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Efcab8 EF-hand calcium binding domain 8 [ Mus musculus (house mouse) ]

Gene ID: 100504221, updated on 8-Mar-2024

Summary

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Official Symbol
Efcab8provided by MGI
Official Full Name
EF-hand calcium binding domain 8provided by MGI
Primary source
MGI:MGI:3644206
See related
Ensembl:ENSMUSG00000044083 AllianceGenome:MGI:3644206
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm38434; EG329541; A630008I04
Summary
Predicted to enable calcium ion binding activity. Orthologous to human EFCAB8 (EF-hand calcium binding domain 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 6.1) See more
Orthologs
human all
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Genomic context

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Location:
2; 2 H1
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (153615231..153686672)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (153773311..153844752)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene DNA methyltransferase 3B Neighboring gene DNA methyltransferase 3C Neighboring gene sorting nexin 2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3413 Neighboring gene microtubule-associated protein, RP/EB family, member 1 Neighboring gene translocase of outer mitochondrial membrane 20 homolog pseudogene Neighboring gene Sad1 and UNC84 domain containing 5 Neighboring gene BPI fold containing family B, member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
  2. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC178411

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
eF-hand calcium-binding domain-containing protein 8
Names
EF-hand calcium-binding domain-containing protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370916.1 → NP_001357845.1  eF-hand calcium-binding domain-containing protein 8

    Status: VALIDATED

    Source sequence(s)
    AL833803
    Consensus CDS
    CCDS89569.1
    UniProtKB/TrEMBL
    H3BL58
    Related
    ENSMUSP00000135661.3, ENSMUST00000126656.4
    Conserved Domains (4) summary
    COG2319
    Location:190 → 511
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:432 → 470
    7WD40; WD40 repeat [structural motif]
    pfam13833
    Location:126 → 175
    EF-hand_8; EF-hand domain pair
    cl29593
    Location:381 → 673
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    153615231..153686672
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246361.1 → XP_030102221.1  eF-hand calcium-binding domain-containing protein 8 isoform X10

    Conserved Domains (4) summary
    COG2319
    Location:190 → 511
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:385 → 428
    7WD40; WD40 repeat [structural motif]
    pfam13833
    Location:126 → 175
    EF-hand_8; EF-hand domain pair
    cl29593
    Location:381 → 673
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_030246358.2 → XP_030102218.1  eF-hand calcium-binding domain-containing protein 8 isoform X9

    Conserved Domains (4) summary
    COG2319
    Location:190 → 511
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:385 → 428
    7WD40; WD40 repeat [structural motif]
    pfam13833
    Location:126 → 175
    EF-hand_8; EF-hand domain pair
    cl29593
    Location:381 → 673
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_030246363.2 → XP_030102223.1  eF-hand calcium-binding domain-containing protein 8 isoform X11

    Conserved Domains (4) summary
    COG2319
    Location:190 → 511
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:385 → 428
    7WD40; WD40 repeat [structural motif]
    pfam13833
    Location:126 → 175
    EF-hand_8; EF-hand domain pair
    cl29593
    Location:381 → 647
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_030246332.2 → XP_030102192.1  eF-hand calcium-binding domain-containing protein 8 isoform X2

    Conserved Domains (4) summary
    COG2319
    Location:190 → 511
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:432 → 470
    7WD40; WD40 repeat [structural motif]
    pfam13833
    Location:126 → 175
    EF-hand_8; EF-hand domain pair
    cl29593
    Location:381 → 673
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  5. XM_030246328.2 → XP_030102188.1  eF-hand calcium-binding domain-containing protein 8 isoform X1

    UniProtKB/TrEMBL
    H3BL58
    Conserved Domains (4) summary
    COG2319
    Location:190 → 511
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:432 → 470
    7WD40; WD40 repeat [structural motif]
    pfam13833
    Location:126 → 175
    EF-hand_8; EF-hand domain pair
    cl29593
    Location:381 → 673
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  6. XM_030246333.2 → XP_030102193.1  eF-hand calcium-binding domain-containing protein 8 isoform X3

    Conserved Domains (4) summary
    COG2319
    Location:828 → 995
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:432 → 470
    7WD40; WD40 repeat [structural motif]
    pfam13833
    Location:126 → 175
    EF-hand_8; EF-hand domain pair
    cl29593
    Location:381 → 609
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  7. XM_030246331.2 → XP_030102191.1  eF-hand calcium-binding domain-containing protein 8 isoform X1

    UniProtKB/TrEMBL
    H3BL58
    Conserved Domains (4) summary
    COG2319
    Location:190 → 511
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:432 → 470
    7WD40; WD40 repeat [structural motif]
    pfam13833
    Location:126 → 175
    EF-hand_8; EF-hand domain pair
    cl29593
    Location:381 → 673
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  8. XM_030246347.2 → XP_030102207.1  eF-hand calcium-binding domain-containing protein 8 isoform X5

    Conserved Domains (4) summary
    COG2319
    Location:752 → 919
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:263 → 301
    7WD40; WD40 repeat [structural motif]
    pfam13833
    Location:126 → 175
    EF-hand_8; EF-hand domain pair
    cl29593
    Location:381 → 625
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  9. XM_030246334.2 → XP_030102194.1  eF-hand calcium-binding domain-containing protein 8 isoform X4

    Conserved Domains (4) summary
    COG2319
    Location:131 → 452
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:373 → 411
    7WD40; WD40 repeat [structural motif]
    pfam13833
    Location:67 → 116
    EF-hand_8; EF-hand domain pair
    cl29593
    Location:322 → 614
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  10. XM_030246335.2 → XP_030102195.1  eF-hand calcium-binding domain-containing protein 8 isoform X4

    Conserved Domains (4) summary
    COG2319
    Location:131 → 452
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:373 → 411
    7WD40; WD40 repeat [structural motif]
    pfam13833
    Location:67 → 116
    EF-hand_8; EF-hand domain pair
    cl29593
    Location:322 → 614
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  11. XM_030246340.2 → XP_030102200.1  eF-hand calcium-binding domain-containing protein 8 isoform X4

    Conserved Domains (4) summary
    COG2319
    Location:131 → 452
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:373 → 411
    7WD40; WD40 repeat [structural motif]
    pfam13833
    Location:67 → 116
    EF-hand_8; EF-hand domain pair
    cl29593
    Location:322 → 614
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  12. XM_030246342.2 → XP_030102202.1  eF-hand calcium-binding domain-containing protein 8 isoform X4

    Conserved Domains (4) summary
    COG2319
    Location:131 → 452
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:373 → 411
    7WD40; WD40 repeat [structural motif]
    pfam13833
    Location:67 → 116
    EF-hand_8; EF-hand domain pair
    cl29593
    Location:322 → 614
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  13. XM_030246344.2 → XP_030102204.1  eF-hand calcium-binding domain-containing protein 8 isoform X4

    Conserved Domains (4) summary
    COG2319
    Location:131 → 452
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:373 → 411
    7WD40; WD40 repeat [structural motif]
    pfam13833
    Location:67 → 116
    EF-hand_8; EF-hand domain pair
    cl29593
    Location:322 → 614
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  14. XM_030246343.1 → XP_030102203.1  eF-hand calcium-binding domain-containing protein 8 isoform X4

    Conserved Domains (4) summary
    COG2319
    Location:131 → 452
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:373 → 411
    7WD40; WD40 repeat [structural motif]
    pfam13833
    Location:67 → 116
    EF-hand_8; EF-hand domain pair
    cl29593
    Location:322 → 614
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  15. XM_030246348.2 → XP_030102208.1  eF-hand calcium-binding domain-containing protein 8 isoform X6

    Conserved Domains (3) summary
    COG2319
    Location:29 → 350
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:271 → 309
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:220 → 512
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  16. XM_036157054.1 → XP_036012947.1  eF-hand calcium-binding domain-containing protein 8 isoform X7

    Conserved Domains (4) summary
    COG2319
    Location:30 → 330
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:251 → 289
    7WD40; WD40 repeat [structural motif]
    cd21577
    Location:1051 → 1109
    KLF3_N; N-terminal domain of Kruppel-like factor 3
    cl29593
    Location:200 → 492
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  17. XM_006500526.3 → XP_006500589.1  eF-hand calcium-binding domain-containing protein 8 isoform X8

    Conserved Domains (2) summary
    COG2319
    Location:66 → 228
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:103 → 138
    7WD40; WD40 repeat [structural motif]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177849.3: Suppressed sequence

    Description
    NM_177849.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

  2. NR_036629.1: Suppressed sequence

    Description
    NR_036629.1: This RefSeq was removed because it is now thought that this gene does encode a protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C9R9.1 GenPept UniProtKB/Swiss-Prot:Q8C9R9

Gene LinkOut

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Research Materials
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