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Dcdc2b doublecortin domain containing 2b [ Mus musculus (house mouse) ]

Gene ID: 100504491, updated on 8-Mar-2024

Summary

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Official Symbol
Dcdc2bprovided by MGI
Official Full Name
doublecortin domain containing 2bprovided by MGI
Primary source
MGI:MGI:2686212
See related
Ensembl:ENSMUSG00000078552 AllianceGenome:MGI:2686212
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1366; Gm12964
Summary
This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in testis adult (RPKM 6.3), lung adult (RPKM 4.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dcdc2b in Genome Data Viewer
Location:
4 D2.2; 4 63.26 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (129501723..129508270, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (129607930..129614483, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 167, member B Neighboring gene STARR-positive B cell enhancer ABC_E11717 Neighboring gene eukaryotic translation initiation factor 3, subunit I Neighboring gene transmembrane protein 234 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:129287304-129287568 Neighboring gene STARR-positive B cell enhancer ABC_E10261 Neighboring gene IQ motif containing C Neighboring gene coiled coil domain containing 28B Neighboring gene STARR-seq mESC enhancer starr_11504 Neighboring gene predicted gene, 34305

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Common and divergent roles for members of the mouse DCX superfamily. Coquelle FM, et al. Cell Cycle, 2006 May. PMID 16628014
  2. The doublecortin gene family and disorders of neuronal structure. Dijkmans TF, et al. Cent Nerv Syst Agents Med Chem, 2010 Mar. PMID 20236041
  3. The evolving doublecortin (DCX) superfamily. Reiner O, et al. BMC Genomics, 2006 Jul 26. PMID 16869982, Free PMC Article
  4. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
doublecortin domain-containing protein 2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195730.2 → NP_001182659.1  doublecortin domain-containing protein 2B

    Status: VALIDATED

    Source sequence(s)
    AL671759
    Consensus CDS
    CCDS57299.1
    UniProtKB/TrEMBL
    F7BCK0, J3KML0
    Related
    ENSMUSP00000135913.2, ENSMUST00000179209.8
    Conserved Domains (2) summary
    cd01617
    Location:4 → 82
    DCX; Ubiquitin-like domain of DCX
    cl00155
    Location:91 → 177
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    129501723..129508270 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502634.5 → XP_006502697.1  doublecortin domain-containing protein 2B isoform X4

    Conserved Domains (1) summary
    cl28922
    Location:4 → 82
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  2. XM_006502633.5 → XP_006502696.1  doublecortin domain-containing protein 2B isoform X3

    UniProtKB/TrEMBL
    F7BCK0
    Conserved Domains (1) summary
    cl28922
    Location:4 → 82
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  3. XM_006502631.5 → XP_006502694.1  doublecortin domain-containing protein 2B isoform X1

    UniProtKB/TrEMBL
    F7BCK0
    Related
    ENSMUSP00000101653.3, ENSMUST00000106037.3
    Conserved Domains (1) summary
    cl28922
    Location:123 → 201
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  4. XM_006502632.5 → XP_006502695.1  doublecortin domain-containing protein 2B isoform X2

    UniProtKB/TrEMBL
    F7BCK0
    Conserved Domains (1) summary
    cl28922
    Location:123 → 201
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  5. XM_030253068.2 → XP_030108928.1  doublecortin domain-containing protein 2B isoform X5

    Conserved Domains (1) summary
    cl28922
    Location:1 → 39
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  6. XM_006502636.5 → XP_006502699.1  doublecortin domain-containing protein 2B isoform X6

    Conserved Domains (1) summary
    cl28922
    Location:4 → 82
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  7. XM_036163556.1 → XP_036019449.1  doublecortin domain-containing protein 2B isoform X6

    Conserved Domains (1) summary
    cl28922
    Location:4 → 82
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
Nucleotide Protein Strain
Heading Accession and Version

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