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Nuggc nuclear GTPase, germinal center associated [ Mus musculus (house mouse) ]

Gene ID: 100503545, updated on 8-Mar-2024

Summary

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Official Symbol
Nuggcprovided by MGI
Official Full Name
nuclear GTPase, germinal center associatedprovided by MGI
Primary source
MGI:MGI:2685446
See related
Ensembl:ENSMUSG00000061356 AllianceGenome:MGI:2685446
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm600; SLIP-GC
Summary
Predicted to enable GTPase activity. Acts upstream of or within cellular response to DNA damage stimulus and somatic hypermutation of immunoglobulin genes. Located in nucleus. Orthologous to human NUGGC (nuclear GTPase, germinal center associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 1.5), placenta adult (RPKM 0.4) and 2 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 D1; 14 34.34 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (65830901..65885893)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (65593499..65648444)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9530047P18 gene Neighboring gene elongator acetyltransferase complex subunit 3 Neighboring gene STARR-seq mESC enhancer starr_36974 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:66211806-66212040 Neighboring gene STARR-seq mESC enhancer starr_36975 Neighboring gene STARR-seq mESC enhancer starr_36976 Neighboring gene STARR-seq mESC enhancer starr_36977 Neighboring gene predicted gene, 30245 Neighboring gene predicted gene, 53863 Neighboring gene scavenger receptor class A, member 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Altered pattern of immunoglobulin hypermutation in mice deficient in Slip-GC protein. Richter K, et al. J Biol Chem, 2012 Sep 14. PMID 22833677, Free PMC Article
  2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SLIP-GC protects replicating DNA from AID-mediated deamination of cytosines in both strands.
    Title: Altered pattern of immunoglobulin hypermutation in mice deficient in Slip-GC protein.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of nuclear cell cycle DNA replication ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within somatic hypermutation of immunoglobulin genes IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
nuclear GTPase SLIP-GC
Names
speckled-like pattern in the germinal center

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195674.2 → NP_001182603.2  nuclear GTPase SLIP-GC

    Status: VALIDATED

    Source sequence(s)
    AC122274
    Consensus CDS
    CCDS56966.1
    UniProtKB/TrEMBL
    D3YY21
    Related
    ENSMUSP00000078434.7, ENSMUST00000079469.7
    Conserved Domains (1) summary
    cl21455
    Location:300 → 466
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    65830901..65885893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518302.2 → XP_006518365.2  nuclear GTPase SLIP-GC isoform X1

    Conserved Domains (1) summary
    cl38936
    Location:128 → 197
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. XM_036158327.1 → XP_036014220.1  nuclear GTPase SLIP-GC isoform X3

    Conserved Domains (1) summary
    cl38936
    Location:128 → 197
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. XM_006518301.3 → XP_006518364.1  nuclear GTPase SLIP-GC isoform X2

    See identical proteins and their annotated locations for XP_006518364.1

    UniProtKB/Swiss-Prot
    D3YWJ0
    Conserved Domains (2) summary
    TIGR03597
    Location:80 → 123
    GTPase_YqeH; ribosome biogenesis GTPase YqeH
    cl38936
    Location:103 → 172
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. XM_006518303.3 → XP_006518366.1  nuclear GTPase SLIP-GC isoform X2

    See identical proteins and their annotated locations for XP_006518366.1

    UniProtKB/Swiss-Prot
    D3YWJ0
    Related
    ENSMUSP00000118402.2, ENSMUST00000150897.8
    Conserved Domains (2) summary
    TIGR03597
    Location:80 → 123
    GTPase_YqeH; ribosome biogenesis GTPase YqeH
    cl38936
    Location:103 → 172
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3YWJ0.1 GenPept UniProtKB/Swiss-Prot:D3YWJ0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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