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Smim27 small integral membrane protein 27 [ Mus musculus (house mouse) ]

Gene ID: 100504309, updated on 8-Mar-2024

Summary

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Official Symbol
Smim27provided by MGI
Official Full Name
small integral membrane protein 27provided by MGI
Primary source
MGI:MGI:1913684
See related
Ensembl:ENSMUSG00000028407 AllianceGenome:MGI:1913684
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Toporsos; 2010003O02Rik
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human SMIM27 (small integral membrane protein 27). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 44.5), ovary adult (RPKM 42.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 20.24 cM; 4 A5
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (40269579..40270228)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (40269579..40270228)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene aconitase 1 Neighboring gene STARR-seq mESC enhancer starr_09982 Neighboring gene RNA sensor RIG-I Neighboring gene STARR-seq mESC enhancer starr_09983 Neighboring gene STARR-positive B cell enhancer ABC_E6161 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:40216827-40216936 Neighboring gene topoisomerase I binding, arginine/serine-rich Neighboring gene STARR-seq mESC enhancer starr_09984 Neighboring gene NADH:ubiquinone oxidoreductase subunit B6 Neighboring gene RIKEN cDNA 4930509K18 gene Neighboring gene STARR-seq mESC enhancer starr_09985

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Vertebrate Genome Annotation browser 10 years on. Harrow JL, et al. Nucleic Acids Res, 2014 Jan. PMID 24316575, Free PMC Article
  2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
small integral membrane protein 27
Names
TOPORS antisense RNA 1
Topors opposite strand transcript
topoisomerase I binding, arginine/serine-rich, opposite strand

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001349093.1 → NP_001336022.1  small integral membrane protein 27

    Status: VALIDATED

    Source sequence(s)
    AA190030, AL831793
    Consensus CDS
    CCDS89727.1
    UniProtKB/Swiss-Prot
    A0A140LHV9
    Related
    ENSMUSP00000146567.2, ENSMUST00000129758.3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    40269579..40270228
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_045265.1: Suppressed sequence

    Description
    NR_045265.1: This RefSeq was removed because it is now thought that this gene does encode a protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A140LHV9.1 GenPept UniProtKB/Swiss-Prot:A0A140LHV9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.