
    ENST00000660635.1

  2. NR_120686.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site at an internal exon, resulting in a shorter transcript, compared to variant 1.
    Source sequence(s)
    AL353803
    Related
    ENST00000444125.4

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    129336923..129347477
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    141539091..141549647
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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