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Kcnmb3 potassium large conductance calcium-activated channel, subfamily M, beta member 3 [ Mus musculus (house mouse) ]

Gene ID: 100502876, updated on 8-Mar-2024

Summary

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Official Symbol
Kcnmb3provided by MGI
Official Full Name
potassium large conductance calcium-activated channel, subfamily M, beta member 3provided by MGI
Primary source
MGI:MGI:3612244
See related
Ensembl:ENSMUSG00000091091 AllianceGenome:MGI:3612244
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm5707; EG435726
Summary
Predicted to enable calcium-activated potassium channel activity and potassium channel regulator activity. Predicted to be involved in detection of calcium ion; neuronal action potential; and potassium ion transport. Predicted to be integral component of plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Orthologous to human KCNMB3 (potassium calcium-activated channel subfamily M regulatory beta subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
3 A3; 3 15.73 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (32518995..32557045, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (32465146..32502896, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930429B21 gene Neighboring gene zinc finger matrin type 3 Neighboring gene STARR-seq mESC enhancer starr_07335 Neighboring gene STARR-seq mESC enhancer starr_07336 Neighboring gene STARR-positive B cell enhancer ABC_E7906 Neighboring gene predicted gene, 54172 Neighboring gene phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Neighboring gene STARR-positive B cell enhancer ABC_E6047 Neighboring gene STARR-seq mESC enhancer starr_07337 Neighboring gene STARR-positive B cell enhancer ABC_E6048 Neighboring gene STARR-seq mESC enhancer starr_07340 Neighboring gene STARR-positive B cell enhancer ABC_E2662 Neighboring gene zinc finger protein 639 Neighboring gene mitofusin 1 Neighboring gene STARR-seq mESC enhancer starr_07342 Neighboring gene guanine nucleotide binding protein (G protein), beta 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. BK channels in microglia are required for morphine-induced hyperalgesia. Hayashi Y, et al. Nat Commun, 2016 May 31. PMID 27241733, Free PMC Article
  2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium-activated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-activated potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in action potential ISO
Inferred from Sequence Orthology
more info
  
involved_in detection of calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in detection of calcium ion ISO
Inferred from Sequence Orthology
more info
  
involved_in neuronal action potential ISO
Inferred from Sequence Orthology
more info
  
involved_in potassium ion transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
calcium-activated potassium channel subunit beta-3
Names
potassium large conductance calcium-activated channel, subfamily M, beta member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195074.1 → NP_001182003.1  calcium-activated potassium channel subunit beta-3

    Status: PROVISIONAL

    Source sequence(s)
    AC130281
    Consensus CDS
    CCDS57206.1
    UniProtKB/TrEMBL
    E9Q7U0
    Related
    ENSMUSP00000130177.2, ENSMUST00000164954.3
    Conserved Domains (1) summary
    pfam03185
    Location:41 → 232
    CaKB; Calcium-activated potassium channel, beta subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    32518995..32557045 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319414.3 → XP_017174903.1  calcium-activated potassium channel subunit beta-3 isoform X1

    Conserved Domains (1) summary
    pfam03185
    Location:62 → 253
    CaKB; Calcium-activated potassium channel, beta subunit

  2. XM_011249654.4 → XP_011247956.1  calcium-activated potassium channel subunit beta-3 isoform X2

    Conserved Domains (1) summary
    pfam03185
    Location:20 → 211
    CaKB; Calcium-activated potassium channel, beta subunit
Nucleotide Protein
Heading Accession and Version

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