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Eef1akmt3 EEF1A lysine methyltransferase 3 [ Mus musculus (house mouse) ]

Gene ID: 100504608, updated on 11-Apr-2024

Summary

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Official Symbol
Eef1akmt3provided by MGI
Official Full Name
EEF1A lysine methyltransferase 3provided by MGI
Primary source
MGI:MGI:3645330
See related
Ensembl:ENSMUSG00000080115 AllianceGenome:MGI:3645330
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam119b; Gm16109; EG546486; Mettl21b
Summary
Enables protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine methylation. Predicted to be located in centrosome; chromosome; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Orthologous to human EEF1AKMT3 (EEF1A lysine methyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 2.4), kidney adult (RPKM 2.3) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 D3; 10 74.5 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (126868654..126877883, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127032806..127042014, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene advillin Neighboring gene Ts translation elongation factor, mitochondrial Neighboring gene methyltransferase 1, tRNA methylguanosine Neighboring gene cytochrome P450, family 27, subfamily b, polypeptide 1 Neighboring gene membrane associated ring-CH-type finger 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The novel lysine specific methyltransferase METTL21B affects mRNA translation through inducible and dynamic methylation of Lys-165 in human eukaryotic elongation factor 1 alpha (eEF1A). Malecki J, et al. Nucleic Acids Res, 2017 May 5. PMID 28108655, Free PMC Article
  2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
  
enables methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-lysine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-lysine N-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein-lysine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-lysine methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-lysine methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-lysine methylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
EEF1A lysine methyltransferase 3
Names
Methyltransferase-like protein 21B
Protein-lysine methyltransferase METTL21B
family with sequence similarity 119, member B
methyltransferase like 21B
NP_001191965.1
XP_017169241.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205036.1 → NP_001191965.1  EEF1A lysine methyltransferase 3

    See identical proteins and their annotated locations for NP_001191965.1

    Status: VALIDATED

    Source sequence(s)
    AC134329
    Consensus CDS
    CCDS56752.1
    UniProtKB/Swiss-Prot
    D3YWP0
    Related
    ENSMUSP00000111939.3, ENSMUST00000116231.4
    Conserved Domains (1) summary
    cl17173
    Location:37 → 195
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    126868654..126877883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313752.3 → XP_017169241.1  EEF1A lysine methyltransferase 3 isoform X1

    Conserved Domains (1) summary
    cl17173
    Location:15 → 150
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3YWP0.1 GenPept UniProtKB/Swiss-Prot:D3YWP0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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