Trp53cor1 tumor protein p53 pathway corepressor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trp53cor1provided by MGI
Official Full Name: tumor protein p53 pathway corepressor 1provided by MGI
Primary source: MGI:MGI:3801771
See related: Ensembl:ENSMUSG00000085912 AllianceGenome:MGI:3801771
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm16197; linc-p21; lincRNA-p21
Summary: Acts upstream of or within negative regulation of gene expression. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 17 A3.3; 17 15.04 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (29276448..29298100, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (29057474..29079126, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

p53-Dependent LincRNA-p21 Protects Against Proliferation and Anti-apoptosis of Vascular Smooth Muscle Cells in Atherosclerosis by Upregulating SIRT7 via MicroRNA-17-5p.
Title: p53-Dependent LincRNA-p21 Protects Against Proliferation and Anti-apoptosis of Vascular Smooth Muscle Cells in Atherosclerosis by Upregulating SIRT7 via MicroRNA-17-5p.
LincRNA-p21 exon 1 expression correlates with Cdkn1a expression in vivo.
Title: LincRNA-p21 exon 1 expression correlates with Cdkn1a expression in vivo.
Exosomal lncRNA-p21 derived from mesenchymal stem cells protects epithelial cells during LPS-induced acute lung injury by sponging miR-181.
Title: Exosomal lncRNA-p21 derived from mesenchymal stem cells protects epithelial cells during LPS-induced acute lung injury by sponging miR-181.
Overexpression of lincRNA p21 promotes FOS expression by binding to miR-221, thereby, inhibiting hippocampal neuron apoptosis in diabetic mice
Title: Long intergenic noncoding RNA p21 suppresses the apoptosis of hippocampus neurons in streptozotocin-diabetic mice by sponging microRNA-221 through upregulation of FOS.
lincRNA-p21 significantly up-regulated in mouse breast cancer cell line 4T1 educated macrophages. LincRNA-p21 knockdown facilitated macrophage polarization into pro-inflammatory M1 in tumor microenvironment, which might be caused by Mdm2 eliciting proteasome-dependent degradation to p53 and activated NF-kappaB and Stat3 pathway.
Title: LincRNA-p21 knockdown reversed tumor-associated macrophages function by promoting MDM2 to antagonize* p53 activation and alleviate breast cancer development.
LincRNA-p21 promotes MSC migration and survival capacity through HIF-1a/CXCR4 and CXCR7 pathway under hypoxic preconditioning in vitro.
Title: LincRNA-p21 promotes mesenchymal stem cell migration capacity and survival through hypoxic preconditioning.
our present results extend the knowledge of lincRNA-p21 and deepen the understanding of the cross talk between lncRNA and profibrogenic TGF-beta signaling cascades in hepatocyte during liver fibrosis.
Title: TGF-β-induced hepatocyte lincRNA-p21 contributes to liver fibrosis in mice.
MIF protected MSCs from hypoxia/SDinduced apoptosis by interacting with lincRNAp21, leading to activation of the downstream Wnt/betacatenin signaling pathway and decreased oxidative stress. Thus, treatment with MIF may have important therapeutic implications in improving MSC survival and therapeutic efficiency.
Title: Role of lincRNA‑p21 in the protective effect of macrophage inhibition factor against hypoxia/serum deprivation‑induced apoptosis in mesenchymal stem cells.
It has been observed that even in tissues with no detectable Linc-p21 transcript, deletion of the locus significantly affects local gene expression, including of the cell cycle regulator Cdkn1a.
Title: In Vivo Characterization of Linc-p21 Reveals Functional cis-Regulatory DNA Elements.
The p53-induced lincRNA-p21 prevents cell reprogramming by sustaining H3K9me3 and/or CpG methylation at pluripotency gene promoters.
Title: The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Gene trapped (5) 1 citation

General gene information

Go to the top of the page Help

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.