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Cimap3 ciliary microtubule associated protein 3 [ Mus musculus (house mouse) ]

Gene ID: 100503311, updated on 8-Mar-2024

Summary

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Official Symbol
Cimap3provided by MGI
Official Full Name
ciliary microtubule associated protein 3provided by MGI
Primary source
MGI:MGI:1923670
See related
Ensembl:ENSMUSG00000010136 AllianceGenome:MGI:1923670
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pifo; 1700027A23Rik
Summary
Enables cytoskeletal protein binding activity and enzyme binding activity. Involved in regulation of cell projection organization. Acts upstream of or within with a positive effect on cilium organization. Acts upstream of or within embryonic heart tube left/right pattern formation. Located in ciliary basal body; nucleus; and trans-Golgi network. Is expressed in several structures, including brain ventricle and choroid plexus; embryo ectoderm; lung mesenchyme; node; and testis. Orthologous to human PIFO (primary cilia formation). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 31.5), lung adult (RPKM 2.0) and 1 other tissue See more
Orthologs
human all
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Genomic context

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Location:
3 F2.2; 3 46.47 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (105904273..105921962, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (105996957..106014646, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene WD repeat domain 77 Neighboring gene oviductal glycoprotein 1 Neighboring gene STARR-positive B cell enhancer ABC_E6099 Neighboring gene STARR-seq mESC enhancer starr_08642 Neighboring gene predicted gene 42722 Neighboring gene chitinase-like 5 Neighboring gene predicted gene 4540

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Morphological and molecular changes associated with Pitchfork during mouse palate development. Jin C, et al. Cell Tissue Res, 2014 Nov. PMID 25080064
  2. The correlative hypotheses between Pitchfork and Kif3a in palate development. Li S, et al. Med Hypotheses, 2019 May. PMID 31010494
  3. Islet vascularization is regulated by primary endothelial cilia via VEGF-A-dependent signaling. Xiong Y, et al. Elife, 2020 Nov 17. PMID 33200981, Free PMC Article
  4. Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation. Jung B, et al. PLoS One, 2016. PMID 26901434, Free PMC Article
  5. Pitchfork regulates primary cilia disassembly and left-right asymmetry. Kinzel D, et al. Dev Cell, 2010 Jul 20. PMID 20643351, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. there may be a potential correlation between Pitchfork and Kif3a that could regulate primary cilia disassembly during palate development
    Title: The correlative hypotheses between Pitchfork and Kif3a in palate development.
  2. Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation.
    Title: Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation.
  3. The proper expression levels of Pitchfork might play a pivotal role in normal secondary palate morphogenesis.
    Title: Morphological and molecular changes associated with Pitchfork during mouse palate development.
  4. Pitchfork (Pifo) associates with ciliary targeting complexes and accumulates at the basal body during cilia disassembly. Haploinsufficiency causes a unique node cilia duplication phenotype, left-right asymmetry defects, and heart failure.
    Title: Pitchfork regulates primary cilia disassembly and left-right asymmetry.
  5. 1700027A23Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
    Title: Tissue expression patterns identify mouse cilia genes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Homology

Clone Names

  • MGC58817

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables beta-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables cytoskeletal protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables gamma-tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables gamma-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables kinesin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables kinesin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within_positive_effect cilium organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic heart tube left/right pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell projection organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell projection organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ciliary microtubule-associated protein 3
Names
pitchfork
primary cilia formation
protein pitchfork

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001200028.1 → NP_001186957.1  ciliary microtubule-associated protein 3 isoform a

    See identical proteins and their annotated locations for NP_001186957.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AW492850, HM237138
    Consensus CDS
    CCDS51038.1
    UniProtKB/Swiss-Prot
    Q9D9W1
    Related
    ENSMUSP00000010280.5, ENSMUST00000010280.11

  2. NM_029604.3 → NP_083880.2  ciliary microtubule-associated protein 3 isoform b

    See identical proteins and their annotated locations for NP_083880.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AK006407, AW492850, AW519725
    Consensus CDS
    CCDS51037.1
    UniProtKB/Swiss-Prot
    D9J0A0, D9J0A1, Q810M7, Q9D9W1
    Related
    ENSMUSP00000069454.7, ENSMUST00000066319.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    105904273..105921962 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D9W1.1 GenPept UniProtKB/Swiss-Prot:Q9D9W1

Gene LinkOut

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